Lycopene (LYC), karotenoide, ni pigment ibora ibinure, iboneka cyane mu nyanya, watermelon, grapefruit n'izindi mbuto, ni pigment nyamukuru mu nyanya zeze. Lycopene ifite inyungu zitandukanye zubuzima, harimo gusiba radicals yubusa, koroshya umuriro, kugenga glucose na metabolism metabolism, ningaruka za neuroprotective.

Vuba aha, abashakashatsi bo muri kaminuza y’ubuvuzi ya Shanxi basohoye impapuro mu kinyamakuru Redox Biology bise "Lycopene igabanya igihombo kijyanye n’imyaka binyuze mu gukora umwijima-ubwonko. Impapuro z’ubushakashatsi zerekana imikurire ya fibroblast-21 byerekana".

Ubushakashatsi bwerekanye ko kuzuza lycopene mu gihe cy’amezi 3 bishobora gutinza gusaza mu bwonko mu mbeba no kugabanya kwangirika kw’imyaka, kandi lycopene itera kwangirika kw'imitsi, imikorere mibi ya mitochondrial, kwangirika kwa synaptic, kandi igatera guhuza imitsi ya synaptic mu mbeba zishaje.

Byongeye kandi, lycopene yakoresheje umwijima-ubwonko axis FGF21 yerekana imbeba zishaje, bityo bigatuma habaho irekurwa rya neurotransmitter mu kongera urwego rwa mitochondial ATP no kongera synaptic vesicular fusion. Ibi birerekana ko FGF21 ishobora kuba intego yo kuvura ingamba zo gufata imirire kugirango itinde gusaza kwubwonko no kunoza ubumuga bwubwenge.

Mu gusaza, gusaza mu bwonko, imikorere mibi ya mitochondial ni kimwe mu bintu by'ingenzi, abashakashatsi basanze ko inyongera ya lycopene ishobora guteza imbere iyangirika ry’imitsi ya mitochondial, kandi igahindura urwego rw’imikorere ya moteri ya mitochondial iterwa no gusaza, igateza imbere umusaruro wa ATP, byerekana ko lycopene igira ingaruka zo kurinda imikorere ya mitochondial.

Hanyuma, abashakashatsi bakoze kandi mubushakashatsi bwa vitro basanga lycopene yongereye ubushobozi bwingirangingo zumwijima zifasha neuron, harimo kunoza gusaza kwingirabuzimafatizo, kongera imikorere ya mito-iyambere, no kongera uburebure bwa neuron axon.

Ufatiye hamwe, ibisubizo byerekana ko inyongeramusaruro ya lycopene ishobora gutinza gusaza mu bwonko no gukumira ubumuga bwo mu bwenge bujyanye n’imyaka ku mbeba, igice kubera ko lycopene ikora hepato-ubwonko axis FGF21 yerekana, byerekana ko FGF21 ishobora kuba intego yo kuvura indwara ziterwa n’imirire kugira ngo ikureho ubumuga bwo mu mutwe buterwa no gusaza n'indwara ziterwa na neurodegenerative.