Iri ni isubiramo riherutse, ryasohotse mu kinyamakuru kizwi cyane cyitwa Nutrients muri Gashyantare 2024, cyanditswe na Ligia J. Dominguez n'abandi bo muri kaminuza ya Palermo na kaminuza ya Enna mu Butaliyani. Basuzumye buri gihe isano iri hagati ya magnesium n'ibipimo byo gusaza mu mubiri w'umuntu, basanga iyi minerval isanzwe ishobora kugabanya umuvuduko wo gusaza, ibyo rwose biratangaje!

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Inama z'ingenzi:

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1. Magnesium nikintu cya kane cyinshi cyimyunyu ngugu mumubiri wumuntu kandi gifitanye isano rya bugufi nigikorwa cyimisemburo irenga 600, bigira ingaruka kumikorere itandukanye.

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2.Ibura rya magnesium rikunze kugaragara cyane mu bageze mu za bukuru, rifitanye isano nibintu byinshi nka gen, ibidukikije n'imibereho. Urwego rwa magnesium rudahagije mu mubiri rushobora kwihutisha gusaza.

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3. Ubushakashatsi bwerekanye ko magnesium ishobora kugira ingaruka 12 zingenzi zogusaza, harimo ihungabana rya genomique, kugabanuka kwa telomere, nimpinduka za epigenetike. Kwiyongera kwa magnesium biteganijwe ko bidindiza gusaza no kunoza ibyifuzo byubuzima.

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Dore incamake irambuye yingingo yumwimerere:

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Kubura Magnesium byihutisha ibintu 12 byo gusaza

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Guhungabana kwa genomic: Magnesium ituma ADN ikora kabiri kandi ikagira uruhare muburyo butandukanye bwo gusana ADN. Kubura Magnesium birashobora gutuma habaho kwangirika kwa ADN, kwiyongera kw'imiterere ihindagurika, no gusaza vuba.

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Kugabanuka kwa Telomere: Telomeres isubirwamo ikurikiranye kumpera ya chromosomes irinda genome kwangirika. Magnesium ituza iherezo.

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Impinduka za Epigenetike: Impinduka ya Epigenetike mu mvugo ya gene ibaho idahinduye urutonde rwa ADN. Magnesium igenga uburyo bwa epigenetike nka methylation ya ADN no guhindura histone.

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Intungamubiri za poroteyine homeostasis: intungamubiri za poroteyine no kwangirika mu ngirabuzimafatizo bigera ku ntera ishimishije, bita protein homeostasis. Magnesium igira uruhare mu kugenzura imikorere ya proteasome na lysosome, kandi kubura magnesium biganisha ku kwegeranya poroteyine zitabitswe neza.

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Guhungabanya imyumvire yimirire: Insuline / IGF-1 nizindi nzira zerekana inzira imirire ya selile kandi igenga metabolism. Magnesium ni cofactor ya reseptor ya insuline na kinase yo hepfo, kandi kubura magnesium bitera kurwanya insuline.

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Imikorere mibi ya Mitochondrial: Mitochondriya ni inganda zingirabuzimafatizo, kandi ADN n'iminyururu y'ubuhumekero birashobora kwangirika. Manyeziyumu ni iya kabiri muri cation nyinshi muri mitochondriya, igira uruhare muri synthesis ya ATP na antioxydeant, kandi kubura magnesium byongera kwangirika kwa mito.

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Ingirabuzimafatizo ya selile: selile senescent ihagarika kugabana, gusohora ibintu bitera umuriro, no kwangiza ibidukikije bya tissue. Magnesium irashobora kubuza ingirabuzimafatizo guhagarika poroteyine p53 na p21 no gutinza senescence.

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Kugabanuka kw'ingirabuzimafatizo: Ingirabuzimafatizo zifite inshingano zo kuvugurura no gusana, kandi umubare n'imikorere bigabanuka uko imyaka igenda ishira. Magnesium igira ingaruka ku gutandukanya ingirabuzimafatizo ya hematopoietic, kandi ibura rya magnesium rishobora kwihutisha igabanuka ry'uturemangingo.

