???? ?????? ???? ??? ??????? ???? ????? ???? ????? ????? ?????? ?? ???????? ????? ???? (ALD), ????? ????? ????? ????? ????? ???????? ????, ??? ???????? ??? ??????, ???????? ??????????, ???????? ????? ???????????? ?? ???????? ???????? ?????? ??. ??? ???????, ????? ???????? ????? ??? ??????? ?????? ??????????? ???????? ?? ??.

2024 ???? 2 ?? ???, ??????? ????? ?????????? ???? ??????, ??????? ?????? ????? ?????????? ?????? ????, ????? ??????? ?? ?????? ????? ?????????? ???? ?? ?? ??????? ??????????? ?????? "?????? ????? ????? ???????? ????? ????? ??? ????" ?? ??????? ???? Cell Host & Microbe "Bacteroides acidificaciens and subsequent ammonia detoxification" ?????? ??????? ????????? ??? ??? ???.

????????? ?????? ????? ????? ??????? ???? ????? ????? ??? B. ?????????????? ???????? ???? ??? ??? ???????? ???? ????? ????? ????? ??? ??? ?? ???? ????? ???.

?????????? ??, B.accifaciens ??? ??????? ?? ???????? ???????? (BSH) ???? ??? ???? ?????????? ??????? ????. ?????? ???? ??? ?????? ??????? ????????? FXR-FGF15 ?????? ??????? ????, ?????? ???? ??????????????? ?????? ????, ?????????? ?? ?????????? ????????????????????? (OAT) ????????? ?????????? ????, ?????? ?????? ??? ???????? ?????????? ????????? ??? ?????????? ?????????? ????. ?????? ??????? ???? ??????????? ???? ??? ????? ??? ???? ??? ????.

??? ???????????, ?????????? ?????? ??? ??????? ???????? ??? ???????? ????? ???? ??? ?? ???, ????????? ?? ??? ???? ????? ?? ???? ?????? ???????? ????? ??? ???????? ????? ????? ?????? ????? ?? ????? ????????? ???.

????????????? ???? ???? ????????? ?????? ????? ??????? ????? ??? ???????? ????? ??? ?????? ???? ??? ?????????? ?? ????, ????? ?????????? ???? ????? ?? ????? ????????????? ????????? ?? ???? ???????? ??? ????? ??????, ??? ???? ?????? ????? ?????? ???? ??????? ??? ???? ?????.

?????? ????? ????? ?????? ????????????? ?????? ???? ??? ?????? ?? ???? ??????, ???????? ????? ????? ??????? ??????????? ???? ?????? ??????? ????? ???? ?????? ????????????? ?????? ?? ????? ???? ?????????? ???????? ????????? ???.

???? ???????? ???, ????????? ?????? ????? ????? ??? ?? ??????? ?????????????? ???? ???????? ?????? ?????? ???????????????????? (ALT) ?? ??????????? ???????????????????? (AST) ?????? ??? ?? ????, ????? ?????????? ?? ??????? ?????? ??? ??? ????, ????????? ?????? ????? ?????? ?????????????? ??????? ???? ???? ???????? ALD ??????? ?????? ?? ???? ???? ???? ????? ???.

???????? ????? ????? ????? ??????? ????????? ?????? ????? ????? ????? ??? ????????, ????? ?????????? ?? ??????? ???? ?????? ?? ????, ????? ??????? ????? ?? ????????? ????? ??? ?? ????, ???????? ????? ??? ????????? ?? ????????? ???????? ????????? ?????? ????? ?? ?????? ????????? ?????? ??? ???? ??????????? ???????? ??????.

??????????? ???????????? ????? ?????? ????? ??????? 25-30?? ?? ?? ???? ?????????? ???????? ?????? ??????? ?? ??? ????? ???? ?? ?????? ??????? ?????????? ???? ?? ????????? ????? ???????. ???????? ?????? ????, ?????? ?? ????? ?????? ????? ????? ??????? ????????? ?? ??? ??????? ?????????? ???????? ???? ?????? ?????.

????????? ???, ????????????? ???? ????? ????????? ?????? ????? ????? ??????? ???? ????? ????? ????? ??????? ??????? ????? ????? ????? ????? ???? ?????? ?? ???? ??? ?????? ?????? ???????? ?????? ?? ???? ????. ??? ????????? ??????? ?????? ????????? ?? ?????? ?????????? ??.

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