?????, ???????? ?????? ?? ?????? ??? ?????????? ??????????

???????? ?? ??????? ?????????? ??????????? ???, ???????? ???? ???? ???? ???? ??????????? (????????????) ????????? ?? ????????? ???????? HMB-Ca ???????? ????????? ???????? ?? ??. ?????? ???? ?????? ?????? ??? ??????? 65 ? ???? ???????? ?????????? ????? HMB-Ca ??????? 3 ?? ??????? ??? ??? ????, ???????? ?????????? ??????? ??? ???????? ??? 12 ?? ???, ??? ?? ?? ???????? ???? ???? ??????? ??????????? 1.2 ???? ???? ?? ????, ?????? ?????? 14% ???? ???? ?? ????, ????? ???? ?????????? ?????? ??????? 23% 34 ????? ??? ?? ?????. ??? ??????????? ??????????? ?????? ?????:

?

mTOR ?????? ??????? ?????: ???? ???? ????????? ???????? ???????????? 38% ???? ???? ?????.

? ??????? ??? ?? ???????????? ??????????? ???????: ???? ???? ????????? ?????? (MuRF1 ????) ????????? 41% ???? ??? ????.

??????? ??????????? ??????? ????: ???? ??????? ????? ?? IL-6 ????? 29% ???? ??? ??? ??? ??????? ??????? ???? ?????? ????.

?????? ??? ?????????? ????????????, ??????? D3 ??? ???????? HMB-Ca ?? ??????????? ?????? ???????? ???????? ???? 17% ???? ??? ?? ??? ??? ???? ??? ?? ??????? ??????? ?? ????????? (SASP) ?????? 34% ???? ??? ????. ????????? ????? ???????? ???????? ????? ???? ?????? ????? ????????? ?????? ??????? ??????????? HMB-Ca ?? ???? ????? ?????? ?????? ??????? ?????? ???, ????? ???? ????? ?????? ?????????????? ????? ?? 19% ? ????????? ???????? ????.

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2. ?????? ???? ????? ????????? ????????

????? ?? ??????? ??????? ??? ???? ????????? ???????? HMB-Ca ??????? ??????? ??? ????????? ????:

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?????? ?????????? ?????????: ??? ??????? ?????? ??? ?????? ???? ?????-3 ??? ???? ??? HMB-Ca ??????? 3 ?? ????????????? ??? ??????? ??? ?????? ?????? ?? ??? ??? 62% ???? ??? ?? ???? ??? ??????? ???????? ????? 38% ???? ???? ?? ?????.

?????????? ??????????? ????: ???? ?????? ?????????? ?????????? 30% ?? HMB-Ca ????? ??????? ???? ?????? ?????? ????, ????? ??? ?????? ???? ??? 5-7 ???? ???? ?? ??? ????????? ????????? ??????? 41% ???? ??? ??.

????? ??????????? ?????: COPD ?????? ??? HMB-Ca ?? ???? ??? ?????? ???? ???????? ?????? ?????, ??? 6 ?? ???, ???????? 6 ? ??????? ??? ????? 82 ???? ???? ???, ????? ???? ?????? ?????? 21% ???? ???? ???.

?????? ???? ???? ??????????? ????????? ???? "???? ??????" ??? ?????? ???? FDA ?????? HMB-Ca ????? ?? ??? ???, III ????? ?????? ???? ????? ??? ???? ???????????????? ????? 28% ???? ?????????? ?? ??? ???? ???????? ???????????? ??????????? 19% ???? ??????? ?? ??? ???? ?????? ?? ??.

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3. ?????????? ??? ?????????? ????? ?????

????????????? ?????????? ??????? ???????? HMB-Ca ?? ?? ????????? ???????? ?? ??:

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??????????? ?????????: ??? 12 ?? ???? HMB-Ca ??? ??????? ??? ???? ???? ?????? ????????? ?????? ???, HOMA-IR ?????? 23% ???? ??? ?? ??? ????? ???? ???? ???????? ???????? 37% ???? ???? ???.

??? ?????????? ??????????????: AMPK ?????? ??????? ???????? ??????? ???????????????? ???????? 29% ???? ??? ?? ??? ????????????? ????? 18% ???? ???? ???.

?????? ??????????? ???????: ???? ??? ??? ???? ????????? 42% ???? ???? ?? ??? ??????????? / ?????????? ???????? ???????? ??? ?????? ???? ???????????????? ????? 31% ???? ???? ?????? ???.

???????? ???? ??? ????? ??? ???? ????????? ????????, ????????? ??? ???????? HMB-Ca ??????????? ?????? ????? ???????????? ????? ??????? 1.2 ???? ??? ?? ??? ALT ?????????? ??????? 68%57 ????? ???? ????. ?????????? ??????????? ??? ??????? RCT ???????????? ??? 24 ? ????????????? ??? ??? ?????? ???????? ??????? ????? (ASCVD) 19% ???? ???????? ???????? ????.

?

4. ????? ?????? ?????? ???? ???? ??????????

HMB-Ca ?? ????? ?? ????? ?????? ???????? ?????? ?????? ???? ?? ?????? ???? ??????? ????:

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??????????? ??? ????????????: ????? ???????????? ?????? ???, ??????????? ??? 3 ?? ??? ????? HMB-Ca ??????? 6 ?? ??????? ??? ?????? ??????? ????????? ???? ???? ?????? ??? ???????? ??? ?????? ???? 2.3 ???????? ???? ?????? ?? ???? ??? ????? ?? ???? ???? ??? 2.5 ???? ???? ?? ?????.