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Impinduka mu itumanaho hagati: cytokine, imisemburo, nibindi bihuza guhanahana ibimenyetso. Gusaza byongera ururenda rwibintu bitera umuriro. Magnesium ibuza gucana kandi itezimbere itumanaho.

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Autophagy yangiritse: Autophagy ninzira yingenzi ingirabuzimafatizo zigabanya poroteyine zangiritse. Magnesium ikomeza imikorere ya autofagy muguhuza ibikorwa bya autofagy bijyanye na gen na kinase.

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Indwara yo mu mara: flora yo munda igira uruhare mu guhinduranya intungamubiri no kugenzura ubudahangarwa bw'umubiri, kandi ubusumbane bwa mikorobe bujyanye no gusaza. Magnesium igenga amara kandi igateza imbere ubuzima bwakiriye.

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Indurwe idakira: Gusaza biherekejwe no gutwika indwara zo mu rwego rwo hasi mu mubiri, ni ukuvuga "gusaza inflammatory". Kubura Magnesium bitera gukora cyane inzira yerekana ibimenyetso nka NF-κB kandi byongera igisubizo cyo gutwika.

Nk’uko umubare munini w’ubushakashatsi bw’ibyorezo bya epidemiologiya hamwe n’ibigeragezo byateganijwe byateganijwe, kongera ibiryo bya magnesium no gufata ibyokurya bya magnesium bishobora kugabanya indwara ziterwa n’imyaka idakira, kurwanya insuline, indwara zifata umutima, n’ibindi.

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Nubwo magnesium ifite umutekano muke, abantu bafite ikibazo cyo kubura impyiko bagomba kwitonda, kandi umubare munini wimiti yo mumanwa irashobora gutera impiswi. Abakuze bakuze bagomba gushyira imbere kubona magnesium ihagije mu mafunguro yabo, nk'imboga rwatsi rwatsi, ibinyampeke, imbuto, n'ibindi. Nibiba ngombwa, ukurikize inama za muganga zo kongeramo magnesium, kandi uhore ukurikirana amaraso ya magnesium.

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Ibimenyetso birambuye byubushakashatsi hamwe namakuru yubuvuzi:

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Ibimenyetso byubushakashatsi bwa magnesium na genomic stabilite ADN ni genetiki yubuzima, kandi ituze ryayo niyo shingiro ryimikorere isanzwe ya selile. Ubushakashatsi bwerekanye ko hari ioni ya magnesium iri hagati ya 50% byombi byibanze mu miterere ya ADN ya kabiri ya helix, igira uruhare mu guhagarika imiterere. Mu binyabuzima byintangarugero nka Escherichia coli numusemburo, ibidukikije bya magnesium bitera kwiyongera cyane mubipimo byo kwigana ADN. Ubushakashatsi bw’umuco wa fibroblast bwabantu bwemeje kandi ko magnesium nkeya ishobora gutera kwihuta kwa telomere no kugenzura imiterere ya ADN yangiza imiterere ya gene. Ubushakashatsi bw’inyamaswa bwerekanye ko sisitemu yo kwirinda antioxydeant yangiritse mu mwijima w’umwijima w’imbeba zabuze magnesium, kandi urwego rwa 8-hydroxy-deoxyguanosine, ikimenyetso cyangiza ADN ya okiside, rwiyongereye. Ubushakashatsi bwakozwe ku mbeba bwerekanye ko kunywa amazi akungahaye kuri magnesium byongereye uburebure bwa telomere kandi bikagabanya kwangirika kwa ADN. Ibisubizo byerekana ko magnesium ari ngombwa kugirango ibungabunge ituze.

