Ubushobozi bwa mannose mubijyanye na farumasi bwibanze cyane mubyerekezo bitandukanye, bimwe muribi bikaba byarakoreshejwe mubuvuzi (nko kwirinda kwanduza inkari), mugihe ibindi biri mubushakashatsi bwibanze cyangwa hakiri kare ibizamini byo kwa muganga. Amahirwe akwiye kwitabwaho, ariko harakenewe ibimenyetso byinshi kugirango ubishyigikire. Sobanura ubushobozi bwayo mubice bikurikira:

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1 、 Kumenyekana / Gukura Kumurima

Kwirinda kwandura kwinkari zinkari (rUTI) ?

Mechanism: Gutanga umunwa wa mannose bivamo gusohora cyane mu nkari, bikabuza guhatanira guhuza FimH pilin adhesine ziterwa na virusi nka Escherichia coli na selile epithelial selile, bikabuza bagiteri gukoronizwa no gukaraba inkari.

Ibimenyetso:

Ubushakashatsi bwinshi bw’amavuriro, nko kugereranya na antibiotique furantoin, bwerekanye ko 1.5-2g ya mannose ku munsi ikora neza nka antibiotike nkeya mu gukumira rUTI iterwa na Escherichia coli ku bagore, kandi ifite ibyago bike byo guhangana.

Amabwiriza y’ishyirahamwe ry’ibihugu by’i Burayi (EAU) ayashyira ku rutonde nk’uburyo bwo gukumira rUTI (Urwego rwibimenyetso: B).

Ibyiza: Umutekano muke (ingaruka mbi za gastrointestinal), nta ngaruka zo kurwanya antibiyotike yagutse.

Imipaka: Gusa ikoreshwa mugukumira kandi ntishobora gusimbuza antibiyotike mukuvura indwara zikaze; Ingaruka kuri Escherichia coli UTI ni nto.

2 、 Uturere turi murwego rwubushakashatsi ariko dufite ubushobozi busobanutse

Kuvura Indwara ya Glycation Yavutse (CDG)

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Mechanism: Bimwe mubisobanuro bya CDG, nka MPI-CDG (ubwoko bwa CDG-Ib), ntibibura fosifomannose isomerase (PMI), birinda ihinduka rya mannose-6-fosifate na fructose-6-fosifate, bigatuma habaho kunanirwa kwingingo nyinshi.

Umuti: Gutanga umunwa wa mannose birashobora kurenga inenge za PMI kandi bigatanga mu buryo butaziguye mannose-6-fosifate, ikagarura synthesis ya glycoproteine.

Ibiriho ubu:

FDA yemeje ikoreshwa rya mannose kuri MPI-CDG, ikaba ari imwe mu moko make ashobora kuvurwa ya CDG.

Iterambere rikomeye ryindwara zumwijima, imikorere mibi ya coagulation, nibimenyetso bya gastrointestinal, ariko birakenewe imiti ubuzima bwawe bwose.

Ibishoboka: Shakisha agaciro kavura kubindi bisobanuro bya CDG, nka ALG-CDG.

Kurwanya immunite no gutanga ibiyobyabwenge ???? (Ubushakashatsi bwibanze)

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Urwego:

Ibibyimba byibasiwe na microen ibidukikije: Tumor ifitanye isano na macrophage (TAMs) yerekana cyane reseptor ya mannose (MRC1), kandi imiti yahinduwe na mannose irashobora gushyikirizwa ibibyimba muburyo bugamije.

Kugenga guhagarika ubudahangarwa bw'umubiri: Mannose irwanya irushanwa ryakira mannose hejuru ya TAM, bikabuza kumenya antigene ya mannose glycated hejuru ya selile yibibyimba, bishobora guhindura ubudahangarwa bw'umubiri.

Kongera imiti ya chimiotherapie: Mu bushakashatsi bw’inyamaswa, guhuza mannose na chimiotherapie (nka doxorubicin) birashobora kubuza cyane imikurire yikibyimba (bishoboka ko bivanga na glucose metabolism).

Ikibazo: Ubushakashatsi burakenewe kubijyanye nubushobozi bwabantu, dosiye nziza, hamwe na sisitemu yo gutanga.

Indwara ya antifungal / antiparasitike yanduye ??

