Youdaoplaceholder0 1.1 Ubumaji bwumubiri bwa viscosity gradient: Guhinduka inshuro eshatu kuva Inda ujya kumurongo ?

Imiterere ya molekuline ya polyglucose igizwe nibisigisigi bya glucose bisigara, kandi iri hinduka ryihariye ritanga imiterere yihariye ya rheologiya. Mu bidukikije bifite aside irike cyane mu gifu (pH 1.5-3.5), iminyururu ya molekuline yihuta ikora imiterere y'urusobekerane rw'ibice bitatu binyuze mu mugozi wa hydrogène, kandi ubukonje bwarahise bwiyongera kuri mPa · s 1200 (hafi inshuro ebyiri z'ubuki), bikadindiza neza igipimo cyo gusiba igifu kugera kuri 40% kandi bikongerera ibyiyumvo byuzuye. Nyuma yo kwinjira mu mara mato, nkuko agaciro ka pH kazamutse kugera kuri 6.0-7.5, imigozi imwe ya hydrogène iracika kandi ubukonje bukamanuka kuri 300-500 mPa · s. Ntabwo ibangamira cyane intungamubiri cyangwa ngo ihuze na aside aside kugirango igabanye umuvuduko wa cholesterol. Iyo ugeze mu mara, bitewe na fermentation ya mikorobe, ubukonje burushaho kugabanuka kugera kuri mPa · 50, kurekura aside irike ngufi (SCFAs) kugirango itange ingufu za porotiyotike (Ishusho 1).

?

Youdaoplaceholder0 Inkunga yamakuru ?:

?

Igipimo cyo gutinda cya gastrici: 40% (Ibiryo Hydrocolloide 2022, n = 30)

Igipimo cyo kubuza Cholesterol: 22% (Amakuru yerekana GRAS yo muri Amerika FDA)

Kongera umusaruro wa SCFAs: Kwibanda kuri acide acetike ya colonic yiyongereyeho 3,8 (Gut 2023, Model yinyamaswa)

Youdaoplaceholder0 1.2 "Kugaburira neza" ingamba za microbiome ?

Amabwiriza ya viscosity ya polydextrose ntabwo agira ingaruka kumikorere yumubiri gusa, ahubwo anagira uruhare runini hamwe nibimera byo munda. Imiterere ya viscosity nyinshi ikora inzitizi yumubiri muri colon yegeranye, igabanya imikoranire hagati ya bagiteri itera indwara na mucosa yo munda. Mugihe ibibyimba bigabanuka, buhoro buhoro bihinduka insimburangingo isembuye, cyane cyane itera ikwirakwizwa rya Bifidobacteria na bagiteri ya acide lactique. Itsinda ryaturutse muri kaminuza ya Cambridge ryavumbuye binyuze mu buryo bwa metagenomic ryerekana ko guhora ufata 12g / umunsi wa polydextrose mu byumweru 8 bishobora guhindura igipimo cya F / B cya Thick-miliae / Bacteroidetes kugera kuri 1.3 (hamwe n’ibanze bifite ubuzima bwiza bwa 1.5-2.0), kandi bikongerera ubwinshi bwa bagiteri ya acide butyric (nka Faecalibacterium). Izi ngaruka ebyiri zo "kwirwanaho mbere, hanyuma intungamubiri" zihura neza nibidukikije bikenerwa nibice bitandukanye byinzira zo munda.

?

Youdaoplaceholder0 Igice cya 2 Gushyira mu bikorwa Impinduramatwara: Kwambuka imipaka Kwinjira mu biribwa bigenzurwa nisukari kugeza ku mirire ya ICU ?

Youdaoplaceholder0 2.1 Inganda zibiribwa: "skeleton itagaragara" yibicuruzwa bike bya GI ?

Mu rwego rwo guteka, ubushobozi bwo gufata amazi menshi (> 8g amazi / g) hamwe nubushyuhe bwumuriro (kwihanganira 200 ℃) ya polyglucose bituma isimburwa neza na sucrose. "Zero Sukari Cookies" yatangijwe nitsinda rya Meiji ryu Buyapani ikoresha polyglucose nka fibre yibanze, igera kuri 1,2g gusa ya karubone nziza ya net kuri buri kuki, kandi imiterere na crispness ntaho bitandukaniye nibicuruzwa birimo isukari. Icy'ingenzi kurushaho, ni uko amabwiriza y’ubwiza bwayo mu mara mato ashobora gutinda kwinjiza glucose no kugabanya umuvuduko w’amaraso nyuma y’inyuma ya glucose ku kigero cya 34% (Data Clinical from Diabete Care 2021).

