Sucralose isimbura isukari. Nibikoresho bikoreshwa cyane. Abantu bakunze kwikuramo isukari kuko itanga uburyohe ariko ntibirimo karori iboneka mubisukari kumeza. Sucralose ikoreshwa nkibigize ibiryo n'ibinyobwa, akenshi bigurishwa nk "" isukari idafite isukari "cyangwa" kugabanya ibiro "kugirango igabanye karori muri rusange.

Sukrose ni iki?

Sucralose nikoreshwa cyane ridafite intungamubiri, zero-calorie nziza. Sucralose ikozwe muburyo bwa artificiel kuva kumasukari yameza (isukari yameza) binyuze munzira nyinshi zisimburanya gusimbuza amatsinda atatu ya hydroxyl muri molekile yisukari na atome eshatu za chlorine. Nyuma, byahanaguwe kugeza kuri 98%. Ihindurwa ryimiti ryemeza ko sucralose iryoshye inshuro 600 kuruta isukari yameza. Igicuruzwa cyanyuma ni cyera, kristaline, ikora neza cyane uburyohe bwa artile ibora cyane mumazi. Isukari nyinshi ya Sucralose mumazi ituma biba byiza kwinjizwa mubiribwa bitandukanye bitunganijwe: ibicuruzwa bitetse, ibinyobwa, guhekenya amenyo, gelatine, hamwe nubutayu bwamata bwakonje. Abantu bashaka ubundi buryohe buryoshye mubisanzwe bahitamo sucralose kubindi biryoshye nka artartame na sakarine. Nkibikomoka ku isukari yo kumeza, sucralose igumana uburyohe bwayo bumenyerewe "busa nisukari", mugihe cyane cyane kubura uburyohe bwakera busanzwe kubandi basimbuye isukari. Uburyohe bukomeye bwa sucralose butuma umubare muto ujya munzira ndende, bigatuma uhitamo gukundwa cyane nimirire ya calorie nkeya. Kwinjira kwa sucralose mu nzira ya gastrointestinal ni ntoya, kandi inzira nyamukuru yo gusohoka ni sucralose idahinduwe mu ntebe. Kubwibyo, nta nzira ya catabolika (breakdown), yemeza ko sucralose atari isoko yingufu na / cyangwa karori. Imiterere yo kwemeza no kugenzura sucralose yemejwe bwa mbere gukoreshwa muri Kanada mu 1991, ikurikirwa na Ositaraliya mu 1993 na Nouvelle-Zélande mu 1996. Mu 1998, Ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA) cyemeje sucralose yo gukoreshwa mu byiciro 15 by’ibiribwa n’ibinyobwa, inagura imikoreshereze yacyo nk'ibiryohereye mu biribwa muri 1999. Sucralose yemerewe gukoreshwa nk'inyongeramusaruro y'ibiribwa mu bihugu by’Uburayi mu 2004. Mu itegeko ry’ibiribwa, ibiyobyabwenge, no kwisiga, ibijumba bigomba kuba byiza kurya. Icyemezo cy’umutekano wa FDA gishingiye ku bushakashatsi bwimbitse bw’inyamaswa n’ibizamini by’amavuriro bisuzuma uburozi, teratogenicite (ubushobozi bwo gutera indwara mbi mu gihe cyo gutwita), na kanseri. Dukurikije ibyifuzo bya FDA, urwego rwemewe rwo gufata buri munsi (ADI) rwa sucralose muri Amerika rushyirwa kuri 5 mg / kg uburemere bwumubiri kumunsi (mg / kg / kumunsi). Inyungu zishoboka zo gukoresha sucralose mugucunga ibiro bitarimo calorie

Bitandukanye nisukari yameza, sucralose ntabwo igogorwa cyangwa ngo isenywe mumitsi yigifu kandi ntabwo ikora nka lisansi ya caloric mumibiri yacu. Sucralose rero ni amahitamo azwi kubantu bashaka gusimbuza isukari yo kumeza (ikiyiko 1 cyangwa garama 4.2 z'isukari yo kumeza irimo karori 16) no kugabanya ikoreshwa rya kalori yose. Mugushyiramo sucralose mumirire yabo, abantu barashobora guhaza ibyo bakeneye bitabaye ngombwa ko bahangayikishwa na karori yinyongera, ningirakamaro mugucunga ibiro.

Birakwiye gucunga diyabete

Sucralose ntabwo ihindurwa n'imibiri yacu kugirango ibone ingufu kandi ntabwo itera kwiyongera k'isukari mu maraso (6). Hashingiwe ku bushakashatsi bw’ubuvuzi bwa sucralose ku bantu barwaye diyabete, FDA yanzuye ko sucralose itagira ingaruka mbi ku kugenzura isukari mu maraso mu gihe gito ku bantu barwaye diyabete yo mu bwoko bwa 2. Byongeye kandi, ubushakashatsi bwakozwe ku mavuriro bwerekanye ko sucralose itagira ingaruka kuri glucose homeostasis y'igihe kirekire (nkuko byapimwe na HbA1c glycosylation) ku barwayi barwaye diyabete yo mu bwoko bwa 2. Kubwibyo, sucralose nuburyo bwiza bwo kuryoshya abarwayi ba diyabete bagumana indyo yuzuye ya karbasi. Nubwo bimeze bityo ariko, kimwe nuburyo bwo guhitamo indyo yuzuye, abantu barwaye diyabete bagomba kugisha inama umuganga w’imiti wuzuye cyangwa ukora kugirango abone gahunda yimirire yihariye mugihe akurikirana ibyago byo kwandura hypoglycemia ituruka ku gufata sukalose. Ibibazo byubuzima bishobora kubaho ningaruka Nubwo sucralose yasuzumwe kubwumutekano nabashinzwe kugenzura umutekano, umutekano wa sucralose ningaruka zishobora kugira ku buzima bikunze kugibwaho impaka. By'umwihariko, ubushakashatsi bw’uburozi busuzuma ingaruka ziterwa na glucose, neurotoxicity, na kanseri itera inyamaswa akenshi bitera kwibeshya.