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Mu bushakashatsi bw’abaturage, urugero rwa serumu cyangwa erythrocyte magnesium byahujwe nabi n’ibimenyetso bitandukanye byerekana ihungabana ry’imiterere ya genomic, nka micronucleus inshuro nyinshi, urugero rw’ibicuruzwa byangiza ADN 8-hydroxy-deoxyguanosine, n'uburebure bwa telomere. Ubushakashatsi bwibanze ku bantu bakuze bagera kuri 200 bafite ubuzima bwiza bwerekanye ko abafite umuvuduko ukabije w’amaraso atukura ya magnesium bafite uburebure bwa lymphocyte telomere ya peripheri y’amaraso, ugereranije, 11,5% ugereranije n’abafite urugero rwa magnesium nyinshi. Ubundi bushakashatsi bwakozwe ku bantu 1800 bageze mu za bukuru n’abasaza bafite hagati y’imyaka 45-74 bwakurikijwe mu myaka 5 bwerekanye ko gufata magnesium yimirire bifitanye isano ribi cyane n’urwego rwangirika rwa ADN muri lymphocytes y’amaraso ya periferique, kandi ko buri kwiyongera kwa magnesium gufata 100mg / ku munsi byagabanije urugero rw’ibyangiritse kuri ADN 5.5% nyuma y’imyaka 5. Ibi byerekana ko inyongera ya magnesium mu bantu ishobora no gufasha kubungabunga umutekano wa genomic.

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Icya kabiri, isano iri hagati yibikorwa bya magnesium na telomerase hamwe no gusaza kwa selile Telomeres nuburyo bwihariye kumpera ya chromosomes, igizwe na TTAGGG isubiramo hamwe na poroteyine za telomere zihuza, zirinda chromosomes kwangirika mugihe cyo kugabana selile. Ariko mu ngirabuzimafatizo z'umuntu, uburebure bwa telomere bugabanuka kugeza kuri 50 kugeza kuri 100 kuri buri gice, kandi iyo kugabanuka bigeze ku gaciro gakomeye, selile yinjira muri senescence. Telomerase ni ribonucleoprotease yongerera umurongo wa telomere, ariko mubisanzwe ntigaragazwa nabi cyangwa ntigaragare muri selile zikuze.

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Muri fibroblast ya imbeba (MEF), magnesium ntoya yagabanije ibikorwa bya telomerase hejuru ya 50% kandi yerekana ibimenyetso bya senescence ya selile, nko kongera ibikorwa bya galaktosidase no kwerekana-kugenzura imiterere ya selile inhibitor p16 na p21. Izi fenotipike zishaje zirashobora guhindurwa nyuma yo kuvurwa hamwe na magnesium cyangwa telomerase. Ibisubizo nkibi byagaragaye muri selile ya endothelia yumuntu na fibroblast. Ubushakashatsi bwakozwe na molekuline bwerekanye ko magnesium ishobora kugenzura uburebure bwa telomere bigira ingaruka ku mvugo no mu turere twa poroteyine zimwe na zimwe zikomeye mu kigo cya telomere, nka TRF1 na TRF2. Byongeye kandi, magnesium irashobora kandi gukora inzira zerekana ibimenyetso nka AKT na ERK, kandi ikabuza ingirabuzimafatizo za selile nka p53 na Rb, bityo bikadindiza gusaza kwa selile.

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Ubuvuzi bwa Clinical nabwo bushigikira isano iri hagati ya magnesium na senescence ya selile. Mu bageze mu za bukuru barenga 100 bafite ubuzima bwiza, urugero rwa serumu magnesium rwahujwe neza n’ikwirakwizwa rya lymphocyte T kandi rifitanye isano ribi na plasma p16. Ubundi bushakashatsi bwarimo abantu 250 bageze mu za bukuru mu baturage, basanga urugero rwa serumu ya magnesium ya sima yari ifitanye isano rya bugufi n’imihindagurikire y’ibipimo byerekana gusaza kwa physiologique nko kumva amajwi, gufata imbaraga, n’umuvuduko ukabije, byerekana ko imiterere ya magnesium ishobora kugira ingaruka ku gusaza muri rusange mu mubiri. Ubushakashatsi bwakozwe ku bantu barenga 2000 barengeje imyaka 70 bagereranije urugero rwa serumu magnesium itandukanye n’imyaka 10 yo guhitanwa n’urupfu maze basanga itsinda rifite urugero rwa magnesium ruri hasi cyane rifite ibyago by’urupfu inshuro 2,2 ugereranije n’itsinda rifite urwego rwo hejuru. Nubwo ubu bushakashatsi bwo kwitegereza budashobora kwerekana neza impamvu nimpamvu, bishyigikira isano ikomeye hagati ya magnesium no gusaza ukurikije abaturage.