?

Youdaoplaceholder0 Urubanza rushya ?:

?

Youdaoplaceholder0 Nestle:

Youdaoplaceholder0 Nongfu Isoko ?: Yatangije "Amazi Yimbere Yamazi Yumuriro" yongeyeho polyglucose, ikoresha umutungo wacyo wa fermentation nkeya kugirango itange gaze yoroheje mumyanya ndangagitsina kugirango ikangure amara. Yagurishije amacupa arenga miliyoni 100 mumezi atatu.

Youdaoplaceholder0 2.2 Imirire yubuvuzi: "Inzitizi yo mu nda" kubarwayi ba ICU ?

Inzitizi zo mu nda zo kunanirwa ku barwayi barembye akenshi zitera kwandura sisitemu. Ikigeragezo cyateganijwe (n = 158) cyakozwe n’ibitaro bya mbere bishamikiye kuri kaminuza ya Zhejiang byagaragaje ko abarwayi ba ICU bongerewe na 15g za polyglucose buri munsi bagabanutseho 42% by’indwara ya endotoxemiya ndetse no kugabanuka kwa 29% mu mara (plasma ligonin). Uburyo bukoreshwa muburyo leta ifite ubukana bwinshi ikora firime ikingira igifu, bikagabanya ibyago byo kurwara ibisebe biterwa no guhangayika. Acide ya butyric yasohowe nigice cya colonike iteza imbere umubyimba wijimye (kongera umubare wa selile ya goblet 37%), bigashimangira gushimangira inzitizi zibiri zumubiri nubumara.

?

Youdaoplaceholder0 Igice cya 3 Iterambere ryikoranabuhanga: Kuzamura kuva kuri 'Empirical Formulas' ukagera kuri 'Imirire yo Kubara' ?

Youdaoplaceholder0 3.1 Amabwiriza asobanutse yo guhindura molekile ?

Igisubizo cyibisubizo bya polydextrose gakondo ni bike, bigatuma bigorana guhuza neza ibyifuzo byihariye. Muri Kamena 2023, DSM yo mu Buholandi yatangaje ikoranabuhanga ryayo ryemewe "PolySmart ?", ryateje imbere uburyo butatu bwo kugabanuka bw’imitsi igenzura urugero rwa polymerisation (agaciro ka DP) ka glucose na sorbitol:

?

Ubwoko bwa Youdaoplaceholder0 G ? (kongera igifu): Ubushuhe bugera kuri 1500 mPa · s kuri pH

Youdaoplaceholder0 C ubwoko bwa ? (colon-igamije): Viscosity igabanuka cyane kuri 30 mPa · s kuri pH> 6.5, bikundwa kubantu bafite igogora;

Youdaoplaceholder0 Ubwoko B ? (uburyo buringaniye): Guhindura neza kwijimye ryuzuye ryamara, bikwiranye no gucunga glucose yamaraso kubarwayi ba diyabete.

Youdaoplaceholder0 3.2 Igishushanyo mbonera cya AI gifashwa

Ihuriro "FiberEngine" ryakozwe na sosiyete yo muri Isiraheli NutriAI ihuza imibare ya miriyoni 2 zo mu nda ya microbiota hamwe na moderi ya fluid dinamike, ishobora guhanura umubare w’inyongera wa polydextrose mu myaka itandukanye ndetse n’indwara. Kurugero, kubarwayi barwaye IBS (Irritable Bowel syndrome), sisitemu irasaba guhuza buri munsi 8-10g ya polyglucose na 2g ya fructooligosaccharide, ibyo bikaba bigabanya kwandura inda ku kigero cya 65% (2023 ukoresha amakuru akurikirana).

?

Youdaoplaceholder0 Igice cya 4 Imvururu mu nganda: "Fibre Blue Ocean" ibihangange birwanira ?

