??? ?????????? ?????? ?? ????? ??????? ?????? ??????? ??????? ???????? ???????????? ?? ??? ???, ??????? ?????? ??????? ??????? ????? ?? (??????? ????? ????????? ????), ????? ??? ????? ??????? ?? ???? ?????? ?????? ?????? ?????? ????. ?????????? ?????? ?????? ???? ????? ???, ????? ???? ???? ???? ???? ?????? ?????? ??. ??? ????? ?????????? ??? ????? ?????? ?????:

?

1, ???????/????? ?????? ????????

?????????? ??????? ????? ????????? (rUTI) ?

??????????: ?????? ??? ???????? ????? ???????????? ??? ?????????????? ????? ??????? ???? ????, ??????????? ???? ???? ??? ???? ????? FimH ?????? ??????? ?????????? ?????????? ??? ??? ?????? ??? ??????? ??? ????? ????, ?????????? ???????? ??? ?? ??????? ????? ???? ????? ???????.

??????:

?????????? ???????????? ??? ???????? ????? ???? ??? ?????? ???????????? ???????? ?? ?????, ????????? ??? Escherichia coli ???? ??? ?? rUTI ????????? ???? ????? ?????? ??????? 1.5-2 ?? ??? ???????????? ???? ?????????? ????? ?????? ?? ??? ?????????? ??? ???????? ??? ????.

??????? ??????? ??????? ????? (EAU) ?????????? ?? rUTI ?????????? ????????? ??? ?????????? ???? (?????? ?????: B).

????: ??? ????????? (???? ???? ????????? ????? ????), ?????? ???????? ?????????? ??????????? ???????? ?????.

???????: ????????? ???? ????? ???? ?? ??? ????? ???????? ????????? ???????? ?????????? ????????????? ?? ?????; Escherichia coli ???? UTI ??? ??? ????? ??????.

2, ??????? ?????? ??? ????? ???????? ??????? ??? ????????

???????? ?????????? ?????? (CDG) ????????? ?????

?

??????????: MPI-CDG (CDG-Ib ?????) ???? ???? CDG ?? ??????, ??????-6-????????, ????????-6-???????? ??? ????????? ??? ?????? ???????????? ?????????? (PMI) ?????? ???, ?? ??? ???? ?????????????? ???? ??.

?????????: ?????? ??? ???????? ????? PMI ??? ?????? ??????-6-???????? ?????? ??? ?????? ???????????????? ????????? ??? ???????? ??? ?? ?????.

?????? ???????:

CDG ?? ????????? ?? ???? ?? ???? ????????? ???? ?? MPI-CDG ???? ?????? ?????? FDA ?????? ????? ?? ??.

????? ???, ???? ?????? ?????????? ?? ???? ????????? ??? ????? ?? ?????? ???? ????????? ??, ????? ????? ???? ????? ??? ?????? ??.

?????: ALG-CDG ???? ??????? CDG ?? ???? ???? ????? ???????? ??????? ?????? ?????.

?????? ???? ?????????????? ??????? ?? ??? ???? ????? ???? (??????????? ????? ?????? ???????)

?

??????????:

??????? ?????? ???????? ??????: ?????? ??????? ??????????? (TAMs) ??? ??? ???????? ?????? ????????????? (MRC1) ?? ?????? ????? ??? ?? ??? ??????? ????????? ?????? ??? ??? ??? ?????.

?????????????? ?????? ??????? ?????: Mannose ??????? ??? TAM ?????? ??? Mannose ????????????? ??????? ????, ?????? ??? ?????? ??? Mannose glycated antigens ????? ????? ????? ????, ?????? ?????????????? ?????? ???? ?????? ?????.

??????? ???????? ????????? ???? ?????? ?????: ???? ??????????????, ?????? ?? ??????? ????????? (?????????????? ????) ??????? ????? ?????? ?????? ?????? ???? ??? ??????? (???? ??? ???????? ?????????? ???????????? ???? ????????).

???????: ???? ????????????, ???????? ???????? ?? ?????????? ?????? ??????? ???????? ??????? ?????? ??.

????? ????/??????? ????? ????? ??

?

