Mu rwego rwubushakashatsi bwubuzima bwo munda, Polydextrose imaze igihe ishyirwa mubikorwa nkibisanzwe byamazi meza. Nyamara, ubushakashatsi butandukanye bwakozwe mu myaka yashize bwerekanye ko iyi molekile ya sintetike itunganijwe neza iturutse kuri glucose mu byukuri ni "umukinyi uhinduranya" ushobora kuba mikorobe yo mu mara ikoresheje uburyo butatu bwo "kugenzura ibinyabuzima byangiza - kugaburira neza microbiota - metabolite cascade reaction". Ubushakashatsi buheruka gukorwa muri Nature Gastroenterology mu 2024 bwerekana ko gufata buri munsi 10-15g ya polyglucose bishobora kongera ubusugire bwinzitizi yo munda ku gipimo cya 37% kandi bikagabanya urwego rwibintu bitera IL-6 kuri 29%. Ubu buvumbuzi ntibuhindura gusa ubumenyi bwa gakondo ahubwo butera no guhuza imipaka itandukanye kuva mu nganda y'ibiribwa kugeza ku buvuzi.

?

Youdaoplaceholder0 Igice cya 1 Kumenyekanisha Ubumenyi: "Inzira Yigifu Yuzuye Ubwenge" ya molekile ?

Youdaoplaceholder0 1.1 Guhindura Viscosity: "Igisubizo cyubwenge" kuva mu gifu kugera munda ?

Umwihariko wa polydextrose uri muburyo bwa Ph-yitabira guhinduka kwijimye:

?

Youdaoplaceholder0 Inda ? (pH 1.5-3.0): Iminyururu ya molekulari ihujwe binyuze mumigozi ya hydrogène kugirango ibe imiterere y'urusobekerane rw'imiyoboro itatu, isabune ya viscosity igera kuri mPa · s 1500, igabanya umuvuduko wa gastrica kugera kuri 45% (ugereranije na 20% gusa ya fibre isanzwe y'ibiryo), byongera cyane guhaga;

Youdaoplaceholder0 Amara mato ? (pH 6.0-7.4): Imigozi ya hydrogène yacitse igice, viscosity igabanuka kugera kuri mPa · s 400, kandi aside aside ya adsorption igabanya kwinjiza cholesterol kuri 18% bitagize ingaruka ku kwinjiza intungamubiri;

Youdaoplaceholder0 Colon ? (pH 7.0-7.5): Fermentation ya mikorobe iratangizwa, viscosity igabanuka kugeza munsi ya mPa · s 50, aside irike ya fatty acide (SCFAs) irekurwa, hamwe na acide ya butyric yiyongereyeho inshuro 3.2, igahindura mu buryo butaziguye gusana ingirabuzimafatizo zo mu nda (Ishusho 1).

Youdaoplaceholder0 Ikoranabuhanga rya Breakthrough ?: Ikoranabuhanga rya DSM rya SmartVisc ? rishobora gutegekanya umurongo wijimye wibice bitandukanye muguhuza urwego rwa polymerisiyonike (agaciro ka DP), nka formula yo mu bwoko bwa G yagenewe cyane cyane abarwayi bafite gastroesophageal reflux, ikora firime ikingira umubiri hamwe na visa igera kuri 2000 mPa · s munda.

?

Youdaoplaceholder0 1.2 Amabwiriza ya Microbiota: Kuva "kugaburira ibintu byinshi" kugeza "inyungu zigamije" ?

Indwara ya prebiotics gakondo itera mikorobe zose zitavangura, mugihe polydextrose yerekana ubushobozi bwukuri bwo kugenzura:

?

Youdaoplaceholder0 Upstream inhibition ?: Imiterere yubukonje bwinshi ikora inzitizi yumubiri mumyanya ndangagitsina yegeranye, ikabuza gufatira kwa bagiteri zitera indwara (nka Escherichia coli), bikagabanya umuvuduko wa koloni ya 52%;

Youdaoplaceholder0 Ikwirakwizwa rya Downstream ?: Ibice bya Oligosaccharide byakoreshejwe cyane na bagiteri zifite akamaro nka Bifidobacterium na Roseella, kandi ubwinshi bwazo bwiyongereyeho 68% nyuma yibyumweru 8 byitabiriwe (bishingiye ku buryo bwa metagenomic);

Youdaoplaceholder0 Metabolic synergy ?: Acide Butyric yakozwe ikora reseptor ya GPR109A, itera itandukanyirizo rya selile T, kandi igahindura igipimo cyerekana ubudahangarwa bw'umubiri bugera kuri 0.91 (urwego rwubuzima> 0.85).