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Uruhare rwa magnesium muri insuline yerekana inzira Insuline ni umusemburo wibanze wamaraso ya glucose homeostasis. Iyo insuline imaze guhuza reseptor yayo, itera kwifata-fosifora ya reseptor, kandi igakora urukurikirane rwa protein kinase yo hepfo nka PI3K na AKT, hanyuma ikagenga imvugo ya genes zijyanye na glucose metabolism. Ubushakashatsi bwinshi bwerekanye ko magnesium igira uruhare runini muri buri ntambwe ya insuline yerekana. 1. Muri selile islet beta, magnesium ikora complexe ya MgATP hamwe na ATP kugirango igire uruhare mubikorwa byose bya synthesis ya insuline, gutunganya no gusohora. Imbeba nimbeba beta selile, imiyoboro ya magnesium nkeya yagabanije glucose-iterwa na insuline kurenga 70%. 2. Muri 3T3-L1 adipocytes na L6 selile yimitsi ya skeletale, uburyo bwa magnesium nkeya bwagabanije glucose ya insuline iterwa na 40% kugeza 60%. 3. Ubushakashatsi bumwe bw’inyamaswa bwerekanye ko kuzuza indyo yuzuye ya magnesium byongera insuline irwanya umubyibuho ukabije n’imbeba ya diyabete yo mu bwoko bwa 2.

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Icyorezo cya Epidemiologiya nacyo gishyigikira isano ya hafi hagati ya magnesium na glucose metabolism. Ubushakashatsi bw’ubuzima bw’abaforomo bo muri Amerika, bwarimo abagore bagera ku 70.000 barengeje imyaka 45 bakurikiranye mu myaka irenga 20, bwerekanye ko abari muri quintile nyinshi y’ibiryo bya magnesium bafite indyo yuzuye bafite 27% byo kwandura diyabete yo mu bwoko bwa 2 kurusha abo muri quintile yo hasi. Isesengura ryakozwe na 25 ryakozwe na cohort ryitabiriwe n’abantu bagera kuri miliyoni imwe ryerekanye ko buri 100mg / ku munsi kwiyongera kwa magnesium y’imirire bifitanye isano no kugabanuka kwa 8% kugeza kuri 13% ibyago byo kurwara diyabete yo mu bwoko bwa 2. Ku bantu barwaye diyabete iriho, kugabanuka kwa serumu magnesium nabyo bifitanye isano rya bugufi niterambere ryindwara nibibazo. Ubushakashatsi bwakozwe ku barwayi barenga 300 barwaye diyabete yo mu bwoko bwa 2 bwerekanye ko urugero rwa serumu magnesium rwaragabanutse cyane ku bafite indwara z'umutima zifata umutima kurusha ababana na diyabete bonyine. Mu gusoza, umubare munini w’ubushakashatsi werekanye ko inyongera ya magnesium ishobora gutinza gusaza mu kunoza insuline.

