Citolineyakoreshejwe cyane mubikorwa byubuvuzi, cyane cyane mu kuvura indwara zifata ubwonko zatewe n’imvune ya craniocerebral cyangwa impanuka y’ubwonko, kandi yabonye uburyo bushya mu buvuzi. Ubuvuzi bwabwo bwo kuva amaraso mu bwonko, indwara ya Parkinson, glaucoma, diabete peripheral neuropathie na tinnitus n'izindi ndwara nazo zagiye zikurura abantu. None citoline ni iki, ni izihe ngaruka za farumasi, ibimenyetso byayo (kuvura neza izo ndwara), efficacy n'umutekano?

Citicoline ni nucleotide imwe igizwe na ribose, cytosine, pyrofosifate na choline. Ni nucleotide ya endogenous yumubiri wumuntu. Ifite inzira nyinshi zingenzi zo guhinduranya umubiri. Nibisanzwe bisanzwe bya fosifolipide synthesis ya neuron selile membrane imiterere kandi ibanziriza biosynthesis ya neurotransmitter acetylcholine.

Citicoline ni imiti ya neuroprotective ishobora kurinda neurone yoroheje, bityo bikagabanya cyangwa bikarinda indwara. Kugeza ubu, imiti ya neuroprotective ikoreshwa cyane mubikorwa byubuvuzi harimo guhagarika imiyoboro ya calcium, glutamate antagonistes, radical scavengers yubusa, hamwe na stabilisateur ya selile, muri byo citoline ikaba ari iy'ingirabuzimafatizo.

Citolineifite intego nyinshi za farumasi, kandi ubwo buryo bwibikorwa butuma bugira amahirwe akomeye muri neuroprotection no gusana imitsi. Ifite neuroprotection yo guhagarika ibibaho byo gukomeretsa ubwonko ningaruka zo gusana imitsi nyuma yo gukomeretsa kwa neuronal, byagura idirishya ryigihe cyo kuvura citoline.

Hashingiwe ku miterere y’imiti, citoline ikoreshwa cyane mu kuvura indwara y’imitsi, ubumuga bwo kutamenya, gukomeretsa ubwonko bw’ubwonko, indwara ya Parkinson, glaucoma, diabete ya peripheri neuropathie, tinnitus n’izindi ndwara, kandi ingaruka n’umutekano byagenzuwe mu bushakashatsi bwinshi bw’ubuvuzi, hamwe n’ibimenyetso bifatika by’ubuvuzi. Indwara ya stroke: ubwonko ni ubwoko bwubwonko bwubwonko bwifunga cyangwa guturika, bikaviramo kwangirika kwubwonko bwicyiciro cyindwara, harimo ischemic na hemorhagic stroke, muribwo ubwonko bwitwa ischemic nubwoko nyamukuru bwubwonko, bingana na 75% kugeza 90% byubwonko bwose. Ibyago byubuzima bwubwonko bwabaturage bacu ni 35% -40.9%, biza kumwanya wa mbere kwisi, sibyo gusa, ubwonko nabwo bwambere butera urupfu nubumuga mubaturage bacu.

Ibimenyetso byubushakashatsi bwamavuriro:

1. Mu 2002, Ikinyamakuru cyo muri Amerika cyitwa Stroke cyasohoye meta-isesengura ry’ibizamini by’amavuriro ku barwayi bafite ikibazo cy’imitsi ikaze, cyerekanaga ko citoline yo mu kanwa yongerera amahirwe abarwayi b’imitsi gukira nyuma y’amezi 3 [1].

2. Mu mwaka wa 2009, ubushakashatsi bwakozwe mu bushakashatsi bw’ibiyobyabwenge bwakorewe muri Koreya yepfo ku barwayi 4191 barwaye indwara y’imitsi ikaze, kandi ibisubizo byagaragaje ko citicoline yazamuye amanota ya NIHSS n’amanota BI y’abarwayi bafite inyungu mu kuvura hakiri kare kandi bitinze, kandi inyungu zo kuvura igihe kirekire zari nyinshi, kandi ingaruka zo kuvura zari zifitanye isano neza na dose. Iterambere ryarushijeho kuba ryiza mu itsinda ryinshi (≧ 2000mg / kumunsi), kandi gusaba igihe kirekire byari bifite umutekano kandi byihanganirwa [2].

3. Ibyavuye mu bushakashatsi bwakozwe na pilote, butabishaka, buhumye-buhumyi, bugenzurwa na platbo ku bijyanye no kuva amaraso mu bwonko bwerekana ko citoline ari umuti wizewe wo kuvura amaraso y’ubwonko kandi ufite ingaruka nziza zo kuvura [3].

4.