??????? B3, ???????? ???? ????????, ?? ?????? ????? ?????? ????? ??????????? ????????????? ???? ??? ???? ????????? ??????? ???????. ???? ?????????? ?????? ?? ????? ??????? B3 ?????? ????? ?????????? ???????????? ?????? ?? ????, ??? ????? ?????????? ?????????? ??? ????, ??? ??????????????? ??????? ??? ??? ?????.

???????? ???? ??? ????? ???? (NAFLD), ????? ??????? ????? ??? ?????? ???? ??????? ?? ???, ????? ?????? ?????? 150 ?? ??? ????? ???, ??? 10-20% ?? ???????? ???????? ???? ???????????????? (NASH) ??? ?????? ?? ???, ??????? ?????? ??????? ?? ????? ??? ???? ????? ??????? ?? ???, ???? ??? ???????????? ??? ??. NASH ??????? ?????? ?? ??? ???????? ?? ????? ?????? ???? ????? ????? ??? ?????? ???? ???? ???????? ??.

??????, ??? ????-???? ????? ?????????? ???? ?????? ????? ??????????? ?????? JAMA Network Open ?????? "???????? ???? ??? ????? ??? ??? ?????????? ??? ?????? ???????? ???????? ?? ??? ???????" ?? ??????? ????????? ????????? ??? ??? ???.

??? ??????????? ???????? ???, ???? ?????????? (≤18.4mg/?????) ??? ???????????? ?? ???? ???, ????? ?????????? (≥26.7mg/?????) ??? ???????????? ???, ??????? B3 ??????? ??? ??? ?? ???????? ???? ??? ????? ??? ??? ?????? ??? ????? ???? ??? ?????? ??? ?????, ????? ???? ??? ?????? 30% ???? ??? ????? ??? ??????? ?? ??? ????.

??? ????????? ??, ??????????, ???????? ???? ??? ????? ??? ??? ???????? ???? ??????? B3 ???????? ?? ????? ???? ???? ?????? ??? ?????? ??? ???????? ????????? ???, ???????? ??? ??????? 53 ?? ?? NAFLD ?????? 4,315 ???????? ????? ?????? ?? ???? ??????? ????????? (NHANES) ???? ????????? ???? ??????? B3 ???????? ???? ????????.

??????? B3 ???????? ?? ?????? ???????????? ???????? ????? ???? ??: ??? ????????? ??????? (≤18.4mg/?????), ?????? ????????? ??????? (18.5-26.6mg/?????) ?? ??? ????????? ??????? (≥26.7mg/?????).
??? 8.8 ? ???????? ??? ?????? ???????, ???? ??? 566 ?? ?????? ?? ???, ??? 197 ?? ??? ?????? ??? ???? ???? ???.

???????????? ???? ????, ???? ?????????? ??? ??? ????????????? ????????, ????? ?????????? ??? ??? ????????????? ????? ???? ???? ?????? ??? ?????? 30% ???? ??? ????.

?? ?????, ????? ?????????? ??? ??? ????????????? ??? ?????? ??? ?????? ????? 35 ???? ??? ?? ????? ??? ?????????? ?????? ?????? ?????.

??????? ??????????? ????? ??????? B3 ???????? ?? ?????????? ?? ????? ???? ???? ?????? ??? ?????? ??? ?????? ???? ???????????????? ???? ??? ???, ?????????? ??? ?????? ?? ???? ??? ????????? ???? ???????? ??? ??????? ???? ?????? ??? ???.

??????????? ????, ???????? NAD ?????????? ??????????????? ???? ?? ??? ????? ??? ????????? ?? ????????? ????? ???? ?????? ???????? ??? ???? ??. ????? ??????????? ?????????? ????? ????????? ??? ?????? ???? ?????? ?? ???? ??? ????? ??? ???????? ??? ?? ???? ?? ?????? ?? ??. ????? ?????? ??????????????, ???????? ????? ?????????? ?? ??????? ??????? ?????? ?? ???? ??????? ?? ???????????? ?????????? ??????? ??. ??? ?????? ????????? ????? ??? ?????, ????????????????? ???????????????????? 2 ?? NADPH ????????? ??????????????? ??????? ????? ?? ??????? ??? ???? ????????? ????? ??? ?? ?????.

2023 ??????????? ???????, ??? ????-???? ????? ?????????? ???? ?????? ????? ??????????? ?????? "?????? ???????? ???????? ?? ???????? ???? ??? ????? ??? ??? ???????????: NHANES 2003-2018" ?? ??????? ???? ?????? ?????? ?????? ??????? ??????????? ????????? ??? ??? ?? ?? ????? ????? ???.

??????????? ???????? ??? ??????? B3 ??????? ???????? ???? ??? ????? ??? ??????? ?????? ??? ??? ????, ????? ???????? ?????????? (≥29.2mg/?????) ??? ??? ???????? ???? ??? ????? ??? ??????? ?????? 31% ???? ??? ????, ??? ???????? ?????????? (≤16.3mg/?????) ??? ??? ???????? ????.

???????? ??? ??? ??, ??????? B3 ??????? ???????? ???? ??? ????? ??? ?????? ??? ?????? ?? ???????? ???? ??? ????? ??? ??? ?????? ??? ????? ???? ???? ?????? ??? ?????? ??? ?????? ??????? ?? ????? ????. NAFLD ?????? ??? ????? ???? ???? ?????? ??? ?????? ??? ????? ???? ??????? B3 ?? ???????? ???????? ?????? ????? ???? ???????? ??????? ?????? ??.