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4. Kubura Magnesium no gukora nabi mitochondrial Mitochondria niho hantu h’ingenzi haterwa ingufu za selile metabolisme nubwoko bwa ogisijeni ikora (ROS). Mugihe cyo gusaza, imikorere ya transport ya mitochondrial electronique itwara igabanuka kandi umusaruro wa ROS ukiyongera, bigatera ihinduka rya mtDNA, membrane lipid peroxidation nibindi byangirika, bikagira uruziga rukabije kandi byihuta gusaza kwingirabuzimafatizo. Ubushakashatsi bwerekanye ko kimwe cya gatatu cya magnesium mu mubiri kibikwa muri mitochondria, kikaba ari ngombwa mu kubungabunga imiterere n'imikorere ya mito-iyambere. Mu mwijima wimbeba mitochondria, icyenda muri 13 subunits ya adenosine triphosphatase isaba magnesium nka cofactor. Imbeba myocardial mitochondria, magnesium nkeya irashobora kugabanya cyane ibikorwa byimisemburo yingenzi muri cycle ya tricarboxylic, nka isocitrate dehydrogenase na α-ketoglutarate dehydrogenase. Mu mwijima w'imbeba mitochondria, kubura magnesium birashobora kugabanya igipimo cya synthesis ya ATP hejuru ya 60%, kugabanya umuvuduko wubuhumekero, no kongera umusaruro wa ROS, bigatuma mtDNA yangirika nigipimo cya mutation. Kwiyongera kwa magnesium birashobora guhindura imikorere mibi ya mitochondrial. Mu ngirangingo z'imitsi ya skeletale yumuntu hamwe na cardiomyocytes, magnesium nkeya irashobora gutandukanya imbaraga za mitochondrial membrane ishobora gutera, bigatuma hafungurwa pore ya mitochondrial pore (mPTP), bigatuma irekurwa rya cytochrome C, amaherezo iganisha kuri apoptose. Mu ngirabuzimafatizo z'umuntu zifata ingirabuzimafatizo, magnesium nkeya itera umubare munini wa mitochondrial ROS ukoresheje protein kinase C, bigatuma imikorere mibi ya endoteliyale. Ubushakashatsi bwakozwe ku barwayi barenga 100 barwaye syndrome de metabolike bwerekanye ko urugero rwa serumu magnesium rwahujwe neza n’imikorere y’ubuhumekero ya mitochondial kandi rugahuza nabi n’urwego rwa ROS ya mitochondial. Muri make, ibimenyetso byavuzwe haruguru byerekana ko magnesium ari ikintu cyingenzi mu gukomeza homeostasis ya mito-iyambere, kandi imikorere mibi ya mito-iyambere ni bumwe mu buryo bwibanze bwo gusaza.

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Icya gatanu, uruhare rwa magnesium mugutwika indwara zidakira no gusaza k'umudugudu Indwara idakira yo mu rwego rwo hasi ni ikindi kintu cyingenzi cyo gusaza. Ubushakashatsi bwerekanye ko urwego rwibintu bitera umuriro nka IL-6 na TNF-α ku bantu bageze mu za bukuru byiyongereye ku buryo bugaragara, mu gihe urwego rwa cytokine irwanya inflammatory nka IL-10 rwaragabanutse, kandi ibyo bihugu bidakira byatewe no gusaza bizwi nka "inflammaging". Gusaza kwinshi birashobora gutera kwangirika kwinyama no kutaringaniza ubudahangarwa bw'umubiri, ariryo shingiro ryindwara zindwara zidakira. Ubushakashatsi bwakozwe bwerekanye ko kubura magnesium bishobora gutera uburibwe no kudakora neza. Mu mico ya macrophage yimbeba, magnesium nkeya irashobora kugenzura ibikorwa bya NF-κB no guteza imbere irekurwa ryimpamvu zitandukanye. Muri selile epithelia selile yimbeba, ururenda rwa IL-6 na IL-8 rushobora kwiyongera inshuro 2 kugeza kuri 3 kubitera LPS munsi ya magnesium nkeya. Mu ngirabuzimafatizo z'umuntu, magnesium nkeya irashobora gukora inzira ya p38 MAPK yerekana inzira, igatera imvugo ya molekile ya adhesion intercellular selile igenzurwa neza, kandi ikongerera igisubizo. Imbeba zabuze magnesium, urwego rwa TNF-α, CRP na interleukin mu kuzenguruka no mu mitsi rwiyongereye ku buryo bugaragara, ingingo z'umubiri zari atrophy, umubare n'imikorere ya lymphocytes T na B byagabanutse, kandi immunosuppression yariyongereye. Kwiyongera kwa magnesium birashobora kugabanya neza izo ndwara ziterwa no gukingira indwara. Ubuvuzi bwa Clinical bwerekanye kandi ko magnesium nkeya ifitanye isano rya bugufi no gutwika karande. Ubushakashatsi bwibanze ku bantu bakuze barenga 5.000 muri Amerika bwerekanye ko serum magnesium yibanze cyane ku buryo bugaragara hamwe na CRP hamwe n’imibare y’amaraso yera, naho urwego CRP na IL-6 muri quartile yo hasi ya magnesium yari hejuru ya 60% na 40% ugereranije n’izo muri quartile yo hejuru. Isano ryarushijeho gukomera mubantu bafite umubyibuho ukabije. Ubundi bushakashatsi bwakorewe ku bantu 3,200 barengeje imyaka 65 bwerekanye ko urugero rwa serumu magnesium rwahujwe neza nuburebure bwamaraso yera ya telomere kandi bifitanye isano ribi na CRP na D-dimer. Isesengura ryakozwe na 25 ryageragejwe ryateganijwe hamwe nubunini bwikigereranyo cyabantu barenga 2000 ryerekanye ko inyongera ya magnesium yo mu kanwa yagabanije serumu CRP ku kigereranyo cya 22%, TNF-α 15%, na IL-6 kuri 18%. Kubwibyo, inyongera ya magnesium irashobora gutinza gusaza kwumubiri binyuze mu ngaruka zo kurwanya inflammatory.

