Umusemburo beta-glucan ni polysaccharide ikora ikomoka kurukuta rw'utugingo ngengabuzima. Mu 1941, Dr. Pillemer yavumbuye ikintu mu rukuta rw'umusemburo wongera ubudahangarwa. Mu 1961, Riggi yerekanye iki kintu gikora mu musemburo glycan nka beta-glucan [1]. Inkomoko rusange ya beta-glucan nayo irimo oats, fungi, ibyatsi byo mu nyanja, nibindi, kubera ko umubiri udashobora guhuza cyangwa gusohora beta-glucan ubwayo, igomba kongerwaho nisi.

Usibye urukuta rw'utugingo ngengabuzima twa glucan n'umusemburo hari na mannose ikabura amazi hamwe na chitine nkeya, β-glucan yari ifite 30% kugeza kuri 60% by'uburemere bwumye bw'urukuta rw'akagari, mu gice cy'imbere cy'urukuta rw'akagari, ni iy'imiterere ya polysaccharide, imikorere nyamukuru ya physiologique ni ukugumana imbaraga za mikoranike y'urukuta rw'akagari. Misaki n'abandi. wasanze imiterere yumusemburo β-glucan igizwe ahanini na β-1, 3-ihuza, kandi ikubiyemo igipimo runaka cya β-1, ibisigisigi 6.

Immunomodulatory efficacy yumusemburo beta-glucan biterwa nintego zayo neza, ubushobozi bwayo bwo guhuza reseptors yihariye hejuru yingirabuzimafatizo, mugihe byongera ibikorwa bya fagocytose ya macrophage. Ubu buryo bwihutisha uburyo bwo gukingira umubiri kandi bugakomeza kuringaniza sisitemu yumubiri.

Beta-glucan ikora cyane cyane ihuza ubwoko butatu bwa beta-glucan reseptor [4]: ??(1) reseptor ya Dectin-1; (2) CR3; (3) Abandi bakira, harimo reseptor ya scavenger na LacCer. Iyo umusemburo β-glucan winjiye mu mubiri w'umuntu ugahuza na reseptor, bizongera fosifora yo mu bwoko bwa immun reseptor immun reseptor tyrosine motif (ITAM) na Syk, kandi ikore inzira ya PI3K / Akt, amaherezo iganisha kuri fagocytose, urupfu rwa mikorobe ndetse no kurekura virusi z’amahanga. Hanyuma ukabona ingaruka zubudahangarwa.

Inyungu zubuzima bwuruhu rwa beta-glucan zigaragarira cyane cyane mubice bikurikira [6]:

1) Ubushobozi bwa Antioxydeant: β-glucan ifite antioxydeant, ishobora kubuza kubyara superoxide nandi moko ya ogisijeni ikora (ROS) kandi bikagabanya kwangirika kwingutu ya okiside kuruhu.

) Byongeye kandi, ikora firime ikingira hejuru yuruhu, ifasha kugumana ubushuhe nubwitonzi muruhu.

3) Gusana uruhu nubushobozi bwo gukiza: Seo nibindi. yasanze amasoko atandukanye ya beta-glucan ashobora guteza imbere kwimuka kwa keratinocytes yumuntu (HaCaT) hamwe na fibroblast yuruhu rwabantu (HDFa), kandi byihutisha gufunga ibikomere no kongera kwandura muburyo bwimbeba [7]. Byongeye kandi, anti-inflammatory na anti-irritant ya beta-glucan ifasha kugabanya uburibwe no gutukura no koroshya uruhu rwarakaye. Ubushakashatsi bwakozwe mu kinyamakuru cya Therapeutic Dermatology bwerekanye ko beta-glucan ari umugereka mwiza wo kuvura dermatite yoroheje ya atopic (eczema) [8].

4) Ingaruka zo kurwanya gusaza: Beta-glucan ifasha kugabanya ibimenyetso byo gusaza kwuruhu, nkiminkanyari no kugabanuka. Itezimbere synthesis ya kolagen nibindi bikoresho byuruhu bidasanzwe (ECM), byongera umubyimba nubworoherane bwuruhu.

Byongeye kandi, beta-glucan ifite kandi uruhare rwo kugenzura ibimera byo mu mara, kugabanya cholesterol, kurwanya umunaniro, ubuzima bwamagufwa nibindi.

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