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??? ???, ?????????? ???? ????? ??????? ???? ???? ??? ??????? ?? ???? ???? in vitro ?????? ??????, ?? ????? ?? ???? in vitro ????? ????, ??????? ???? ???? ??????? ??????? ????-?????????? ??????? ??? ??? ?????? ???? ??? ??? ?? ??? ???, ?????? ??? ?????????? ?????? ???????? ????.
??????, ??????? ????? ????? ?????????? ??????????? ?????? "??? ?? ??????? ????????? ????? ????? ?????? ??? ????? ?? ??????? ?????????? ???? ???????? ?????? ??? ????? ??? ??? ???? ?? ?????? ???? ???? ?????? ????" ?? ?????? ????? ???? ?????? ??????????? ????????? ??? ??? ???.
???????????? ???? ?? ????? ?????? ??????? ???? ?????? ???????? ??????? ??? ???? ?? ?????? ??? ???? ????? ?? ???? ????, ????? ??? ?? ???? ??? ???? ????? ???????, ???????????? ?? ?????? ???? ?????? ?????? ????, ???? ???? ????????? ???? ?????? ?? ???? ?????.
??? ????????? ??, ?????????? ????? ????? ???? ?????? ??????? ????? (HK) ?????? ??? ?????????? ??????? ????????? ???, ?????? ????? ???? HK ??? ?????????? ???? ????????, ?? ????? ??????? ???????? ??? ??????? ??? ????? ??? ????, ??????? ???????, ????????????, ????? ???????? ?? ??????? ????? ?????? ?? ????????? ???????? ????????? ???.
????????? ??? 20 ?? ?????? ?????? HK ????? ????? ??? ??? ???? ??? ????? ??? ?? ????? ?????? ?? ??? ?????.
????????????? ???? ???? HK ????????? ???????? ??????? ???????? ??? ???? ??? 32.25 ?? ?? ??? ???? ???????? ??????? ???????? ??? ???? ??? 28 ?? ????? ????. HK ?????????? ??? ???? ??? 4.25 ???? ????? ?? ??? ?????? ?? ?????? ????? ????????? ??? ???? ?????? ???? ??? ????? ???.
??????? ??, ??????, ?????? ?? ?????? ?? ??????????? ???????????? ???? ???? HK ?????????? ??????? ????????? ?? ???? ??? ?????? ???????? ??? ???? ????, HK ?????????? ??????? ?????.
?? ?????, HK ?????????? ????? ?????????, ?????? ?????? ?? ???? ???? ??????? ????? ???? ???? ?? ???? ??? ????? ??? ?????? ???? ???????? ?????????? ???.
??? ????????????? ???? ????? HK ?????????? ????? ??????? ?????? ??? ???? ?? ??? ???? ????? ?? ???? ????, ?????? ??? ???? ???? ????? ??????? ?????.
??????? ????????????? ???? ???? HK ?????????? ????? ??????? ???????, ?????, ???? ???? ??????? ?? ?????? ??????????????? ????? ????? ??? ?? ?????? ???? ???????? ?????????? ?? ????.
????????? ???????????? ???????? ??? HK ?????????? SAUL_SEN_MAYO ?????? ??? ?????? ?????? ???? ??? ??? ??? ????, ??? ??????? ??? ?? ?????? ??? ?????? ???????, ?????????????? ??????? ????? ?? ???? ??????? ??????? ???? ????????? ??? ??????? ?? ??? ????, ????? ???????? HK ?????????? ??????? ?? ???? ??? ?? ??????? ?????? ?????? ????? ?????????? ?? ????. ?? ?????, ???? ????, ??, ?????? ?? ?????? ????????? ???????? HK ?????????? ?????? ????? ????? ?????? ???? ?????? ?????? ??? ??? ?? ???? ????? ???.
????????? ???? ???? ?????, ?????????? ??????? ????? HK ?????????? ????? ??? ???????? ????? ?????? ??????? ??????? ???????? ??? ?????????????? ???? ????? ???? ??? ?? ??? ??? ??? ?????? ?? ???? ????.
????? ??????, HK ??? ????? ??? ????? ????? ?????? ?? ??????, ?????????? ?????? ??? ?????????? ??????????? ??? ??? ??????? ??????????? ????????? ?? ???, ????????????? ???? ???? ??????????? ???????? ?? ?????????? (Lut), P16 ?? CDK6 ??? ????????????? ????? ???????? ???? ??? ???? ?????? ??? HK ?????? ??? ?????????? ??????????? ???????????? ????.
??? ??? ??, ??????????? ??? ?? ??? ???? ??? ?????????? ??, ????, ?????????, ???? ???? ?????? ??????? ??? ?? ????? DNA ???? ???? ?????? ??????? ??? ????? ?????????? ?? ?? ??????? ??? ???? ?????? ???? ??? ????? ?? ?????? ??? ?????????? ?????? ???? ????????? ?????? ???? ????? ???.