Indwara y'umwijima w'inzoga (ALD), ni indwara y'umwijima iterwa no kunywa igihe kirekire, ni imwe mu ndwara zikunze kwibasira umwijima mu Bushinwa, zirimo umwijima w'amavuta w'inzoga, hepatite y'inzoga, fibrosis y'umwijima na cirrhose. Mu myaka yashize, ubwiyongere bw’indwara z’umwijima z’inzoga bwerekanye ko Ubushinwa bugenda bwiyongera.

Ku ya 2 Nyakanga 2024, Liu Zhihua wo muri kaminuza ya Tsinghua, Wang Hua wo muri kaminuza y’ubuvuzi ya Anhui, Yin Shi wo muri kaminuza y’ubumenyi n’ikoranabuhanga mu Bushinwa n’abandi bashakashatsi basohoye inkuru yise "Fibre fibre igabanya imvune y’umwijima y’inzoga ikoresheje" mu kinyamakuru Cell Host & Microbe "Bacteroides asideifaciens na disoxification ya ammonia".

Indyo ikungahaye kuri fibre fibre fibre yabonetse kugirango yongere ubwinshi bwa B. accidifaciens no kugabanya imvune ziterwa numwijima ziterwa nimbeba.

Kuri ubwo buryo, B.accifaciens igenga metabolisme ya aside aside ikoresheje enzyme ya saline hydrolysis enzyme (BSH). Ubwiyongere bwa aside aside idahuza ikora inzira ya FXR-FGF15 mu mara, irinda imikorere yinzitizi yo munda, iteza imbere imvugo ya ornithine aminotransferase (OAT) muri hepatocytes, bityo igatera metabolisme ya ornithine yegeranijwe mu mwijima kugirango glutamate. Tanga ibikoresho fatizo byo kwangiza umwijima no kugabanya kwangirika kwumwijima.

ubu bushakashatsi, abashakashatsi babanje gutera indwara yumwijima yinzoga muburyo bwimbeba kandi banasesengura ingaruka za fibre yibiryo byindwara yumwijima w’umwijima ku mbeba hiyongeraho fibre ibora kandi idashonga.

Ibisubizo byagaragaje ko inyongeramusaruro zuzuye za fibre fibre zongereye cyane indwara zumwijima zinzoga ku mbeba, harimo kugabanya umwijima w’umwijima no kugabanya ijanisha n’umubare rusange w’umwijima neutrophile, mu gihe fibre yibiryo idashobora kugira ingaruka zikomeye.

Kubera ko fibre yimirire ishobora kugira ingaruka zikomeye kuri mikorobe yo mu nda, abashakashatsi bakomeje gusesengura niba iterambere ry’indwara y’umwijima y’inzoga ryatewe na mikorobe yo mu nda hakoreshejwe uburyo bwo guhinduranya mikorobe.

Nyuma yo guhindurwa, byagaragaye ko guhindagura microflora yimbeba zagaburiwe fibre yibiryo byigabanije byagabanije serum alanine aminotransferase (ALT) hamwe na aminotransferase (AST), mugihe kugabanya umwijima wumwijima no gutwika, byerekana ko fibre yibiryo ishobora guhinduka muguhindura imiterere ya microflora yo munda.

Ubushakashatsi bwerekanye ko fibre fibre fibre fibre yatezimbere umwijima w'ingirabuzimafatizo ya necrosis, umwijima wo mu mwijima no gutwikwa mu buryo bw'imbeba y’indwara y’umwijima y’inzoga, kandi inagabanya urugero rw’amaraso amoniya hamwe n’ingutu ya okiside, byerekana uruhare rukomeye rw’imirire y’ibiryo byoroshye mu gukumira no kuvura indwara z’umwijima w’umwijima.

Ni ngombwa kumenya ko muri rusange abantu bakuru basabwa kurya garama 25-30 cyangwa nyinshi za fibre yimirire kumunsi, ariko abantu benshi ntibujuje ibyifuzo byimirire. Ibinyampeke, imbuto n'imboga ni isoko ikungahaye kuri fibre y'ibiryo kandi irashobora gutanga izindi micronutrients.

Muncamake, ibisubizo byerekana ko indyo ikungahaye kuri fibre yibiryo byoroshye ishobora kunoza umwijima uterwa ninzoga muburyo bwimbeba mugihe urinda ubusugire bwinzitizi y amara. Ubu bushakashatsi bufite agaciro k’amavuriro n’akamaro k’imibereho.

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