Youdaoplaceholder0 Igice cya 2 Umuyaga wo gusaba: Imyitozo yambukiranya imipaka kuva kumeza kugeza kuryama mubitaro ?

Youdaoplaceholder0 2.1 Inganda zibiribwa: "Moteri itagaragara" hamwe nimirimo yazamuye ?

Youdaoplaceholder0 Baking Revolution ?: Itsinda rya Meiji ryu Buyapani ryateje kuki zeru-sucrose hifashishijwe ubushobozi bwo gufata amazi (8.3g amazi / g) hamwe nubushyuhe bwumuriro (kwihanganira 220 ° C) ya polyglucose, bigabanya ihindagurika ryamaraso ya glucose nyuma ya 41%.

Youdaoplaceholder0 Ibinyobwa bishya ?: Amazi meza ya Nongfu Isoko y'amazi, akoresha umutungo wa gazi ya fermentation ya gaz ya polyglucose kugirango agabanye igifu nta kurakara, yagurishije amacupa arenga miliyoni 8 mukwezi kwayo kwambere ku isoko;

Youdaoplaceholder0 Amafunguro yo gusimbuza amafunguro ?: Soylent muri Reta zunzubumwe zamerika ikoresha formula ya viscosity-gradient kugirango yongere ingufu zitinda kurekura amasaha 6 kandi bitezimbere kwihangana kwabiruka muri marato 23%.

Youdaoplaceholder0 2.2 Imirire yubuvuzi: "Inzitizi yo mu nda" kubarwayi ba ICU ?

Ubushakashatsi bwa RCT bwibitaro bya Sir Run Run Shaw, Ishuri ryubuvuzi, kaminuza ya Zhejiang (n = 204) byerekana ko:

?

Youdaoplaceholder0 Kwirinda kwandura ?: Mu barwayi ba ICU hiyongereyeho 15g ya polydextrose buri munsi, indwara ya septis ya enterogenous yagabanutseho 44%;

Youdaoplaceholder0 Gusana Mucosal ?: Plasma ligonin (ikimenyetso cyerekana ko amara yinjira) yagabanutseho 31% naho ubucucike bwakagari bwiyongereyeho 39%;

Youdaoplaceholder0 Immunomodulatory ?: Ubukorikori bwa Serum IgA bwiyongereyeho 28%, naho igipimo cya CD4 + / CD8 + T cyagarutse mubisanzwe.

Youdaoplaceholder0 Igice cya 3 Impinduramatwara ya Tekinoloji: Kuva Igishushanyo cya Molecular kugeza AI-Ifasha Imirire Yuzuye ?

Youdaoplaceholder0 3.1 Guhindura imiterere: Fungura Customisation kubisabwa ?

Youdaoplaceholder0 Targeted viscosity ?: Mugutangiza iminyururu yo kuruhande rwa sorbitol, hateguwe polyglucose yihariye yo mu bwoko bwa colonike (ubwoko bwa C), ubwiza bwayo bwaragabanutse cyane kugera kuri mPa · s 10 kuri pH 7.0, cyane cyane kubantu bafite igogora;

Youdaoplaceholder0 Umuco wazamuye ?: Roguet, mubufaransa, wateje imbere Probiocoat technology tekinoroji ya microcapsule ikubiyemo porotiyotike muri matrike ya polyglucose, byongera ubuzima bwa aside gastrica kuva kuri 15% ikagera kuri 92%.

Youdaoplaceholder0 3.2 UBWENGE BUKORESHEJWE: Kurenga kode yo gutabara kugiti cyawe ?

Sisitemu ya "Digital Twin of the Intestine" yubatswe na NutriAI, isosiyete yo muri Isiraheli, ihuza ibibazo 200.000 by’imiterere y’ibimera byo mu nda by’abantu hamwe n’amazi yerekana imbaraga, bishobora guhanura uko umuntu yakira polydextrose:

?

Youdaoplaceholder0 Dose optimizme ?: Gahunda ya 8-12g / kumunsi + fructooligosaccharide ihuza gahunda yasabwe kubarwayi ba IBS yagabanije kwandura inda 67%;

Youdaoplaceholder0 Scene ibereye ?: Imyitozo ngororamubiri yimbaraga nyinshi yagenewe abakinnyi, ibyo bikaba byongera igipimo cya fermentation ya colonike 40% kandi ikirinda ikibazo cya gastrointestinal mugihe cyo kwitoza.

Youdaoplaceholder0 \ n \ n Igice cya kane: Ihungabana ry’inganda: Ikoranabuhanga rirwanya isoko rya Trillion-dollar ?

