????????? ????? ??????, ?????? ??????? ?? ??????? ???????? ?????? ????? ???? ????? ????, ?? ???? ?? ??????? ?????????? ????? ???? ??????? ?? ?????? ?????? ????? ??????? ???? ??? ???? ?? ??? ??????? ?????. ?????? ????? ??? ???? ?? ?????????? ???? ????? (?????????? ???? ?????) ??????? ??, ????, ????? ???? ????? ???????? ?????? ???? ????? ???? ????? ??? ???? ????????. ?????????? ???? ????? ???? ??? ???????? ????? ??? ??? ??? ?? ???????? ???? ??????? ???? ????? ????. ?????, ????? ???? ????? ???? ??? ??? ?????????? ??????? ????????????? ?????????? ??????????? ?? ????? ???? ????? ?????????? ???? ????? ??? ???????? ??????? ??? ????? ?????? ????, ?????????? ???????????? ????? ??????? ???? ?? ??.

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????????????? ??? ?????? ?????? ?????????? ?????? ???? ????? ???? ?? ??? ????? ??? ?????? ?????????? 5-????????????????????????? (5-HT, ?????????? ???? ????????) ?? ??????????? ??. ????????????? ?????????? ???? ?????? ???????, ??????, ???????????? ???? ????? ?????? ??? ??? ????? ??????? ?? ?? ??????? ????? ?????????? ?????? ?? ??. ? ????, ????????????? ?? ??? ?????????? 5-HT ? ???? ????? ?? ????? ??????????? ??????? ?????? ??????? ??. ?????, ??????? ???? ??????? ????, ????????????? ?????????? ????? ???? ??? ???? ????????? ????? ???? ????? ???? ?????? ???????? ????????? ??? ??????? ???? ??????, ?????????? ???????????? ?????? ?????? ??????? ???? ???.

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?????, ?????????? ??????? ???????? ????? ?????????? ???? ?????? ???????? (CMS) ???????? ????? ???? ????? ?????? ???. ????? ????? ??? 21 ?? ?????? ????? ?????? ?????, ??????? ???? ?? ???? ???? ?????? ???? ???? ????????? ??????? ??? ?? ???, ???? ??????? ???????, ????????? ?????? ??????? ???. ????????????? ???? ???? ??? 21 ? ??????? ???????? ???, ????? ?????? ???? ???????? ?? ?????? ???????? ???? ???????? ???????? ?? ????. ????? ???????? ?????? ???????? (OFT), CMS ??????? ????? ????? ?????????? ?????? ????????? ???? ????? ???? ?????? ???? ??? ???? ??? ?? ???, ????? ???????? ?????? ??????? ?????? ????? ???? ?? ??? ????. ????? ?????? ?????? ???????? (TST), CMS ??????? ??????? ???? ???? ?????? ???? ??? ???? ??? ?? ???, ?? ??????????? ???????? ???? ????? ???????? ????. ? ????, CMS ??????? ??????? ???? ????? ?????? ???? ??? ???? ?? ????? ?? ?????? ???? ??? ??? ?? ???, ????? ???????? ??????? ???? ????? ?? ?????????? ???????????? ???? ??? ?? ????.

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????, ?????????? ??????? ??????? ????????????? ?????????? ?????? ?????? ??????? ?????????? ??????????? ???? ???. ????????????? ???? ???? CMS ??????? ??????? ?????? ????????????? ????????? ?????? ???? ??? ??? ?? ??? ???, ???? ?? ?????????? 5-???????????????????????? (5-HT) ?? ????????? ????????? ?????? ???? ??? ???? ?? ??? ????. ??????? ???????????? ???????? ??? 5-???????????????????????? ?????????? ??????? ?????????? ?? tph1 ?? mRNA ?????????, CMS ??????? ??????? ??? ?????? ??? ?? ?????? ???? ??? ???-??????? ?? ??? ????, ??? ?????? 5-HT ????????? ? ???? ?? ??????????? ???????? ??? ?????. ?????? ???????? ??????? ????? ??????? ?????? ??????? ?????????????-5-HT ?????????? ??????? ????????????? ??? ???? ??? ????, ??? ??????????? ??? ??????? 5-HT ???????? ?????????????? ??? ?? ?????.