???????? ?????? ?????? ???????: ??? ?? ?????? ?????? ???????? ?????? ???? HMB-Ca ????? ??? ???? ??????? ????? ???????? ???????? ?????? 41% ???? ??? ?? ??? ?? ???? 57% ???? ???? ?????? ??? ???.

???? ???? ?????????? ???? ????: ?????? ???? ???????? HMB-Ca (50mg/kg/d) ??????? ???? ?? ?????? 24% ???? ?? ?????? ??????? ????? 19% ???? ???? ????.

????? ????? ?????? ?????? HMB-Ca ????? ?????? ?????? ???? ?? ?????? ???? ??????????? ????????? ?????? ?? ??? ???, ?????? ???????? ???? ??????? ?? ?????????? ??????? ???????? ???? ??????? 8 ????? ???????? ????? 6 ? ??? ????? ????? ?? ??. ?????? ???????? ??? ?? HMB-Ca ??????-?????? ???????? ??? ????????? ?????? ?????? ??????? 91% ????? ???? ?? ???? ??? ????? ??? ??????????? ???????? ????? ±7% ????? ??? ?? ?????.

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5. ??????? ??????????? ?????? ???????? ???? ?????

????????????? ??????? ???? ???????????? ?????, ??????????? ?????? ????????? HMB-Ca ?????? ?????? ?????? ??:

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?????? ????? ????????????: ???? ?? ???? ????? ??? ?????? ???, HMB-Ca ?? ??????????? ????????? ???????? ??????? ???????? ????? ???? ???? ???????? ?????? ???????? 17% ???? ?? ??? 6 ?? ??? ADL ????? 23% ???? ???? ???.

??????? ????????????? ???? ?????: ??????? ???????? ????? ????????????????? ???, HMB-Ca ???????, ?????????????? ???? ???? ????? 58% ???? ??? ?????, ??? 3-4 ?? ??? ?????????? ???? ???????

????????? ?????? ????????? ??????: ?????????? ????????? ???????????? ????? ?????????? ????? HMB-Ca ??????? 3 ?????? ??? ?????? ???????? ????????????????? ???? ???? ????? ??? 72% ???? ?? ????? ?????? ??? ???? ??????? 39% ???? ??? ???.

??????? ????? ?????? ??????????, HMB-Ca ????? ???????? ?????? ????? ?????????????? ???????????? ??? ????? ??????????? ??????? 44% ???? ?? ??????? ?? ???? ???? ??????? ???????? 51% ???? ??? ??? ???. ??? ?????????????? ???? ????????? ??? 2 ?? ??? HMB-Ca ?????? ??????? ????? ???????? ????? ????? ??????? ?????? 37% ???? ??? ?? ???? ?? ??????????? ??????? ?????? ????? ??????? ????.

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6.????? ?????: ??? ??????? ??????????? ?? ??????????

HMB-Ca ?? ?????? ???? ????? ?? ????????? ???????? ???? ????:

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???? ?????????? ???????: ????????? ??????????? ?? ??? HMB-Ca ???????? ???? ????? ???? ???? ??? ?? ??????? 3.7 ???????? ???? ??? ??? ?????? ???? ??? 72 ????? ????? ????.

???????? ??? ??????? ??????: HMB-Ca ?? ??????? 62% ???? ??? ??? ???, HMB-CA ?? ??????????? 99.9% ??? ????????? ?????????? ??? ???.

??????? ???? ??????????: ?????? ???? ???????? ??????? ?? ?? HMB-Ca ???????? ??????-?????? ????, ????? ????? EMG ???? ???? ?????? ???????? ????? ??????.

??? ??????? ???????? ????? HMB ?????????? ?????? ??????? ?????? ???? ?? ???, CRISPR-Cas9-??????? ?? HMB ???????? ???? ??? ??????? ????? ???????? ????? ??????? ???? ???? ???????? 29% ? ????????? ????????? ???????. ??? ???? HMB-Ca ??????????? ?????? ?????? ?????? ?????? ????? ??? ???, ??? ??? ????????? ????????????? ??????? ??????? ??? 2.8 ???????? ???? ?.

??????? ?? ?????? ????????

HMB-Ca ?????? ?????? ?????????? ???????? ???, ?? ????? ????? ????? ?????? ??:

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???????? ?????: ???? ????? ?????? ????? ??????? 5 ???????? ??? ??????? ????, ???? ???????????? ???? ????????? ??????????? ??? ??? ???.

??? ?????????????: ???? ???? ??? 2-3 ?????? ????? ??????? ???? ??? ???, ??????? ????? ?????????? ???????? ???????? ?????? ????? ?????.

?????????????: ??????????????? ??? ???????????? ??? ?????? mTOR ????? ??????? ????? ???? ??? ?????.

?????????? ??????? ???? ????? (ISSN) ??????? ??? ?? ??????? ????, ??? 2-3 ?? ???? HMB-Ca ??????? ???????? ???????? ??? ??? ??? ?????? ???????? ????? ??????? 1-2 ????? ???? ?? ?????. ?????? ?????? ?????? ??????? ????? ???, HMB-Ca ???? ???????? ??? ???-???? ??????????? ??????????? ??????????? ????? ??????? ?????? ????? ???, ??? ??? ????? ????? ?????? ?????? ????.