Citolineni nucleotide imwe igizwe na acide nucleic, cytosine, pyrophosifate na choline, ikoreshwa cyane mubuvuzi bwindwara zitandukanye zifata ubwonko, nk'indwara ya Alzheimer, sclerose nyinshi, sclerose ya amyotrophique. Ubushakashatsi bwerekanye kandi ko citicoline ishobora kongera ubwonko gufata dopamine na glutamate, bityo bikazamura imikorere yubwenge. Ciphocholine irashobora kandi kugabanya irekurwa rya acide yubusa kandi ikagarura ibikorwa bya mitochondrial ATPase na selile membrane Na + / K + ATPase, bityo bikagabanya ibikomere byubwonko. Nyamara, uburyo bwa pathophysiologique bwindwara zifata ubwonko buragoye kandi burimo kubura cholinergique, glutamate excitotoxicity, neuroinflammation, dysregulation immunité, kugabanuka kwa glucose metabolism, no gusenya inzitizi yubwonko bwamaraso.

CitolineIrashobora guhagarika ingirabuzimafatizo ikangurira S-adenosine-L-methionine, kongera ubunini bwa dendrite hamwe nubucucike bwimiterere yimiterere ya moteri ya neuron, kunoza plastike yimitsi ahantu hatangiritse, no guteza imbere imikorere myiza.

Citicoline irashobora kugabanya urwego rwa fosifate ya elegitoronike ya fosifate ikwirakwiza choline fosifate cytidylytransferase (CCT) kandi ikabuza ibikorwa bya fosifolipase y'ibanga A2 (PLA2) cyangwa ikabuza gukora PLA2 mukubuza TNF-a / IL-1b kugirango igabanye igihombo cya fosifoli. membrane.

Citicoline irashobora kandi kongera imvugo yibintu birwanya apoptotique nka Bcl-2 no kubuza glutamate kurekura cytotoxicity.

Ciphocholine iteza imbere gusana byihuse hejuru y’utugingo ngengabuzima twangiritse ndetse na mitochondrial membrane, igakomeza gukomera kw’imikorere n’imikorere y’ibinyabuzima, kandi igabanya irekurwa rya aside irike ku buntu, bityo bikagabanya metabolite y’ubumara ya ogisijeni kandi ikabyara umusaruro ukabije.

Citicoline irashobora kongera urugero rwa vasopressine na plasma adrenotropine, kandi igatera gusohora imisemburo ikura, thyrotropine na luteinizing hormone.

Hariho uburyo bwinshi bwo gutegura sodium ya citicoline, cyane cyane inzira eshatu.

Imwe muriyo ni fermentation ya mikorobe. Ubu buryo bufite ibibazo bimwe nkibicuruzwa bike hamwe numusaruro udahungabana.

Imwe muriyo ni synthesis ya chimique. Hano haribibazo bimwe murubu buryo, nkibicuruzwa biragoye gutandukanya imvange yo kugabanuka, ntibikwiriye gukoreshwa imiti, igipimo gito cyo guhindura reaction, ibicuruzwa byinshi, ibicuruzwa bihenze hamwe n’umwanda ukabije w’ibidukikije.

Hariho kandi uburyo bwo guhuza imisemburo ya enzymatique, nko gukoresha umusemburo winzoga byondo nibindi binyabuzima bikoresha biosynthesis. Utugingo ngengabuzima twenga inzoga twakoreshejwe muguhindura imisemburo. Inzira yari yoroshye, igipimo cyo guhindura cyari kinini kandi igiciro cyari gito. Igikorwa cyo gukora sodium ya citoline ikomatanyirijwe hamwe na synthesis enzymatique irashobora kugabanywamo ibice bibiri: inzira ya synthesis enzymatique hamwe nogukuramo no kweza.

Ufashe mu kanwa, winjizwa vuba, hydrolyzed mu mara n'umwijima kugeza choline na cytosine, byinjira mu maraso, bikarenga inzitizi y'amaraso n'ubwonko, hanyuma bikongera bikinjira muri citicoline muri sisitemu yo hagati yo hagati, aho 80% bya sintezike ya fosifolipide yibasirwa na citoline mu mubiri.

Byongeye kandi, citoline ihindurwamo acetyloline muri sisitemu yo hagati yo hagati hanyuma igahinduka okiside kuri betaine mu mpyiko n'umwijima. Amazi meza ya citicoline ni meza, bioavailable iri hejuru ya 90%, kandi munsi ya 1% ni yo isohoka muntebe nyuma yubuyobozi bwo munwa. Hano hari impinga 2 zo kwinjiza muri plasma, isaha 1 namasaha 24 nyuma yo gufatwa.

Muburyo bwimbeba, urugero rwa citoline ya radiolabel yiyongereye cyane mubwonko nyuma yamasaha 10 yatewe kandi ikwirakwizwa cyane mubintu byera kandi byera byubwonko. Ubushuhe bwinshi buguma kumasaha 48, kandi kurandura kwayo biratinda cyane, hamwe na bike bisohoka buri munsi binyuze muminkari, umwanda, no guhumeka. Kwinjira cyane kwa citoline birashobora guteza imbere gusana byihuse ibyangiritse byangiritse na mitochondriya, bikagumana ubusugire bwimikorere nimikorere yibinyabuzima, kandi bikabuza apoptose nurupfu.