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    2025-01-15

    ???? ????? ?????????? ?????? ?? ????? ??????? C ?????????????? ???????, ??????????????? ?????? ?? ??? ?????? ?????? ????? ????? ?????? ????????? ??? ????. ??????? C ??????? ?????? ????? ???? ?????? ?????? ????????? ????, ???? ??? ?? ??????? ???????? ?????? ?????? ??? ?? ?????.

    ??????? (MM) ??? ??? ????? ??? ????? ??????? ????????? ????????? ?? ??? ?? ??? ?????? ?? ?????? ????? ????? ??, ????? ??? ???????? ??? ?? ??? ?? ????? ??????????? ?? ?????????? ??. ?????? ??? ?????? ??? ??????? ??????? ????????? ??? ????? ????.

    ??????, ?????? ?????? ?????? ????? ???????? ????? ?????????? ?? ?????? ????????? ??????? ????? ?????????? ??????????? ?????? "??????????? ????? ????????? ??? ???????? DNA ?????? ???????? ??????????? ???? ?????? ????" ?? ?????? ?????? ??????? ??? ???????? ?? ?????? ???????? ?? ?????? "?????? ??????? ??? ???????? ?? ?????? ???????? ?? ?????? in vitro ?? ex-vivo DNA ???? ???????? ?? ??????? ????? ??? ????" ?? ??????? ???? ??????????? ????????? ??? ??? ???.

    ??????? ?????? ??? ??? ??????? C ??? ????????? ???????? ?????? ??? ??? ?????????-???????? DNA ????? ???? ?? ???? ???? ?????? ??? ??? ??? ?????????? ?? ???? ???? ???????????? ???? ?? ??? ???, ??? ????? ????? ??????? ????????? ?????????? ??. ???????? ??? ??? ????, ?? ??????? ??????????? ??? ????.

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    ??? ????????? ??, ?????????? ????? ????? ???? MM ??? ???? ??????? ??????? ?? ???, ????? ???????????? ??? ?????????? ??????????? ?????? ?? ???, ???????????? ????? DNA ????? ???? ???????? ??????? ??? ????? ???? ?????????? ???? ????? ???? ??????? C ????????? ???.

    ?????????? ??? ???? ??? ??????? C-???????? DNA ???? ?????? ??????? ?? ???, ???????? ??? ???, ???????????? (HaCaT) ?? ???? ???, ?????? MM ????? ?????????? DNA ???? ?????? ???????????? ??? ?? ???? ????, ?????? ??????? ????: ??? ????? ???? SK23 ???, ???????? ????? ???? SK28 ???, ????? ???? A375P ?? A375M ???, HaCaT ??? ??? DNA ???? ??????? ???????? ????.

    ?? ?????, ?????????? ???????????? (?????????? ???????????) ????? ???????? ?? ??????? ??? ???? ??? ????????? ????????? ?? ??? ?????????? ??????????? ??? ???? ????????? ??? ????? ??? ?????? ?? ???? ????.

    ?????? ????? ????????? ????? ?????? ??????? ???????????? ???????? ??? MM ??? HaCaT ?????? ??? ?????? ????? ????????? ??????? ?????????? ?????? ???????? ??? ?????? ????? ????, ??? ???? ??? ?????????? DNA ?????, ???? ????????? ?? ????????????????? ??? ?????? ?? ?????.

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    ????, ????????? ??????? C ??? ?? ????? ?????? ????????? ?? ??? ???????????? ????? DNA ???? ????????? ?? ??? ????? ?????? ??????? C ?? ???? ?????? ?????? ????????? ???.

    ????????????? ???? ???? ?????? MM ??? ????, ??????? C ????????? ????? ??? ??? ?? ?????????? DNA ???? ????? ?????? ???? ??? ???? ?? ??? ????, HaCaT ????? ?? ????? ?????? ???? ???? ????, ???????? ?????????? DNA ????? ??? ????? ????? ??? ?????? ?????.

    ?? ?????, ??????? C-???????? ?????????????? ???? ????? ??? ????? ???? SK23 ????? (18.5%) ???? ????? ??? ??? ????? ???? A375P ????? (14.2%) ???? ????? ??????.

    ??????? C ????? MM ????? ??????????? ???????? ?????????? DNA ????? ?? ?????????????? ????? ???? ?????? ?? ???? ?? ?? ??????, ?????????? DNA ??????? ???? ?????? ?????? ??????? C ?? ????? ????????? ?? ??? ?????? MM ??? ????, ??????? C ?????????? ????? ???????? DNA ??????? ???? ?????? ????? ?????? ???? ??? ???? ?? ????? HaCaT ??? ???? ???? ?? ???? ????. ??? ???? ??? ?????????? ????? ??? ????? ??? ?????? ??.

    ?????? ?????? ???, ?????????? ??????? C ????? ???????????-???????? MM ??? ???? ???? ?????? ???? ???? ????????? ?? ???, ??????? C ????? HaCaT ????? ??????? ??????????? ??? ??? ???? ?????? MM ????? ???????????-???????? ?????? ???? ?????? ?? ?? ???? ??? ???, ???? ?????????? ??? ????? ????? ??? ?????? ???.

    ????? ??????, ??????????? ??????? ????? ??????? C ????? ???? ????? ??????? ?????? ?? ????????????? ?? ???????????? ???? ?????? ?? ???? ????, ????????????? ????? ???????? ?? ?????? ????? DNA ????? ?????? ???? ??? ???? ??? ?????.

    ?????? ????? DNA ????? ???? ?? ?????? ??? ????? ???? ??? ???? ??????? C ?????? ?????, ????????? ????????? ????? ???? ????? ?????? ???????? ??? ???? ????, ?? ????????? ?????? ????? ?????? ??????? ?? ?????? ?????? ?????? ???? ????????? ??????.

    ??????? C ?????? ???????? ?? ??? ??? ?? ?????? ???? ????? ?? ????? ??????, ????? ????????? ???? ?????? ????? ???? ???????????? ??????? C ????????? ??? ?????? ?? ???? ?? ????????? ??????? ????.

    ??? ??? ??, ??? in vitro ??????????? ???????? ????????????? ?????????????? ????? ?????????? DNA ????? ???? ?????? ??????, ?????? ??? ??? ??? ?????????? ??????, ???????? ??? ????? ??????? ??????????? ??? ?????? ?? ????? ??????? ????? ???????????? ???? ?????? ?????? ???? ???, ?? ???????? ???????? ????? ???.