??????? E ?? ??????-???? ??????? ????? ??????? ?????? ??? ?????? ????? ???? ??? ?? ???? ??? ??????? ?????????? ??? ????? ??:

1. ???? ??????? ???? ?????? ????????.
??????? E ?????????????? ?????? ???? ????, ??????-???? ??????? ????????? A20 ??????? ????, NF - κ B ???? ??????? TNF - α - ???????? ??????? ????? ????? ????, ?????? NF - κ B ?????????? ????????? ?????? ??? ???? ??????? ??????????? ?????????? ??? ????.
NF - κ B ??? ????????? ????? ?????????? ??????? ??? ??????? ?????? ?????? ??????? ?? ???, ??? ??????????????? ??????? ???????? ???? ??????? ??????????????? ????????? ??? ?? ?????.
2. ?????? ????????? ?????? ?? ????????? ????? ??? ?????.
??????? E, ?????? ????????? ???? ???????? ?? ????????? ????? ???? ????? ????? ????? ??? ???????? ????????? ????? ??????? ???? ??????? ????????? ?????? ???????.
3. ???? ??????? ????????????? ???? ????? ?????? ???????
????????????? ?? ??????????? ???? ???? ??????? ??? ????? ?????-??????????? ?? ???????? ???? ????? ?????? ??? ????? ??? ???? ??????? ????????? ???? ????.
????? ??????????? ???????? (?????????????????? ????) ????????? ??? ?? ???? ??????? ???? ???????? ????????? ???????? ???????? ???????.
4. ?????????????? ??? ??????????????? ??????? ?????
??? ??????????? T ?? B ??? ??????? ????? ?? ?????????????? ????????? ??????? ????? ???? ?????????????? ????? ??????-???? ??????? ??????????????? ???? ?????? ????.
?????????????? ????? ??? ??????? ?????? ?????, ????? ???????? ??????????????? ?????? ????? ?? ????????? ???? ????? ???? ??????? ????????????? ?????????.
??????-???? ??????? ?????? ?? ??????? ??????
??? ???????: ????????? ???? ?? ????? ??????? ???? ????? ??? ??? ????? ?? ?????? ???? ????, ??????????? ??????????????? ???????, ?? ????? ?????? ??? ????.
??????? ???? ??????? ???: ?? ?????????, ???? ?????? ??? ?? ???????? ???? ??????? ??????? ??? ????? ???? ?????? ?????? ??.