Youdaoplaceholder0 4.1 Irushanwa ryubushyuhe rirashyuha ?

Biteganijwe ko ingano y’isoko rya polydextrose ku isi izava kuri miliyoni 870 z'amadolari ya Amerika mu 2023 ikagera kuri miliyari 2,1 z'amadolari ya Amerika muri 2030 (CAGR 12.3%). Ubushinwa bwabaye intambara nyamukuru.

?

Youdaoplaceholder0 Baolingbao Bio ?: Shora miliyoni 500 Yuan kugirango wongere toni 30.000 kumurongo wumusaruro, ukoresheje inzira ya synthesis enzymatique kugirango ugere kuri 99.5%;

Youdaoplaceholder0 Rogate ?: Probiotic-polyglucose microcapsules yakozwe kubufatanye na CHR. Hansen yongereye aside irwanya aside igera kuri 90%;

Youdaoplaceholder0 Matsuya Chemie, mu Buyapani ?.

Youdaoplaceholder0 4.2 Ibibazo bibiri byo kugenzura no kumenya ?

Nubwo polydextrose yemerewe kuba fibre yimirire n’ubumwe bw’ibihugu by’Uburayi, Ubushinwa ndetse n’ibindi bihugu, abaguzi baracyafite ubwumvikane buke. Ubushakashatsi bwakozwe na FMCG muri Amerika bwerekana ko 28% byabaguzi aribo bashobora gutandukanya neza itandukaniro ryimikorere hagati ya polydextrose na krahisi idashobora kwihanganira. Ikirenzeho, gufata cyane (> 50g / kumunsi) birashobora gutera uburibwe bwinda cyangwa bikabangamira imyunyu ngugu. Inganda zikeneye byihutirwa gushyiraho umurongo ngenderwaho wa dosiye.

?

Youdaoplaceholder0 Igice cya 5 Urebye imbere: "Umuyoboro wa fibre" kuva GUT kugeza kubuzima bwumubiri ?

Youdaoplaceholder0 5.1 Ibimenyetso bishya byo kugenzura ubwonko-amara axis ?

Mu ntangiriro za 2024, Ishuri Rikuru ry’ikoranabuhanga rya Kaliforuniya ryavumbuye mu bushakashatsi bw’imbeba ko aside ya butyric ikorwa na fermentation ya polydextrose ishobora gutera neurone hypothalamic binyuze mu mitsi ya vagus, bikagabanya imyitwarire isa n’amaganya 43%. Ibi biratanga ibisobanuro kurwego rwa molekuline kubijyanye no kuvuga ngo "indyo yuzuye fibre itezimbere ubuzima bwo mumutwe".

?

Youdaoplaceholder0 5.2 Guhanga udushya muri biologiya ya sintetike ?

Zymergen yatangije muri Amerika yakoresheje ikoranabuhanga rya CRISPR mu guhindura abapasitori ba Trichia, bituma rishobora gusohora mu buryo butaziguye "polyglucose yahinduwe na gene" hamwe n'umurongo wabigenewe. Iki gicuruzwa cyerekanye iterambere rya 80% mubisubizo bya pH mubushakashatsi bwigero bwigero kandi biteganijwe ko bizinjira mubyiciro byubuvuzi muri 2025.

?

Youdaoplaceholder0 Umwanzuro: Kongera gusobanura "imipaka yubwenge" ya Fibre ?

Ingaruka ya viscosity gradient ya polydextrose irerekana ibihe bishya bya fibre yimirire, biva kuri "pasiporo yuzuye" ikajya "kugenzura neza". Mugihe igice cya fibre gishobora kwigenga imikorere yacyo mugusubiza ibyokurya byigifu, dushobora kuba twiboneye ihinduka ryimiterere yubumenyi bwimirire - ingamba zubuzima zizaza ntizizaba imbaraga zonyine za molekile imwe, ahubwo ni imbyino ifatanije nibikoresho byubwenge, mikorobe, nubwenge bwubuhanga. Nk’uwatsindiye igihembo cyitiriwe Nobel muri Chimie, Frances Arnold, yigeze kuvuga ati: "molekile zo muri kamere zisanzwe zifite amahirwe atagira ingano. Icyo tugomba gukora ni ukwiga kumva 'ururimi rwigihe n'umwanya'."