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Isano igenga hagati ya magnesium na autophagy Autophagy nuburyo bwingenzi bwo kwangirika kw ingirabuzimafatizo no kuvanaho poroteyine na selile zangiritse, kandi ni ngombwa mu kubungabunga homeostasis y’ibidukikije. Ubushakashatsi bwerekanye ko imikorere ya autophagy igenda igabanuka buhoro buhoro mugihe cyo gusaza, kandi inenge muri autophagy zishobora gutera poroteyine, imikorere mibi ya mitochondial, nibindi, kandi byihuta gusaza kwingirabuzimafatizo. Magnesium, nk'intumwa ya kabiri, igira uruhare mu kugenzura itangizwa n'inzira ya autofagy. Mu musemburo, kubura magnesium birabuza kwerekana imiterere ya autofagy ijyanye na Atg1 na Atg13 ukoresheje inzira ya TORC1 yerekana inzira. Mu ngirangingo z’inyamabere, ibidukikije bya magnesium birashobora kubuza ibikorwa bya ULK1, Beclin1 nizindi autofagy zitangiza poroteyine, kandi bikabuza gukora autophagosomes. Mu ngirangingo z'impyiko z'umuntu, magnesium ion chelating agent EDTA irashobora kubuza umuvuduko wa autophagy. Mu bushakashatsi bwa vitro bwerekanye ko intungamubiri za physiologique ya magnesium ion zishobora guhuza no gukora Atg4, enzyme ya proteolyique ikenewe kugirango umuntu akure autophagosome. Ubushakashatsi bw’inyamaswa bwerekanye kandi ko kuzuza indyo yuzuye ya magnesium bishobora kugabanya indwara ziterwa na autofagy muri neuron na cardiomyocytes, kunoza imikorere yubwenge hamwe nimikorere ya sisitemu yumutima. Nubwo habuze ibimenyetso bifatika byubuvuzi, ubushakashatsi bumwe na bumwe bwo kureba bwerekana isano iri hagati ya magnesium na autophagy. Urwego rwa magnesium rwahujwe neza no kwerekana ibimenyetso bya autophagy Atg5 na Beclin1 mu ngingo z'ubwonko hamwe na selile periferique mononuclear selile z'abarwayi bafite indwara ya Alzheimer. Ku barwayi barwaye diyabete yo mu bwoko bwa 2, serum magnesium yibanze cyane bifitanye isano cyane nimiterere ya autofagy ijyanye na genoside LC3 na p62. Mu gusoza, magnesium ishobora kugira uruhare runini mukurwanya gusaza mugutegeka autofagy. Ariko uburyo bwihariye bwayo bugomba kurushaho kwigwa.

