1、 ????? ??????????

??????? ?????????? ?????????? ?????????????

??? ?????????? ??????????, ???? ???? ???????? ??? ?????????????? ????????? ??? ???? ???, ?? ???? ?????????? ????? ???? ?????????, ?????????????? ????????? ?????? ????, ?? ???? ??? ??? DNA ?????????? (TET2) ??????????????? ??????? ???????? ?????????? ????? ???? ?????????? ?????? ??????? ?????? ??.

??????? C TET2 ??????? ??????????????? ??????? ????.

TET2 ?? ????????? ??????????? ??? ??????? C, ???? ???????????? ?????? ?????????????? ?? ???????? ?????? ?????????? ????????, DNA ??????????? ??????????????? ??? ?????? ??? ?????? ?? ?????????????? ?????? ??????? ???? ????? ?????? ?????.

?????????? ?? "?????? ????" ???? ?????? ????????? ?????

?????????????? ????? ?????????? ?? ?????-?????? ?????????? ??????? ????, ?????????? ????????? ?????? ???? ?????????? ?????. ??????? C ?????????? ??? ??????? ???????? ??? ?????????? ????????? ??? ????? ???? ??? ?????????? ?? ?????? ???? ??? ??? ?? ?????.

2, ???????????? ??????

???? ????? ?????????: ????? ????? ??????? ??, ??????? C ?? ?????????? ?????? ???????? ??????? 60% ???? ???? ?? ???, ??? ?? ?????????? ?? 80% ???? ??? ?? ???, ???? ??????? ???? ????? 50% ???? ??? ????.

?????? ?????: ??????? C ???????????? (IFN) ???? ?????? ???? ?????? ????, ???-?????????? ?????????? ???? ?????? ?????????????? ????? ??????? ???????? ????, ?? STAT1 ??????????????? ???????, ?????? ?????? ?????????????? ?????????? ???? ????.

3、 ?????? ?????? ?????

??? ??????????? ?????????? ?? ?????: ??? ???? ?????? ????? ???????????? ?? ???????????????? ???? ???? ???? ???-?????????? ?????????? ????? ????, ????????? ?????????? ????? ?? ?????????? ?????????? ??? ?????? ????, ?????????? ???? ????? ?? ???????????? ?????.

??? ?? ????????? ???????: ??????? ?? ??? ?????? ?????? ????????? ??? ??????? C, ??? ???????? ??? ?????? ?? ????? ???? ??? ?????? ????? ?????????? ??? ???????? ?????? ?? ?????.

?????????? ?????? ???: ???????? ???? (??????? C ????) ?????????? ??? ??? ?????, ?????? ??????????? ??????????? ?????? ???????? ??? ?????????? ??? ??????????? ???? ?????? ?????? ??? ?? ?????.

4, ????? ??????? ???????

???? ???????? ?? ?????????? ???? ??????? ?????????? ??? ??????? C ?? ?????? ?????? ?? ???????? ??????? ?????? ?????? ?????.

???-?????????? ?????????? ????? ??????? ?????? ????????? ??????? C ???????? ????? ??????? ?????.

????????????? ?????-TET2 ????? ????? ?? ??????? ?? ??????????????? ??? ???????? ?????.