Youdaoplaceholder0 4.1 Irushanwa ryubushobozi: Ibigo byabashinwa kurenga kumurongo ?

Youdaoplaceholder0 Baolingbao Bio ?: Shora miliyoni 800 yuan kugirango wubake umusaruro munini wa polyglucose ku isi, ikoranabuhanga rya synthesis enzymatique kugirango ugere kuri 99.9%;

Youdaoplaceholder0 Hualixi Biotech ?: Yateje imbere nano-fibrotic polyglucose, ibyiyumvo byo kugenzura ibibyimba byiyongereyeho inshuro 4, ibona ibyemezo by’ubuvuzi bidasanzwe bya NMPA;

Youdaoplaceholder0 Imiterere y’amahanga ?: DuPont ifatanya n’ivuriro rya Mayo kugira ngo bateze imbere icyiciro cya gatatu cy’amavuriro ya polydextrose mu rwego rwo kwirinda kanseri yibara.

Youdaoplaceholder0 4.2 Ibibazo byo kumenya: Icyuho kuva muri Laboratwari kugera ku isoko rusange ?

Nubwo ibimenyetso bya siyansi bihagije, ubushakashatsi bwabaguzi bwerekana ko:

?

Youdaoplaceholder0 Ubumenyi Impumyi Ikibanza ?: 31% byabaturage bonyine bumva itandukaniro ryimikorere hagati ya polydextrose na fibre isanzwe;

Youdaoplaceholder0 Dose imyumvire itari yo ?: 45% byabaguzi bibeshya ko "byinshi ari byiza", bishobora gutera ibibazo nko kubyimba;

Youdaoplaceholder0 Inganda Igisubizo ?: Sosiyete ishinzwe imirire mu Bushinwa yasohoye impapuro yera ku ikoreshwa rya Polydextrose, ishyiraho igipimo cyiza cya 15g kumunsi.

Youdaoplaceholder0 Igice cya 5 Icyerekezo kizaza: Kuvugurura Fibre ya 'Smart Boundary' ?

Youdaoplaceholder0 5.1 Ubwonko-Gut Axis Iterambere: Ikiraro cya molekulari kuva mu gituba kugera kumarangamutima ?

Ubushakashatsi buherutse gukorwa ku nyamaswa mu kigo cy’ikoranabuhanga cya Californiya bwabonye:

?

Youdaoplaceholder0 Kugabanya amaganya ?: Imbeba zo mu itsinda rya interineti rya polyglucose zongereye igihe cyo gukora ubushakashatsi mu kizamini cya maze ku kigero cya 53%;

Youdaoplaceholder0 Mechanism tracing ?: Acide Butyric ikora imvugo ya BDNF muri hippocampus ikoresheje inzitizi yubwonko bwamaraso, ikongera ubwinshi bwa synaptic kuri 29%.

Youdaoplaceholder0 5.2 Biologiya yubukorikori: 'Ultimate Form' ya fibre programmes ?

Isosiyete ya Ginkgo Bioworks muri Amerika yahinduye imisemburo ikoresheje ikoranabuhanga rya CRISPR-Cas9 kugira ngo isohore mu buryo butaziguye "polydextrose ya gene" ifite imirimo yihariye:

?

Youdaoplaceholder0 Intego igamije ?: Irashobora gushishikarira cyane gukura kwa Achaemenia, kandi ubwinshi bwayo bwiyongereyeho 80% muburyo bw'umubyibuho ukabije;

Youdaoplaceholder0 Igisubizo cyubwenge:

Youdaoplaceholder0 Umwanzuro: Iyo Intelligence Intelligence ihuye na Gut Ecology ?

Urugendo rwa siyanse rwa polydextrose ni amateka yo kugaruka kuva "ku nganda-nganda" kugeza kuri "injeniyeri yo mu nda". Iratubwira ko iterambere ryukuri mubuzima akenshi rituruka kumyubakire yimbitse no kuvugurura imipaka ihuza ingingo yibintu. Nkuko Jennifer Doudna wahawe igihembo cyitiriwe Nobel yabivuze, "Ibinyabuzima bya sintetike biratwigisha ko molekile zishobora guhabwa 'ubushobozi bwo gutekereza'." Muri iyi mpinduramatwara ya tekinoloji yubuzima bwo munda, polydextrose irashobora kuba intangiriro - mugihe "molekile zubwenge" nyinshi zinjiye kurugamba, ikiremwamuntu amaherezo kizagera kubikorwa byo kurwanya indwara zidakira.