SAIB (sucrose isobutyrate acetate) nicyiciro cya farumasi yimikorere myinshi. Nibisukari byamazi byateguwe no kugenzura isukari isanzwe (sucrose) hamwe na acide acike na anhydride ya isobutyric. Nuruvange rwakozwe na distillation hamwe numusaruro usukuye cyane. Irashobora gukoreshwa nkibikoresho bihoraho byo kurekura, solvent / umwikorezi hamwe nibiyobyabwenge.

?

Ibiranga ibicuruzwa bya SAIB

SAIB ni solvent / itwara neza ya hydrophobique API kandi ifite imikorere yo kurekura buhoro.

SAIB ntisiba kandi ikomeza kuba amorphous mubushyuhe bwicyumba, iteza imbere cyane igipimo gihoraho cyo gutanga ibiyobyabwenge;

SAIB ntabwo ari polymeriki kandi ntishobora guterana cyangwa kugwa iyo ihuye namazi yo mumazi. SAIB irashonga mumashanyarazi menshi kandi ahuza nibikoresho byinshi; SAIB irashobora gutatanyirizwa mumazi hifashishijwe ibishishwa kama.

SAIB ifite bioadhesive kandi irashobora gukoreshwa muri transdermal, sublingual na buccal patch.

Gusaba ibicuruzwa

1. Gutinda kurekurwa

Ku gishushanyo kiri hejuru, birashobora kugaragara ko SAIB ifite agaciro ka HLB kangana na 5, byerekana ko ari hydrophobique

2. Amazi mabi yo gukemura API igisubizo

Hydrophobic SAIB ninziza nziza / itwara API ifite amazi mabi, kandi gukoresha SAIB biteza imbere gukemura imiti idashobora gucuruzwa.

3. Irinde kunywa ibiyobyabwenge

Gukoresha SAIB byongera ingano ya opioide mugihe cyo gusya kandi bikabuza gukuramo ibiyobyabwenge.

. Imyiteguro ishyirwa mubikorwa nk'ibidakize / Bidafite umutekano cyangwa ubushyuhe-bwakize / Byakize (byakize 90oC mu minota 30).

. Imyiteguro ishyirwa mubikorwa nkutarakize / udakize cyangwa ubushyuhe-bwakize / Yakize (yakize 90oC muminota 30).

Isuzumabumenyi ryamazuru ryerekanye ko gukoresha SAIB byongereye ingano yifu mugihe cyo gusya, hamwe na 47% yubunini bwifu ya 1mm.

Ugereranije nitsinda rishinzwe kugenzura, amafaranga yo gukuramo SAIB mumazi, 0.1% N HCl na 0.1% N NaOH yumuti wagabanutseho 41.3% -42.5%, 24.8% -26.1% na 37.4% -50,6%. Gukoresha ibishishwa kama kugirango bikurwe bitanga ibisigara bifatanye bigoye kunyura munzira zitandukanye zubuyobozi (urugero, gutera inshinge, kuribwa, gutontoma, nibindi), bikumira ibiyobyabwenge

umwanzuro

Imikoreshereze ya SAIB, idafite igifuniko, irashobora kuvangwa neza na API kugirango irekure ibiyobyabwenge kandi bigere kurekurwa birambye.

Hydrophobic SAIB, ishobora gukwirakwizwa mu mazi hifashishijwe ibishishwa kama, irashobora gukoreshwa na hydrophobique cyangwa hydrophilique apis; SAIB irashobora kunoza ubukana bwa API hamwe no kutagira amazi meza kandi ni igisubizo cyiza kandi gitwara API ifite amazi make.

Ikoreshwa rya SAIB ririnda kunywa ibiyobyabwenge mu kongera ingano y’ibiyobyabwenge iyo biri hasi, bikabangamira kuvoma ibiyobyabwenge, kandi bikagora ko ibiyobyabwenge byinjira mu nzira zitandukanye z’ubuyobozi.

?

http://86671.cn/uruganda-igiciro-saib-sucrose-acetate-isobutyrate-product/