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Kuki mannitol ikora kuburwayi bwinkari
2025-03-13
- Mannose (cyangwa D-Mannose) ni isukari yoroshye, ariko bitandukanye na glucose, mannose ntishobora kwinjizwa mu buryo bworoshye n'umubiri nyuma yo kurya, kandi 90% ya mannose isohoka mu buryo butaziguye binyuze mu nkari nyuma y'iminota 30 kugeza kuri 60 nyuma yo kuyifata, bityo rero nka glucose, mannose ntabwo igira ingaruka ku isukari mu maraso, ahubwo yibanda cyane mu nkari. Mannose irashobora kubangamira metabolisme ya glucose, ikabuza amavuta, kugenga ibimera byo munda no kugira uruhare mukurinda indwara. Gusobanukirwa byimazeyo uburyo bwibikorwa bya mannose mukuvura indwara zifitanye isano nurufunguzo rwo kwagura imiti.Mu myaka yashize, habaye ubushakashatsi bwinshi kuri mannose. Uyu munsi, tuzaganira niba mannose igira ingaruka mukuvura indwara zanduza inkari. Indwara yinkari nindwara iterwa no kwandura bagiteri mubice byose byumuhanda winkari, harimo impyiko, ureteri, uruhago, urethra, nibindi, ariko kwandura kwinkari byiganjemo uruhago na urethra. Kubera itandukaniro ry'umubiri hagati y'abagabo n'abagore, abagore bafite amahirwe menshi yo kwandura inkari kurusha abagabo. Ubushakashatsi bwerekana ko abagore bafite amahirwe angana na 50 ku ijana yo kwandura inkari mu buzima bwabo, kandi hagati ya kimwe cya gatatu nigice cy’abanduye bazandura mu gihe cyumwaka.Kuva mu myaka ya za 1980, mannose yakoreshejwe n'abaganga b'imiti ikora mu kuvura indwara zanduza inkari. Mu myaka yashize, hamwe nibimenyetso byinshi byubushakashatsi byerekana ingaruka zo kuvura no kwirinda indwara ya mannose, uruhare rwa mannose mu kuvura indwara zanduza inkari rwagiye rukurura buhoro buhoro ubuvuzi rusange.
Nigute mannose ikora?Iyo umuntu asohotse mu mpyiko, mu ruhago, no muri urethra, mannose izaba ikingiye ingirabuzimafatizo zinyura hamwe na bagiteri zigerageza kwizirika ku ngirabuzimafatizo, bigatuma bagiteri idashobora kwizirika ku ruhago no mu miyoboro y'inkari, ikabuza inzira kwandura bagiteri, na bagiteri zidashobora kwizirika ku mitsi y'inkari zizakurikira inkari hanze y'umubiri. Indwara nyinshi zanduza inkari ziterwa na uropathogenic Escherichia coli (UPEC). UPEC ihuza mannose hejuru ya selile epithelial selile ikoresheje proteine ??ya FimH kandi ntabwo yogejwe ninkari. Bahinduye mannose kugirango babone mannoside (M4284). Kuba ifitanye isano na poroteyine ya FimH yikubye inshuro 100.000 ugereranije na mannose, ariko ntabwo ifata hejuru y’uruhago kandi irashobora gusohoka hamwe na E. coli mu nkari.Mu bushakashatsi mpuzamahanga bwakozwe mu mwaka wa 2016, abarwayi bafashe mannose mu gihe cy’iminsi 13 bagabanutse cyane ku bimenyetso ndetse n’iterambere ry’imibereho yabo nkuko byasuzumwe n’ibibazo. Kugira ngo hirindwe kwandura indwara z’inkari, abashakashatsi bagabanije abarwayi mu matsinda abiri, itsinda ryita ku bantu ryakomeje gufata mannose, itsinda rishinzwe kugenzura ntacyo ryagize. Ibisubizo by'itsinda rya mannose, 4.5 ku ijana gusa byo kugaruka mu mezi atandatu, ugereranije na 33.3 ku ijana by'itsinda rishinzwe kugenzura. Abashakashatsi banzuye ko mannose ishobora gufasha mu kuvura indwara zandurira mu nkari kandi ko zishobora gukumira indwara zanduza inkari.