Kanseri ya prostate (PC), imwe muri kanseri ikunze kugaragara ku bagabo, ni nk'umwicanyi ucecetse, abarwayi benshi bagaragaza ibimenyetso bikura buhoro buhoro by'indwara zishobora kuvamo kanseri yangiza ubuzima. Icyo gihe, kanseri ya prostate irashobora guhinduka kuburyo buryo bwose bwo kuvura butaboneka.

Nkuko baca umugani, kuvura biterwa n "ingingo eshatu zubuvuzi, ingingo zirindwi zo kubungabunga", iyi "kubungabunga" umwanya munini yerekeza ku biryo byangiza ibiryo. Kanseri ya prostate ni indwara ndende itera imbere. Niba uburyo bukwiye bwo gutabara, nkubuzima bushyize mu gaciro nimirire, bushobora gukoreshwa mugihe cyambere cyindwara, birashobora kudindiza neza iterambere rya kanseri ya prostate kandi bigateza imbere abarwayi.

Ku ya 25 Ukwakira 2024, itsinda rya Porofeseri Lloyd Trotman wo muri Laboratoire ya Cold Spring Harbour ryasohoye mu kinyamakuru mpuzamahanga cy’ubumenyi mpuzamahanga cyitwa Science cyiswe: Dietary pro-oxidant therapy na vitamine K ibanziriza PI 3-kinase VPS34 urupapuro rwubushakashatsi.

Ubushakashatsi bwerekanye ko inyongera ya okiside, menadione (vitamine K3), ishobora kudindiza iterambere rya kanseri ya prostate. Menadione ni intangiriro y'amazi ya vitamine K, ikunze kuboneka mu mboga rwatsi rwatsi, kandi imikorere ya physiologique ni uguteza imbere gutembera kw'amaraso no kugira uruhare mu guhindura amagufwa.

Ubushakashatsi bwakozwe na Mechanism bwerekanye ko VPS34 ari intego nyamukuru ya phosphatidylinositol 3-kinase (PI3K), menadione irashobora guhagarika ibikorwa bya VPS34, kugabanya umusaruro wa PI3P, no kongera imbaraga za okiside itera urupfu rwa selile kanseri ya prostate. Ibinyuranye, selile zisanzwe zikura buhoro bityo zikaba zifite ingufu zihagije zo guhangana niki cyangiritse. Byongeye kandi, itsinda ry’ubushakashatsi ryerekanye ko menadione nayo igira ingaruka zo kuvura indwara yica abantu yitwa X-ihuza myotubulin myopathie (XLMTM).

Ubu bushakashatsi bugaragaza inzira yoroshye ariko ifatika yo kwivanga muri kanseri kandi ikagira ingaruka nshya mu kuvura izindi ndwara zishingiye ku ngirabuzima fatizo ziterwa no kudashyira mu bikorwa ibikorwa bya kinase.

Iri tsinda ryavuzaga imiterere y’imbeba ya RapidCaP hiyongereyeho poroteyine, menadione sodium sulfite (MSB), uruganda rukaba rw’inyamabere ibanziriza vitamine K. Basanze ko buri munsi inyongera ya MSB mu mazi yo kunywa ishobora kubuza iterambere rya kanseri ya prostate kandi bikagira ingaruka zirambye zo kubuza.

Muri rusange, ubushakashatsi bwasohotse mu bumenyi, bugaragaza ko kongera inyongera ya poroteyine mu mafunguro kugira ngo zongere MSB zishobora gutinza neza indwara ya kanseri ya prostate. Ni ukubera ko MSB ishobora guhagarika ibikorwa bya PI3K kinase VPS34, kugabanya umusaruro wa PI3P, no kongera imbaraga za okiside, biganisha ku rupfu rwa kanseri ya prostate. Byongeye kandi, muri X ihuza myotubular myopathie (XLMTM), MSB irashobora guhagarika ibikorwa bya kinase ya VPS34, igasubiza PI3P kurwego rushobora guteza imbere imitsi.