HMB ni metabolite hagati yigihe cya ngombwa cya aside amine acide yumuntu, kandi umubiri wumuntu urashobora kubyara HMB ubwayo. Mu ndyo isanzwe, umubiri wumuntu utanga mg 300 kugeza 400 mg kumunsi, muri zo 90% zikomoka kuri catabolism ya leucine. HMB irashobora gukoreshwa mugutezimbere imitsi, kongera ubudahangarwa, kugabanya cholesterol hamwe nubunini buke bwa lipoproteine ??mumubiri kugirango igabanye indwara zumutima wumutima nindwara zifata umutima, ariko kandi no kongera ubushobozi bwa azote yumubiri, kugumana proteine ??mumubiri, no kwirinda kwangirika kwimitsi kubarwayi baryamye cyangwa bamugaye. Mu myaka yashize, kubera ko ishobora kugabanya kwangirika kwimitsi yimitsi nyuma yimyitozo ngororamubiri, gusana imitsi yimitsi, kongera imbaraga zimitsi no gutwika amavuta yumubiri, yahindutse inyenyeri mubicuruzwa byimirire ya siporo. Byongeye kandi, HMB yerekanwe mubuvuzi yihutisha gukira ibikomere no kubuza gucana. Ubushakashatsi bwerekanye ko Ca HMB ishobora kwihutisha intungamubiri za poroteyine no kugabanya umuvuduko wa poroteyine. Ca HMB ifatanije na glutamine na arginine birashobora kuzamura uburinganire bwa azote bw’abarwayi kandi bikagira uruhare runini mu gukira ihahamuka no kubagwa.

Mu mwaka wa 2011, uwahoze ari Minisiteri y’Ubuzima y’Ubushinwa yatangaje ko hemejwe ko calcium-hydroxy-β-methylbutyrate calcium (Ca HMB) ari ibiryo bishya by’umutungo, gukoresha ibiryo bikomoka ku mirire ya siporo, ibiryo by’ubuvuzi bidasanzwe by’ubuvuzi, amafaranga asabwa ni garama 3 / ku munsi. Muri 2017, Komisiyo y’igihugu ishinzwe ubuzima no kuboneza urubyaro yatangaje ko kwagura ibikorwa bya Ca HMB biva mu byifuzo bibiri byabanje bikagera ku icyenda, kandi hashyirwaho ibigo by’ikoranabuhanga byo gusuzuma ingaruka kugira ngo bisuzume umutekano. Imikoreshereze ya Ca HMB yaguwe ikubiyemo ibinyobwa, amata n’ibikomoka ku mata, ibicuruzwa bya kakao, shokora na shokora, bombo, ibicuruzwa bitetse, n’ibiribwa bidasanzwe by’imirire, kandi amafaranga yasabwaga yari akiri ≤3 g / ku munsi, akaba atarenze urugero rw’abakorerabushake b’ibizamini by’abantu. Ca HMB yamenyekanye nka GRAS n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge mu 1995 kandi ikoreshwa mu biribwa by’imirire y’ubuvuzi ndetse n’imirire idasanzwe. Mu myaka 20 ishize, Ca HMB yakoreshejwe cyane mu bicuruzwa by’amata, ibicuruzwa bya shokora, ibinyobwa, utubari tw’ingufu n’ibindi biribwa ku isoko ry’Amerika. Ca HMB ni ibiribwa bibisi byemewe n’amabwiriza y’Ubuyapani, bishobora kongerwaho mu bice byinshi nk'ibiryo bisanzwe, ibiryo by'imirire ya siporo, ibiryo bigabanya ibiro, ibiryo by'ubwiza, n'ibindi. Birashobora kandi gukoreshwa nk'ibikoresho bikora mu byongera ibiryo nka capsules, ibinini, ibinyobwa bikomeye. Ku bakora na farumasi, Ca HMB kuri ubu ni kimwe mu bintu byubuzima bizwi cyane ku isoko ry’Ubuyapani.