Muri kamere, mannose ibaho muburyo bwubuntu mu mbuto zimwe na zimwe, nka cranberries, pome, amacunga, n'ibindi. Mu mubiri w'umuntu, mannose ikwirakwizwa mu ngingo zose n'amaraso, harimo uruhu, ingingo ndetse n'imitsi. Muri izo nyama, mannose igira uruhare muguhuza glycoproteine ??igenga imikorere ya sisitemu ya autoimmune. Ubushakashatsi bw’amavuriro bwerekanye ko mannose ishobora kuvura no gukumira indwara zanduza inkari, bityo bimwe mu bicuruzwa by’ubuzima bw’amahanga hamwe na mannose nkibice byingenzi bikoreshwa mu kubungabunga ubuzima bw’inkari.

Kuva kera bizwi ko ibibyimba bikenera glucose kuruta imyenda isanzwe. Tumor selile irashobora gufata inshuro zigera kuri 10 glucose nkingirabuzimafatizo zisanzwe kandi ikishingikiriza cyane kuri glycolysis kugirango imbaraga zikomeze gukura vuba. Nyamara, ikibyimba "isukari nkubuzima", imbere ya mannose, ariko ibintu bitandukanye byabaye. Muri 2018, ikinyamakuru Nature cyasohoye ubushakashatsi bwakozwe n’ubushakashatsi bwa Kanseri mu Bwongereza ko mannose ishobora kubuza ibibyimba. Abashakashatsi basanze ko mannose imaze kwinjira mu ngirabuzimafatizo, ikusanyiriza imbere mu ngirabuzimafatizo mu buryo bwa mannose 6-fosifate, ikabuza ingufu z’ikibyimba kubangamira metabolisme ya glucose, bityo bikabuza gukura kw ingirabuzimafatizo. Kugira ngo hemezwe uyu mwanzuro, abashakashatsi bakoze ubushakashatsi ku buryo bwerekana ikibyimba cy’imbeba, bongeraho mannose ku mazi yo kunywa y’izi mbeba "kanseri", banasuzuma ingaruka za mannose yo mu kanwa ku kuvura kanseri zitandukanye nka kanseri yandura na kanseri y'ibihaha ku mbeba. Ibisubizo byagaragaje ko gukoresha umunwa mannose ukoresheje amazi yo kunywa bidindiza neza gukura kwikibyimba ku mbeba. Nyuma yo kwemeza ingaruka zo kuvura mannose mu buryo bwerekana ikibyimba cy’imbeba, abashakashatsi batekereje gutanga mannose ku mbeba hiyongereyeho imiti ya chimiotherapie yo kuvura imiti, kandi batunguwe no kubona ko mannose yongereye imbaraga zo kuvura imiti ya chimiotherapie, bitagabanya gusa umubyimba w’ibibyimba mu mbeba, ahubwo binongerera igihe cy’imbeba "kanseri". Muri uyu mwaka, itsinda ry’ubushakashatsi muri kaminuza ya Fudan ryabonye uburyo bushya bwa mannose irwanya kanseri - igenga molekile igenzura ubudahangarwa PD-L1. Ikizamini cyo gukingira ikibyimba ni iki? Turabizi ko mugihe imibiri yamahanga nka bagiteri na virusi zo hanze zateye cyangwa selile zo mumubiri zipfa cyangwa zikaba kanseri, imikorere yubudahangarwa bwumubiri wumuntu izakora, kandi sisitemu yumubiri izagira uruhare nyuma yo gukora kugirango ikureho "molekile zinyamahanga". Muri icyo gihe, kugira ngo twirinde gukora cyane sisitemu y’umubiri no "kwica mu buryo butarobanuye" ingirabuzimafatizo zisanzwe mu mubiri, hariho umubiri wa "molekile igenzura umubiri" mu mubiri. PD-L1 ni molekile ikomeye yo kugenzura umubiri mu mubiri, ishobora guhuza na molekile ya PD-1 hejuru y’uturemangingo tw’umubiri kandi ikohereza ikimenyetso cya "feri" mu ngirabuzimafatizo kugira ngo hirindwe iyicwa ry’uturemangingo dusanzwe dukingira umubiri (Ishusho 2). Nyamara, ubu buryo bwa feri mumubiri wacu bukoreshwa nuburiganya bwibibyimba, kandi T selile yibibyimba microen ibidukikije ishinzwe kwica ibibyimba, kandi selile yibibyimba bizarekura ibimenyetso bya "feri" kuri selile T binyuze mumagambo menshi ya molekile ya PD-L1, bikabuza ibikorwa bya selile T, kugirango birinde kwica sisitemu yumubiri.

Molekile ya PD-L1 ni poroteyine ikungahaye kuri glycosylation. Itsinda ry’ubushakashatsi muri kaminuza ya Fudan ryasanze mannose ishobora kwangiza poroteyine ya PD-L1 igenga glycosylation ya molekile ya PD-L1, bityo bigatuma habaho kwangirika kwa molekile ya PD-L1. Noneho, mugihe molekile ya PD-L1 igaragara cyane mungirangingo yibibyimba yangijwe na mannose, selile yibibyimba ntishobora guhatira selile T "feri"? Abashakashatsi bemeje hypothesis: selile yibibyimba bivurwa na mannose byashobokaga kwicwa na selile T; Muburyo bwibibyimba byimbeba, mannose yo munwa irashobora guteza imbere gutera no kwica selile T ikibyimba kandi ikabuza ikura ryikibyimba, kandi guhuza imiti ya antibody ya mannose hamwe nubudahangarwa bw'umubiri birinda gutera no kwica selile T kubyimba, kandi bikongerera cyane ubuzima bwimbeba za "kanseri".

Nkuko twabivuze mbere, mannose iboneka mubisanzwe mu mbuto zimwe na zimwe, cyane cyane cranberries zifite mannose nyinshi (Ishusho 3). Abantu benshi bashobora kwibaza, kurya igikoma birashobora kwirinda cyangwa kuvura kanseri? Mubyukuri, ubunini bwa mannose bwahawe imbeba "kanseri" mubushakashatsi bubiri bwavuzwe haruguru bwari hejuru ya 20%, bivuze ko buri 100ml y'amazi yo kunywa arimo 20g ya mannose, ikaba yibanda cyane kandi ikabije. Kubwibyo, turya cranberries nizindi mbuto kugirango twongere gufata mannose, kurwego runaka, irashobora guteza imbere ubudahangarwa, ifasha ubuzima, ariko dushaka kugera ku ngaruka ziterwa na kanseri yonyine ntabwo iri kure bihagije.