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. Ubushakashatsi buherutse gukorwa bwerekanye ko impinduka mu mikorere n'imikorere ya microbiota yo mu nda zifitanye isano rya bugufi no gusaza. Kurugero, igipimo cya firicute na Bacteroide munda yabantu bakuze cyaragabanutse cyane, mugihe umubare windwara ziterwa na virusi nka enterococcus na Staphylococcus wariyongereye. Uku kutaringaniza kw'ibimera kurashobora kwangiza inzitizi yo munda, bigatera kurekura ibintu bitera umuriro, kandi bikongerera umuriro udakira mumubiri wose.

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Nintungamubiri zingenzi zifata munda, magnesium irashobora kugira ingaruka kumiterere yibimera binyuze muburyo butandukanye. Imbeba zitagira mikorobe, amazi yo kunywa akungahaye kuri magnesium arashobora kongera cyane umubare wa bagiteri zifite akamaro nka bifidobacterium na Bacteroide, kandi bikagabanya agaciro ka pH. Muburyo bwimbeba ya colitis, inyongera ya magnesium yagabanije imvururu zo munda zo mu nda kandi byabujije gukora NF-κB mumikorere yerekana ibimenyetso. Mu bushakashatsi bwiza bwabantu, igipimo cya bifidobacteria mumyanda cyiyongereye nyuma yibyumweru 8 byongerewe na magnesium, kandi urugero rwa lipopolysaccharide, aside D-lactique nizindi metabolite za bagiteri zaragabanutse. Ubushakashatsi bumwe bwibanze bwerekanye kandi ko kubura magnesium bishobora guhungabanya amara akomeye, bikongerera ubushobozi, kandi bigatanga uburyo bwo guhinduranya endotoxine ya enterogene.

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Magnesium irashobora kandi guhindura uburyo bwo gusaza kwa nyirarureshwa muguhindura metabolism ya bagiteri. Kurugero, magnesium itera kubyara aside irike ngufi nka Bifidobacterium, ikora G-protein ihujwe na reseptor GPR43, ibuza umubyibuho ukabije hamwe no kurwanya insuline. Byongeye kandi, magnesium irashobora kandi kugira ingaruka kuri aside aside na metabolism ya tryptophan, kandi imivurungano yiyi nzira yombi ifitanye isano rya bugufi nindwara zisaza nindwara zifata ubwonko. Mu gusoza, biteganijwe ko magnesium izaba ingamba nshya zo gutinza gusaza mu guhindura ibimera byo mu nda no kugenga bagiteri-igifu-ubwonko, ariko ingaruka zayo z'igihe kirekire zigomba kugenzurwa n’ubushakashatsi bwakozwe na cohort.

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Muri make, umubare munini wibimenyetso byubushakashatsi na epidemiologiya byerekana ko magnesium nintungamubiri zingenzi zirwanya gusaza no guteza imbere ubuzima no kuramba. Ifite uruhare mukugenzura gusaza binyuze muburyo bukurikira:

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Nubwo ingaruka ziyongera kuri magnesium mubuzima bwabantu muri iki gihe zidashoboka, ibimenyetso bitaziguye byerekana ko magnesium ishobora gufasha gutinza fenotipi nyinshi zishaje kandi bikanoza ibyifuzo byubuzima. Mu bihe biri imbere, ubushakashatsi buteganijwe hamwe n’ibigeragezo byateganijwe birakenewe kugira ngo turusheho gusobanura ingaruka zo kurwanya gusaza kwa magnesium n’umubano w’ingaruka zabyo, kugira ngo hatangwe ibimenyetso bishingiye ku bimenyetso bifatika byerekana ingamba zo kuzuza magnesium. Byongeye kandi, imirire ya magnesium nimirire yabaturage batandukanye ntabwo arimwe, bityo rero gahunda ya progaramu yinyongera ya magnesium nayo nikibazo cyihutirwa gukemurwa. Byizerwa ko hamwe niterambere ryimiti ishaje nimirire, amaherezo tuzavumbura amabanga yose yiki kintu cyitwa magnesium, kandi tuyikoreshe mukurwanya gusaza no gusohoza inzozi zo kuramba.

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