D-mannose na L-mannose ni enantiomers zerekana indorerwamo, kandi itandukaniro ryabo ryingenzi riri muburyo butandukanye bwa stereoconfigurations, bikavamo ibikorwa nibikorwa byibinyabuzima bitandukanye cyane. Ibikurikira ningenzi byingenzi bitandukanya ingingo:

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1. Itandukaniro ryibanze mumiterere yimiti

Ingingo rusange:

Inzira ya molekuline ni C ? H ?? O ?, ikaba ari C-2 isomer ya glucose (ni ukuvuga icyerekezo cya hydroxyl (- OH) kuri karubone ya kabiri ihabanye na glucose).

Itandukaniro nyamukuru:

Uburyo bwa D / L bwerekana uburyo bushingiye kuri sisitemu ya glyceraldehyde:

D.

L-mannose: Icyerekezo cya hydroxyl ya C5 gihuye nicyerekezo cya L-glyceraldehyde (giherereye ibumoso muri projection ya Fischer).

Byombi ni indorerwamo ishusho yundi kandi ntishobora guhuzagurika. ?

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Ikigereranyo cya Fischer: kugereranya imiterere hagati ya D-mannose (ibumoso) na L-mannose (iburyo)

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2. Igikorwa cyibinyabuzima no gutandukanya metabolike

Ibiranga D-mannose L-mannose

Kubaho Kamere present Kugaragara cyane muri kamere (mu mbuto, ibimera, glycoproteine) ? Kubaho bidasanzwe (synthesis ya laboratoire)

Igikorwa cyibinyabuzima ? Ifite ibikorwa byingenzi byibinyabuzima ?? Nta gikorwa cyibinyabuzima kizwi (ntigishobora guhindurwa no gukoreshwa numubiri wumuntu)

Inzira ya metabolike irashobora kuba fosifora na mannose kinase (MK) kandi ntishobora kumenyekana na enzymes ya metabolike yabantu (enzymes zifite chiral yihariye)

Imikorere ya physiologique irimo synthesis ya glycoprotein, kwirinda UTI, kuvura CDG, nibindi

Hafi yingaruka ziterwa nisukari yamaraso (kubera kutinjira / metabolised)

Kuki D-ubwoko bwonyine bwibinyabuzima bukora? ?

Enzymes hamwe nabatwara ibinyabuzima bifite umwihariko wa chiral (stereoselectivite):

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Kumenyekanisha imisemburo ya metabolike:

Mannose kinase (MK) mu mwijima wabantu imenya gusa na fosifori D-mannose kandi ntishobora gukora kuri L-isomer.

Abatwara umwihariko:

Abatwara glucose yo munda (nka GLUT5) bahitamo gutwara D-mannose (nubwo ifite ubushobozi buke), mugihe L-mannose idashobora kwinjizwa neza.

Guhuza reseptor:

Intego nka reseptor ya mannose (MRC1) na bagiteri FimH adhesine ihuza cyane na D-mannose cyangwa ibiyikomokaho (nka D-mannoside).

4. Ibishoboka byo gukoresha L-mannose

Nubwo idafite ibikorwa byibinyabuzima, L-mannose ifite agaciro kihariye mubushakashatsi bwa siyansi ninganda

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Ubushakashatsi bwibinyabuzima:

Nibintu bifatika kuri D-mannose, ikoreshwa mukwiga uburyo bwo kumenya chiral ya enzymes.

Guhuza imiti ihuza:

Ikoreshwa muguhuza isukari idasanzwe cyangwa molekile ya chiral.

Igishushanyo mbonera:

Birashobora kuba nkibibuza guhatanira imisemburo yihariye (bisaba kwemeza intego).

Ibikoresho byihariye:

Ikoreshwa mugutegura chiral polymers cyangwa nanomateriali (nka sensor ya chiral).

Incamake y'ingenzi

Kugereranya ibipimo D-mannose L-mannose

Imiterere yimiti ya isomers yiburyo ibaho muri kamere, ikozwe muburyo bwa artile isomers ibumoso

Metabolism ya biologiya ? Irashobora guhindurwa na enzymes zabantu not Ntishobora kumenyekana na enzymes zabantu

Imikorere ya physiologiya glycosylation, kurwanya kwandura, kuvura indwara zidasanzwe ntayo

Gukoresha imiti yagaciro (gukumira UTI, kuvura CDG), ubushakashatsi bwintungamubiri zubushakashatsi, imiti ihuza imiti

Igipimo kinini gishobora gutera impiswi (ariko muri rusange umutekano), ntabwo ari uburozi ariko ntibishoboka

Kwibuka byoroshye:

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D-ubwoko = "ubwoko bwibinyabuzima bukora": ibaho muri kamere, irashobora guhindagurika, kandi ifite ibikorwa bifatika.

L.

Ijambo 'mannose' rivugwa mubijyanye n'ubuvuzi n'imirire bivuga D-mannose. L-mannose ntabwo ifite agaciro gakoreshwa mubuvuzi, ariko nkigikoresho cyimiti, ifite ubushobozi bwubushakashatsi.