1.1 Kuva muri selile gusana kugeza kugenzura ubwonko

Kubera ko Citicoline yashizwemo bwa mbere na Takeda Pharmaceutical yo mu Buyapani mu 1956, amateka yayo yo kuyikoresha ashobora gufatwa nkamateka yo kuzamura ubwenge:

• 1980:Gusa ikoreshwa nka selile membrane yo gusana nyuma yubwonko

• 2010:Byagaragaye ko bishobora kongera ubwonko bwamaraso (PET-CT yerekanye ubwiyongere bwa 23% bwamaraso yigihe gito)

• Mu 2024,NIH yo muri Amerika yashyize ku rutonde nk'ibintu by'ingenzi bigenga "guhuza imitsi"

1.2 Iterambere riturika ryisoko ryisi

Ukurikije amakuru ya Evaluate Pharma:

Igurishwa ku isi ryageze kuri miliyari 4.7 z'amadolari ya Amerika mu 2024 (CAGR 12.3%)

Imiti ikoreshwa mubitaro byintangarugero mubushinwa yiyongereyeho 400% mumyaka itatu

Ibimenyetso byaguwe kuri:

Indwara y'amaraso (amanota MMSE yazamutseho amanota 2.1)

Gukomeretsa ubwonko (igipimo cya GOS cyiyongereyeho amanota 1.5)

Igice cya kabiri: Umukara-agasanduku Kumenagura uburyo bwibikorwa

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2.1 Inzira eshatu zikorwa

Intego yibikorwa byerekana urwego: Phosphatidylcholine synthesis isana neuronal membrane ubunyangamugayo Icyiciro cya mbere: Acetylcholine preursors yongerera ubwonko bwa neurotransmitter Icyiciro cya IIA: Amabwiriza ya Nitric oxyde synthase atezimbere kwaguka mikorobe (diameter yiyongera 18%) Icyiciro IIB

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2.2 Ivuriro rya zahabu ryigihe

Ubushakashatsi bwakozwe mu 2024 n’ibitaro bya mbere bishamikiye kuri kaminuza ya Sun Yat-sen byerekana:

Gutera inshinge 1000mg mugihe cyamasaha 6 nyuma yubwonko bwubwonko burashobora gukiza agace ka penchema ischemic kugeza kuri 7.2cm3

Ariko, nta tandukanyirizo rishingiye ku mibare ryabayeho igihe ubuyobozi bwarenze amasaha 72 (p = 0.34).

Igice cya gatatu: Umuhengeri w'amakimbirane

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3.1 Gushidikanya kubyerekeye agaciro

Amabwiriza NICE yo mu Bwongereza: Bifatwa ko ibimenyetso bihari bidahagije kugira ngo bishyigikire ubwishingizi bw'indwara (igipimo cy’ibiciro ￡ 45,000 / QALY)

Lancet Neurology ** 2025 Meta-gusesengura: Nta tandukaniro rikomeye ritandukanye na placebo mu itsinda ryoroheje ryubwenge buke (p = 0.21)

3.2 Akajagari mu kuzamura ubucuruzi

Ikigo cy’igihugu gishinzwe ubuvuzi bwamenyeshejwe 2024:

Ibigo cumi na bibiri byakabije ibimenyetso (biteza imbere "imiti ivura" nka "reversing dementia")

Ibizamini kurubuga runaka rwa e-ubucuruzi byerekana ko ibikubiye muri 32% byateguwe mu kanwa biri munsi ya 70% byamafaranga yanditseho

Igice cya kane: Imipaka yiterambere ryikoranabuhanga

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4.1 Sisitemu nshya yo gutanga ibiyobyabwenge

Inzitizi yamaraso-ubwonko yinjira muri peptide yahinduwe liposomes (Patent yikipe ya kaminuza ya Peking, CN202410123456.7)

Microneedles isubiza-irekura (Ubushakashatsi bwinyamanswa muri kaminuza nkuru ya Seoul muri Koreya yepfo bwerekana ubwiyongere bwikubye gatatu bioavailability)

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4.2 Umuseke wimiti kugiti cye

Ubushakashatsi bwakozwe na Bgi bwerekanye ko:

Ingaruka yimiti yabaturage ba CDP-cholinesterase gene polymorphique (bangana na 31% byabaturage ba Aziya) yiyongereyeho 47%

Igice cya Gatanu Amakuru nyayo-y’abarwayi

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5.1 Imanza z'Abagenerwabikorwa

Inyandiko yavuye mu bitaro bya kaminuza i Hangzhou: Nyuma yo kuvurwa hamwe, ubushobozi bw’amaraso y’ubwonko bw’umurwayi w’imyaka 62 ufite ubwonko bw’ubwonko bwakuwe kuri 32% bugera kuri 89%

5.2 Kwiyitirira ishyaka ritemewe

"Gufata igice cy'umwaka ubudasiba, amafaranga ya buri kwezi angana na Yuan 300 yazanye gusa ikibazo cyo mu gifu" - inyandiko yabajijwe na Madamu Li, umurwayi ukomoka i Beijing