1.1 ??? ??? ????????????? ??? ???????? ????? ?????? ??????? ?????

1956 ?? ?????? ????? ???????????? ?????? ??????????? ?????? ??? ????????? ??? ?? ??????, ??? ?????? ??????? ?????? ?????????? ?????? ????????? ??? ?????? ?????:

• 1980 ????:???????? ??? ??? ??? ??????????? ??????? ??? ????? ?????? ??.

• 2010 ????:?? ???????? ????? ??????? ???? ?? ???? ?? ???? ????? ??? (PET-CT ????? ???????? ?? ????? ????????? 23% ? ????????? ???????? ??? ???)

• 2024 ??,?????? ?????? NIH ?? "?????? ???? ???????????" ???? ??????? ?????? ??????????? ??? ?????????? ????.

1.2 ????? ???????? ?????? ??????

Evaluate Pharma ?? ???? ??? ????:

2024 ?? ????? ???????? ???????? ????? ?????? 4.7 ????? ??? ??? (CAGR 12.3%).

????? ?????? ??????? ??? ?????? ??? ????? ??? 400% ???? ??? ???? ????.

?????? ?????? ?? ??:

???? ??????????? (MMSE ????? 2.1 ???? ???? ?????? ???)

????? ???? ????? ????? (GOS ??????? ??????? ??????? 1.5 ???? ???? ???)

???? ?????????: ??????????? ??????????? ??? ??????? ????????

?

2.1 ???????? ??????? ?????

??????? ?????? ?????? ?????: ???????????????????? ????????? ?????? ??? ???????? ??????????? ???? ?????? I: ????????????? ??????????? ?????? ?????????? ??????????? ???? ?????? ???? ?????? IIA: ?????????? ???????? ???????? ??????? ???????? ?????? ????????? ???? ?????? ???? (????????? 18% ???? ???? ???) ?????? IIB

?

2.2 ?????? ???????? ????? ????

??? ????-???? ????? ?????????? ???? ??????? ???? ?????? 2024 ?? ??? ?? ???????????? ???? ?? ?????:

???????? ???????? ??? 6?? ????? 1000mg ????????? ?????? ????? ????? ??????? ???????????? ???????? ?????????? 7.2?? ????? ????? ?? ?? ???.3

???? ?????, ???????? ??? 72 ?????? ??? ?????????? ?????? ?????? ???? ?????? ???????? (p=0.34).

?????? ?????????: ??????? ?????

?

3.1 ????????? ?????? ??????

UK NICE ??????????: ?????? ????? ????? ???? ???? ???? ????? ?????? ?????????? ???? ?? ????? (???????-???????? ??????? ￡45,000/QALY)

???????? ?????? ???????? **2025 ???? ?????????: ???? ?????? ???????? ??????? ???????? ????? ?????? ???? ?????? ????? (p=0.21)

3.2 ????? ??????????? ????? ???? ???????

????? ?????? ???????? ????????? 2024 ???????:

?????????? ?????? ?????? ???????????? ?????? ("????? ?????????" "??????????? ???? ??????" ??? ?????????? ?????)

??? ????????? ???????? ???????? ???? ??? ?? ???????????? ???? ????? ??? ????????? 32% ? ????? ????????? ????? ?? ??? ??????????? 70% ? ??? ??? ????.

????? ?????????: ???????? ????? ???? ??????

?

4.1 ?? ??? ???? ?????? ???????

???????? ????? ??? ?? ??????? ??????? ???? ?????-????? ????? (????? ????? ???????? ???????? ??????? ????????, CN202410123456.7)

?????????????? ??????-?????? ???????? ?????? (????? ???????? ???? ????? ????? ?????????? ???? ?????? ?????? ????? ??? ??????????? ???? ????? ????????? ???????? ????)

?

4.2 ???????????? ????? ????

?????? ??????? ??????????? ??????? ?????:

CDP-????????????? ??? ??????? ??????? (??????? ????????? 31% ?? ??? ??) ??? ????? 47% ???? ???? ?? ??.

????? ????????? ???????? ???? ??? ????

?

5.1 ?????????? ???

????? ?? ??????? ???????? ?????????: ??????? ????????? ????? ???, ???????? ???????? ????? 62 ???????? ?????????? ???????? ????? ??????? ????? ??????? 32% ??? 89% ????? ??? ???????? ??? ???.

5.2 ????? ???? ???????? ????? ????????

"?????? ??? ?????? ?? ????????, ?????? 300 ? ????? ????? ??? ??????????? ????? ??? ????" - ??????? ???????? ?? ???? ?? ??? ?????? ??????? ?????????.