1 mechanism Uburyo bwibanze

Intego ya bagiteri metabolite glyoxylate

Indwara ya bagiteri irwanya ibiyobyabwenge igenga imiterere ya glyoxylate mu ntungamubiri zidafite intungamubiri, igahindura imiterere ya epigenetike, igabanya intege nke z’umubiri, kandi igafasha bagiteri kubaho munsi y’umuvuduko wa antibiyotike ibuza ibikorwa bya ADN demethylase (TET2) mu ngirabuzimafatizo.

Vitamine C ikora ibikorwa bya enzyme ya TET2

Vitamine C, nk'umuntu usanzwe ukora TET2, irashobora kurwanya ingaruka mbi za glyoxylate ku budahangarwa bw'abakira, kugarura imikorere ya ADN ya demethylation, no kongera uburyo bwo kwirinda indwara.

Guhagarika ingamba z "urupfu rwibinyoma" rwa bagiteri

Acetaldehyde icyarimwe ikora uburyo bwo kwirwanaho bwa bagiteri, igakomeza gukomera kugirango birinde antibiyotike. Vitamine C ifatanije na antibiyotike irashobora guhagarika imihindagurikire y'ikirere kandi igabanya cyane imitwaro ya bagiteri.

2 evidence Ibimenyetso byubushakashatsi

Kwemeza icyitegererezo cy’inyamaswa: Mu buryo bwo kwanduza imbeba, guhuza vitamine C na antibiotike byongereye ubuzima bwo kubaho ku kigero cya 60%, bigabanya imitwaro ya bagiteri mu mitsi ku gipimo cya 80%, kandi bigabanya urugero rw’ibibyimba 50%.

Ingaruka ya synergiste: Vitamine C yongerera inzira interferon (IFN) yerekana inzira, ishimangira ubushobozi bwimikorere yumubiri wumubiri wo gukuraho bagiteri zidashobora kurwanya imiti, kandi ikabuza STAT1 dephosifora, ikongerera ubudahangarwa bw'umubiri.

3 potential Amavuriro ashobora gukoreshwa

Kunesha ikibazo cyo kurwanya ibiyobyabwenge: Izi ngamba zitanga imiti mishya iterwa na antibiyotike y’indwara zanduza imiti nka Salmonella na Mycobacterium igituntu, cyane cyane ku barwayi banduye cyangwa antibiyotike zidafite akamaro.

Gahunda yoroshye yo kuvura: Vitamine C, nkintungamubiri zifite umutekano kandi zihenze, zirashobora gukoreshwa zifatanije na antibiyotike zihari kugirango igabanye ibiyobyabwenge kandi bigabanye ingaruka mbi.

Agaciro kiyongera kungingo: Gufata bihagije micrutrients (nka vitamine C) birashobora kugabanya mu buryo butaziguye ibyago byo kwanduza imiti ikomeza kwanduza mikorobe.

4 direction Icyerekezo cy'ubushakashatsi bw'ejo hazaza

Shakisha ingaruka zo guhuza hamwe na dosiye nziza ya vitamine C hamwe na antibiotike nka beta lactams na quinolone.

Suzuma ingaruka ziterwa na vitamine C y'igihe kirekire ku ihindagurika ry’abaturage ba bagiteri irwanya ibiyobyabwenge.

Gutezimbere imiti ya antibacterial yibasira aside glyoxylic-TET2 axis