??????????: ???????? ?????????? ?? ????????????? ???? ??? ???? ??? ???????? ????? ???? ???? ?????? ????????????? ?? ??? ????. ?????? ??? ??? ???? ????? ?? ?????.

???????:

????????? ?? ???? ?????????? ?????? ?? ????? ?????? ????? ???????? ??????? ??? ??? ???? ?????? ?? ???? ????.

???????? ????? ??? ??? ???????? ?????? ???????? ???????? ???????????? ????? ??????? ??? ?? ????? (???? ?????? ??????).

?????: ????? ????? ?????? ????? ???????????? ???? ?????? ?????? ?? ??? ?????????? ??? ?????? ???????? ???.

3, ???? ?? ????? ??????? (????????? ?? ???? ?????)

?????? ???? ??????? ???? (IBD) ?? ?????? ???? ???????????? ??

?

????????:

?????? ??? ?????? ???????? ?????? ??????? ?? ????? (??????????? ?????????? ?????????? ?????) ?? ????????? ?????????? ???? ???????.

??????????????? ????? ????? ???? ?????? ???????? ???? ???????? ?? ??????????????? ???? ?????? ?????.

?????? ???????: ???? ????? (???????) ????? ??????? ?????? ???????? ????, ????? ???? ??????? ?????.

????? ?????????????? ??? ??????? ??

?

??????: ????????? ??????????????? ?????????? ?????????, ????? ?? ??????? ??? ?? ?????????? ???????????? ??????? ??. ?????? ??????? ????? ??????????????? ??? ??????? ?? ?????.

????????: ???? ?????? ?????? ?????? ??????? ??? ????? ?? ??? ???? ?????? ???? ????? ????????? ????.

??????????? ??????? ????????? ??

?

?????: ??????? ???? ????? ??? ??? ???????? ?? ???? ??????? ???? ?????????? (AGEs) ??? ???? ?? ??? ?????? ??????? ??? ??. ?????? ?????????? ??????????? ?? ??? ??????? ??? ????? ???????? ??? ???????? ???, ??????? ?? ??????? ??? AGEs ????? ??? ?? ?????.

??????: ???? ?????? ??????????? ???? ????? ????????? ???????????? ???????? ???????? ?? ????, ???? ??????? ???? ?????.

4, ?????? ?? ???????

?????????? ??????? ??????

Escherichia coli ???? ??? ???? ??? ?????? UTI ????????? ?????????? ??; ????????? ??????? ???? ?????????? ???? (????????? ?????? ???????????????? ?????)

CDG ?????????? ?????? ????? ??????? ?? ???? ???? ????; ???? ??? ???????? ?? ????? ???? ????? ??? ?????? ??.

?????? ?????? ?????? ??????????? ???????????? ?????; ??? ???????????? ????? ??? ??? ???; ??????? ????????? ??????? ?????? ??? ???? ?????? ??????? ?? ?????.

????? ?????? ????? ??? ??? ??????? ???????????? ?????????? ?????; ????? ??? ??? ?????? ????????? ???????? ?????? ??????????.

??????? ???? ?? ?????????? ???????????? ?????? ?????? ???????; ???? ???????? ?????? ?????? ?????? ????????; ??????? ???????? ???? ????? ?????? ????.

5, ????? ??????? ?????

???????? ?????????? ?????? ????????: ??????/?????? ????? ????? ????? ???? ?????? ????? ???? ?????? ????? ?? ???? ???? ???????? ?????.

?????? ???????? ?????????????: ??????????, ?????????????? ?????????? ????? ?????? ?? ????? ???? ??? ??? ?????? ?? ?????? ?????? ?????? ?????.

?????? ??? ?????????: ?????? ??? ????????? ?? ???? ???? CDG ?? ???? ?? ?????????? ???? ???? ???? ??????? ?????.

????????? ??????????? ??????-?????? ???????? ?????: ???? ??? ??? ?????? ?????? ?????? (UTI ????????? ???? ?????? ?????? ????).

????? ???????? ???? ??????: ??? ???? ????? (UTI) ?? ??? ??????? (CDG) ?? ????? ?? ???????? ???.