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????????????? ?????-????? ????? ???? ?????? ???? ?? ?????? ????, ??? ?????????? 5-HT ?????? ?????? ???????? ?????? ????????????? ??? ?????? ??????????? ??? ??? ??? ???????, ??????? ?? ???? ????? ???? ???? ????? ??????????? ???????????? ??????? ?????? ??????? ??. ?????????? ?? ???? ????? ???????? ??????? ?????? ???????? ?? 5-HT ????????????? ??????? ?????????? ???????? ?????????? ???????? ????????? ???. ????????????? ???? ???? ??????? ????? AgRP ?? OX1R ???? ?????? ???????? ?????????? ??? ???? ????? ????????? ?????? ???? ??? ??? ???? ????, LEPR, MC4R ?? 5-HT1B ???? ???? ????? ??????? ??? ?????? ????????? ??? ??? ?????. ?????? ???????? ?????????????-5-HT ??????? ????? ??????????? ?????? ??????? ?????? ???????? ????????? ???? ???????? ??? ???? ??? ???? ????.

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?????, ????????????? ??? ??????? ??? ?????? ??????? ???????? ????? ??????? ?? ???? ?????? ???????? ??????????? ???? ?? ?????? ????????????? ??????? ????? (100mg/kg ?? 300mg/kg) CMS ?????? ??? 21?? ?????? ?????? ???????? ??? ??? ???. ????????????? ???? ???? ????????????? (300mg/kg) ??? ?????????? ??? ??? 21? ????????????? ???, ????? ???????? ?????? ?????? ?? ???? ??????????? ?????? ?????? ???? ??????? ?????? ?? ?????? ??????? ???? ??????? ?????? ???? ??? ?????????? ?? ????, ????????? ??? ???? ????? ???? ??? ?? ?? ??? ??? ??????? ?? ?????. ??????? ?????????? ?????? ?? ????? ??? ??????? ????????????? ?????????? ??????? ???????? ????? ?????????? ?? AgRP ?? OX1R ???? ???? ????? ?????????? ??? ???? ??? ?????? ?????? ??? LEPR, MC4R, 5-HT1B ?? 5-HT2C ???? ???? ????? ??????? ??? ???? ????????? ??? ???????? ??? ??? ????. ????????????? (100mg/kg) ??????? ??? ???????? ???????? ??????? ?????? ???? ????????? ???????? ?????, ???? ???????? ???????????? ???? ????? ??????? ??? ?????????? ???????? ??????? ??????????? ??? ?? ????? ????? ???.

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???????? ???? ????????? ?????????? ?????? ?? ????? 5-HT, ??????????? POMC, AgRP ?? ??????? ??????? ?? 5-HT1B ?? 5-HT2C ????????????? ?????? ????????, ???? ????? ?????????? ??? AgRP/NPY ??????? ??????? ??? ????, ???? ????? ?????? ?? ??????? ???????? ?????????? ??? POMC ??????? ??????? ??? ????, ???? ???? ????? ?? ?? ??????? ?????? ??????????? ??? ??? ?????. ??? ?????????????-5-HT ?????? ????? ?????????? ????? ?????????? ????? ???? ?????? ???? ????????? ?????? ?????.

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???? ????? ??????? ?????? ???????? ?? 5-HT ?? ?????? ????? ???????? ????????? ????? ???? ?????????? ????? ??????????? ??????? ??? ????? GT1-7 ? ?????? ???. ??????? ???? ??????? ??????? ????? ???? ????? ??? 24 ?? ???? ?????????????? (CORT) 10μM ??? GT1-7 ??? ????????? ???. ????????????? ???? ???? AgRP ?? OX1R ???? ???? ????? ?????????? ??? ????? ????????? CORT ?????????? ????? ?????? ???? ??? ??? ???? ??? ??? MC4R, 5-HT1B ?? 5-HT2C ???? ???? ????? ??????? ??? ????? ????????? ??? ??? ????. ??? 2 ?? ???? 0.1μM 5-HT ??? ????? ????????? ???????? ???, CORt-???????? AgRP ?? ??????? ????? ????????? ????????? ?????? ???? ??? ???? ?????? ???? ???, MC4R, 5-HT1B ?? 5-HT2C ????????? ????????????? ?? ?????. ??? ??????????? ??????? ?? 5-HT ?? ???? ?????? ????? ???????? ?????? ????.

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????? ??? ????????????? ?????????? ????????????? ?? ??????? ?????? ??????: ??????? ????? ?????? ????????????? ?????? ??? ???? ???? ??? (P

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??????? ????? ???? ????? ???? ????? ?? ?????? ??????? ???? ???????? ??? ????????????? ?? ?????: ??? ???????????? ???? ????????????? ??????? ??????? ????? ???? ????? ????????? ???? ?????? ???????? ?? ?? ??? ?? ????? ??? ???????? ??? ?? ??? ????? ??? ?????? ?? ?????? ??????? ???? ???????? ???? ?????? ???? (P

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??????? ???? ????? ??? ??????????? ???? ?????? ?? ???? ????? ?????????? ?? ????????????? ???????? ??????: ?????????????? ??????? ??????? ????? ???????? ??? ??????? ???? ??????? ?????????? ?? ARC ?????? c-fos ?? AgRP ????????? ?????? ???? ??? ???? ?? ??? ??? LEPR ?? ????????? ?????? ???? ??? ??? ?? ??? ???? (P