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Mechanism: Indwara nka Candida albicans na Plasmodium zishingira reseptor ya mannose yakira selile. Mannose irashobora guhagarika ifatira ryayo.

Ubushakashatsi:

Muri vitro n’inyamanswa zerekanye ko mannose ishobora kubuza Candida kwizirika ku ngirabuzimafatizo.

Gukoresha hamwe n'imiti igabanya ubukana birashobora kugabanya umuvuduko wanduye wa malariya (ubushakashatsi bwinyamaswa).

Ibishoboka: Nkumuti wogutezimbere imikorere yimiti irwanya kwandura no kugabanya kurwanya ibiyobyabwenge.

3 direction Icyerekezo gishya cyubushakashatsi (ubushobozi bwo kugenzurwa)

Indwara yo mu mara (IBD) no gusana inzitizi zo munda ??

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Ibitekerezo:

Mannose irashobora kugenga mikorobe yo mu nda (guteza imbere bagiteri zifite akamaro) no kubuza bagiteri gutera indwara.

Kongera imikorere ya poroteyine zo mu nda zo mu nda binyuze mu guhindura glycosylation.

Ibihe byubu: Moderi yinyamanswa (colitis) yerekana ingaruka zimwe zo gukingira, ariko ubushakashatsi bwabantu burabuze.

Kugena indwara ziterwa na autoimmune ??

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Igitekerezo: glycosylation idasanzwe igira uruhare mu gutera indwara ya rubagimpande ya rubagimpande, lupus, nizindi ndwara. Mannose inyongera irashobora gukosora inenge ya glycosylation.

Iterambere: Byagaragaye gusa mubyitegererezo by'akagari cyangwa umubare muto cyane w'imanza, nta bigeragezo bikomeye byo kwa muganga.

Kwirinda ingorane za diyabete ??

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Logic: Isukari nyinshi mu maraso itera glycation ikabije idafite imisemburo (AGEs) ya poroteyine, itera ingorane. Mannose metabolism ntabwo iterwa na insuline kandi ntabwo igira ingaruka kumaraso ya glucose, cyangwa irashobora kugabanya irushanwa rya AGEs.

Ibimenyetso: Ubushakashatsi bw’inyamaswa bwerekana ko iterambere rya diabete ya nepropatique itinda, kandi ubushakashatsi bwabantu ni ubusa.

4 、 Inzitizi n'imbogamizi

Inzitizi nyamukuru murwego

Kwirinda UTI ntacyo bikora kurwanya virusi ya Escherichia coli; Amakuru yigihe kirekire yumutekano ntahagije (cyane cyane ingaruka zimpyiko)

Kuvura CDG bifite akamaro gusa muburyo bwihariye; Gusuzuma hakiri kare n'imiti ubuzima bwawe bwose birakenewe

Ingaruka zo kuvura ibibyimba mumubiri wumuntu ntizwi; Umubare munini urashobora gutera impiswi; Ibyago byuburozi bwo guhuza chimiotherapie bigomba gusuzumwa

Imikorere idahagije yo gukoresha inshuro imwe imiti igabanya ubukana; Ukeneye kunonosora imiti hamwe nibiyobyabwenge bihari

Intege nke zubushakashatsi ku bundi buryo bugaragara; Kutagira ibizamini byo mu rwego rwo hejuru byujuje ubuziranenge; Benshi muribo baguma murwego rwicyitegererezo cyinyamaswa

5 direction Icyerekezo cy'iterambere ry'ejo hazaza

Sisitemu yo gutanga neza neza: Shushanya mannose yahinduwe nanocarrier kugirango yongere ibibyimba / kwandura indwara.

Gukoresha uburyo bwiza bwo kuvura: gushakisha ingaruka ziterwa na mannose hamwe na antibiotike, imiti igabanya ubukana, hamwe n’imiti igabanya ubukana.

Kwiyongera kw'indwara zidasanzwe: Kugaragaza ubundi bwoko bwa CDG hamwe nububiko bwa lysosomal bushobora kuvurwa na mannose.

Gukora igihe kirekire-kurekura: gukemura ikibazo cyimiti ikunze gukoreshwa (nko gukoresha burimunsi mukurinda UTI).

Ingamba zo gutondekanya abaturage: imiti itomoye ishingiye ku bwoko bwa patogene (UTI) cyangwa ihinduka rya gene (CDG)