Ubushakashatsi bwerekanye ko uburyohe bwa artile, harimo na sucralose, butera ururenda rwa insuline hamwe na reseptor nziza zerekanwa ku ngirabuzimafatizo za beta muri pancreas, cyane cyane iyo glucose idahari. Sucralose nayo yerekanwe gutera GLP-1. GLP-1 ningirakamaro kuri glucose homeostasis kandi muri rusange izamura glucose-yunganiwe na insuline. Igihe kirenze, kwiyongera kwa insuline mumaraso nyuma yo guhura na sucralose amaherezo birashobora gutuma insuline irwanya bitewe no kugabanya ibikorwa bya reseptor. Kwangirika kwa glucose homeostasis (kugenga urugero rwisukari mu maraso) no kugabanya ubukana bwa insuline nibintu byingenzi bifitanye isano nindwara ziterwa na metabolike. Kuba udashobora gukomeza gufata glucose neza bigahungabanya kugenzura isukari mu maraso kandi biganisha ku iterambere ry’indwara ziterwa na diabete yo mu bwoko bwa 2, umubyibuho ukabije, na dyslipidemiya. Byongeye kandi, ibyago byo kwandura indwara z'umutima-damura byiyongera cyane. Ingaruka ku buzima bwo munda na microbiome Sucralose ifatwa nk "inert metabolically inert" kubera ko idashizwemo ahubwo isohoka neza mu ntebe. Ibi bituma bidashoboka kuba substrate ya microbiome yo munda. Ariko, hari ibimenyetso byerekana ko guhura na sucralose bishobora guhindura mu buryo butaziguye microbiota yo mu nda binyuze mu kugabanuka kw'isukari mu maraso cyangwa igisubizo gishobora gukingira indwara. Ubushakashatsi bwinshi bw’inyamaswa bwerekanye ko kurya ibinyamavuta bidafite intungamubiri (NNS) bishobora gutera mikorobe zo mu nda; Yerekanye ubwinshi bwa bagiteri zitera indwara hamwe no kugabanuka kwinshi kwa bagiteri zifite akamaro. Ariko, gutandukanya amakuru yinyamaswa kubantu bigomba gukorwa neza, kuko gukoreshwa mubuzima bwabantu nindwara bishobora kuba bike. Igeragezwa rya clinique ryakozwe hagamijwe gukora ubushakashatsi ku ngaruka ziterwa no gufata igihe gito (iminsi 14 yumunsi wumye) zifata sucralose kuri glucose metabolism nazo zagaragaje ingaruka ziterwa no gufata buri munsi NNS kuri microbiota yo munda. Ubushakashatsi bwanzuye ko sucralose itateje impinduka zikomeye mubutunzi bwa microbiota cyangwa nimugoroba. Ku rundi ruhande, ikindi kigeragezo kigufi cyateganijwe cyerekanwe ko kuzuza imirire hamwe na NNS bishobora kugira ingaruka kumikorere ya mikorobi ya muntu, hamwe na sucralose igira ingaruka zikomeye. Icyakora, ni ngombwa kumenya ko ibizamini by’amavuriro byombi byasuzumye ingaruka z’inyongera ya NNS mu gihe gito (harimo na sucralose), kandi hakenewe igihe kirekire kugira ngo dusobanukirwe neza ingaruka z’ubuzima bw’inyongera ya NNS kuri mikorobe y’umuntu. Ingaruka ndende za sucralose nizindi NNS kuri microbiome yumuntu ni agace k'ubushakashatsi bukomeje.

Ibice bya neurologiya hamwe no kugaburira ibyokurya Nubwo sucralose ifatwa nka karori idafite imbaraga, itera uburyohe bwakira uburyohe, itera imisemburo ya insuline muri pancreas, ikanatangira kasike ya metabolike yigana uko kurya. Mugihe glucose idahari, gusohora kwa insuline guhora byongera imbaraga za metabolike hamwe na chimie yubwonko. Uburyohe bwacu burashukwa twibwira ko turya isukari nyayo. Mu igeragezwa ryateganijwe, abategarugori bafite umubyibuho ukabije bagaragaje ibikorwa byiyongera mu turere tw’ubwonko bujyanye no gusubiza ibiryo no gutunganya ibihembo, bigatuma intungamubiri ziyongera nyuma yo kurya sucralose. Ubu bushakashatsi butanga ibimenyetso bifatika byerekana ko kunywa ibinyobwa bya sucralose nibindi biryoha bijyana no kongera ubushake bwo kurya no kwifuza, kurya cyane, no kwiyongera ibiro hamwe n'umubyibuho ukabije.