Vitamine B3, izwi kandi ku izina rya niacin, ni vitamine ishonga mu mazi ikora imirimo itandukanye y'ingenzi mu mubiri. Ubushakashatsi bwakozwe mbere bwerekanye ko vitamine B3 igira uruhare mu mikorere y’umubiri y’umubiri, igatera metabolisme y’uturemangingo tw’uruhu, kandi ikagira n'ingaruka zimwe na zimwe za antioxydeant.

Indwara y’umwijima idafite inzoga (NAFLD), ni yo ikunze kugaragara cyane mu bwoko bw’indwara zidakira z’umwijima mu Bushinwa, mu Bushinwa hari abarwayi barenga miliyoni 150, muri bo 10-20% bazakomeza kwandura indwara ziterwa na alcool (NASH), ahanini zigaragazwa no gutwika no kwangirika kw’umwijima, akenshi bikajyana na fibrosis. NASH itera imbere byihuse kandi ifite ibyago byinshi byo kwandura indwara zikomeye zumwijima nka cirrhose na kanseri yumwijima.

Vuba aha, abashakashatsi bo mu ishuri ry’ubuzima rusange muri kaminuza ya Sun Yat-sen basohoye urupapuro mu kinyamakuru JAMA Network Open cyiswe "Kurya Dietary Niacin no gupfa mu bantu bafite inzoga nyinshi. Indwara y’umwijima".

Ubushakashatsi bwerekanye ko kongerwamo vitamine B3, cyangwa kugabanya ibyago by’impfu zose ziterwa n’abarwayi bafite umwijima w’umwijima utarimo inzoga, byajyanye no kugabanuka kwa 30% by’impfu ziterwa n’impamvu zose ku bitabiriye amahugurwa menshi (≥ 26.7mg / ku munsi) ugereranije n’abitabiriye gufata bike (≤18.4mg / ku munsi).

Muri ubu bushakashatsi, abashakashatsi basesenguye isano iri hagati yo gufata vitamine B3 y’ibiryo ndetse n’impanuka ziterwa n’impfu zose z’abarwayi bafite indwara y’umwijima y’amavuta y’inzoga bakusanya vitamine B3 y’ibiryo bivuye mu bushakashatsi bw’ubushakashatsi bw’ubuzima n’imirire (NHANES) bw’abarwayi 4.315 ba NAFLD bafite impuzandengo y’imyaka 53.

Abitabiriye amahugurwa bagabanyijwemo amatsinda atatu ashingiye ku gufata vitamine B3: itsinda rito (≤ 18.4mg / kumunsi), itsinda rito (18.5-26.6mg / kumunsi) hamwe nitsinda ryinshi (≥26.7mg / kumunsi).
Mu gihe cyo gukurikirana hagati y’imyaka 8.8, hapfuye abantu 566, 197 muri bo bakaba baratewe n'indwara z'umutima.

Isesengura ryerekanye ko abitabiriye gufata abantu benshi bafite ibyago 30% by’impfu zose ugereranije n’abitabiriye gufata bike.

Byongeye kandi, abitabiriye amahugurwa menshi bagabanutseho 35 ku ijana by’impfu z’umutima n’imitsi, ariko ntabwo byari bifite imibare.

Isesengura ryakozwe ryagaragaje imikoranire igaragara hagati yo gufata vitamine B3 n’ingaruka za diyabete ndetse n’impfu zose, hamwe n’igabanuka ryinshi ry’imfu ku barwayi batari diyabete ugereranije n’abafite diyabete.

Abashakashatsi bavuga ko niacin ari kimwe mu bibanziriza synthesis ya NAD kandi yabaye intego ikomeye yo gukumira no kuvura indwara z’umwijima. Ubushakashatsi bwakozwe ku baturage bwerekanye kandi ko niacin ishobora kunoza umwijima kandi igabanya ibinure by umwijima. Mu bushakashatsi bwibanze, niacin yasanze ibuza kandi igahindura umwijima umwijima no gutwika, no kwirinda fibrosis. Izi ngaruka zigerwaho mukugabanya imbaraga za okiside, kubuza diacylglyceryl acyltransferase 2 na NADPH oxydease, nubundi buryo bushoboka.

Twabibutsa ko muri Nzeri 2023, Abashakashatsi bo mu Ishuri Rikuru ry’Ubuzima rusange muri kaminuza ya Sun Yat-sen basohoye urupapuro mu kinyamakuru Nutrients bise "Ishyirahamwe hagati ya Dietary Niacin Intake na Nonalcoholic Fatty Disease: NHANES 2003-2018" impapuro z’ubushakashatsi.

Ubushakashatsi bwerekanye ko inyongera ya vitamine B3 ifitanye isano n’impanuka nke z’indwara z’umwijima zidafite inzoga, hamwe n’abafite niacin nyinshi (≥29.2mg / ku munsi) bafite ibyago byo hasi ya 31% by’indwara z’umwijima zidafite inzoga ugereranije n’abafite niacine nkeya (≤16.3mg / ku munsi).

Ufatiye hamwe, ibisubizo byerekana ko inyongera ya vitamine B3 ifitanye isano n’impanuka nke z’indwara z’umwijima zidafite inzoga n’igabanuka ry’impfu zose ziterwa n’abarwayi bafite umwijima w’umwijima udafite inzoga. Ubushakashatsi burakenewe kugira ngo hemezwe urugero rwiza rwa vitamine B3 kugira ngo ugabanye ibyago byose by’urupfu ku barwayi barwaye NAFLD.