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??????? ???? ??????? ?????????? ?? 5-HT ?????????? ??????? ????????????? ?? ??????: ????????????? ?????????? ??? ?????? ????????????? ?? 5-HT ?????? ?????? ???? ??? ???? ??? (P

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???????? ??????, ??? ??????????? ???? ????? ??????? ????? ?????????????-5-HT ?????????? ?????? ????????? ???????? ??????????? ???? ????? ?????? ????? ???? ??? ??? ????, ?????? ?????????? ???? ????? ??????? ?????. ????????? ??? ???????????? (300mg/kg) ????? ????????????? ???????, ?????? 5-HT ?????? ??? ???????? ??? ????, ??????????? 5-HT1B ?? 5-HT2C ????????????? ??????? ????, AgRP/NPY ??????? ????, POMC ??????? ??????? ????, ?? ?????? ???? ???????? ???? ?? ????????? ???? ?????? ???????? ???? ?????? ????.

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??? ??????? ????????? ?????? ?????????? ?????????? ????. ?? ??????, ??? ???? ?????????, ???? ?? ????? ???? ????? ?????????? ????? ?? ?? ??????? ????? ?? ??????. ???? ????? ????? ?????? ????????????? ????? ??? ??????, 5-???????????????????????? ????????? ??? ???? ???? ?? ????, ???? ?????? ?????????? ???? ??????? ???? ??? ????, ?????? ???????, ?????? ?? ??????? ??? ?????? ????? ??? ???? ?????, ???????? ?? ??????? ?????????? ????? ??? ???? ??? ???? ?????????? ?????? ?? ??. ??? ??????????? ????????????? ?? ??? ?????????? 5-????????????????????????? ?? ?????????? ??????? ???? ?? ???, ?????-??????-???? ????? ??????? ?????? ?????? ?????????? ??????? ???? ????, ????? ???? ????? ?? ???????? ???? ?? ?? ???? ?????????? ????? ???? ?? ????? ?? ????? ?????.

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?????????? ?? ??????, ?????????? ?????? ??? ?????? ????? ???? ????????? ????? ????? ???? ???? ??????? ???????? ???????? ????. ?????????, ??????, ????, ?? ????, ??????, ????? ???? ????? ???? ?????? ????????????? ???? ???? ???? ??? ?????? ????? ?????? ????????????? ????? ???? ?????? ??????, 5-????????????????????????? ????????? ?????????? ??????, ?????? ?????????? ????? ?????????? ?????? ?? ???? ???? ????? ???????. ???? ?????, ?????? ????????????? 100% ??????? ?? ?????? ????? ?? ????????? ?? ?????. ? ????, ???? ?????? ????? ???????????? ????????????? (500mg/kg ? ????) ?????? ????? ?????? ??? ???? ?????? ???? ??? ???. ??????, ????? ???? ???????????? ??, ????????????? ???????? ????????? ??? ?????, ????????????? ?????? ???? ??? ?????? ????? ??????? ???????.

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?? ?????, ?????, ???????, ??? ???? ???????? ???????? ????? ?????? ????????????? ?? ?????????? ????????? ????? ???? ??????, ????? ???? ?????? ?? ??????? ???? ?????? ?????? ?????? ??. ?????????? ??????? ??? ?????, ??????? ?? ??????? ???????? ?????? ????? ?? ?????? ?????? ??? ??????? ?????? ???? ????? ?? ?????? ?????? ????? ???? ?????? ????? ??. ?????? ??????? ?? ?????? ???? ????? ?????????? ????? ??? ????? ??? ???, ??????? ??? ??????? ?????????????? ????????? ??? ????? ?????? ??.

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????? ??????, ??? ???????? ????????????? ?????????? ???????????? ????????????? ??????? ???????? ????? ?????????? ???? ?????? ?????????? ???? ??? ??? ????? ???? ?????, ???????? ???? ?? ?? ???? ?????????? ????? ???? ?? ????????????? ?????. ???? ?????? ????????????? ???????? ???????? ?? ???????? ???????? ????? ???? ???????? ????? ?????????? ?????? ????, ??? ????????? ???????? ???? ??????? ?????? ??????? ?? ?????? ??????? ?????????? ????? ???? ?? ????? ??? ??? ?? ??. ???? ???? ?????, ???????? ????????, ??? ????? ?? ??????? ?????????? ?????? ?????? ??? ??????? ?????? ????? ???????? ????? ??? ???? ???? ??? ??? ???????? ???? ?? ???? ???? ??? ??????? ????.