???????? ??? ????? ????? ????? ????????? ?? ??????? ???????? ??????? (PC) ???? ???????? ?????, ???? ?????? ????? ?????? ?????? ?? ??? ????? ???????? ??? ?? ??????? ??????? ???????? ?? ????????? ????? ?????? ??? ?????. ?? ??????????, ??????? ???????? ??????? ?????? ??? ?? ?????? ??? ????? ???, ????? ?????? ????????? ?????? ??? ????????? ????????.

?????? ????, ?????????? "??? ????? ?????, ?????? ????? ????" ?? ??? ????, ??? "?????? ?????" ???? ??? ???? ?????? ??? ???? ??. ??????? ???????? ?????? ??? ????????? ??????????? ??????. ?????? ???? ?????? ?? ???? ????? ???? ?????? ??????????? ????? ????? ???? ???????? ??????? ?? ???? ???, ?? ??????? ???????? ???????? ?????? ??? ??????? ?? ???? ??? ???????? ???????? ???? ?????? ?? ?????.

2024 ???????? 25 ?? ???, ?????? ??????????? ????? ??????????? ???????? ?????? ???????????? ??????? ???? ?????????? ??????? ??????? ?? ?????? ?? ????????? ??? ??? ???: ??????? K ????????????? ?????? ?????? ?????-????????? ?????????? PI 3-??????? VPS34 ??????? ????? ???? ??????? ?????????.

???????????? ??????? ????? ?????-????????? ????????? ?? ????????? (??????? K3) ??????? ???????? ???????? ???????? ???????? ?? ???? ????. ????????? ??? ??? ?????? ????? ?? ????? ????? ????? ??????? K ?? ???? ????????? ??????????? ?? ??? ??? ????? ??????????? ??????????????? ??????? ?????? ????? ???? ????? ?????????? ????? ?? ????? ?????????? ???????????? ?????? ?????.

????????? ?????????? ?????? ?? ????? VPS34 ??? ???????????????????? 3-??????? (PI3K) ?? ??????? ???????? ????, ?????????? ??? VPS34 ?? ??????????????? ??????? ?? ???? ????, PI3P ????????? ??? ?? ???? ????, ??????? ???????? ?????? ??? ??? ???? ???? ?? ????????? ????? ???? ?? ???? ?????. ?? ??????, ???????? ??? ?????? ?????? ?? ??? ?? ???? ??? ?????? ??????? ???? ?????????? ????? ????? ??. ?? ?????, X-????????? ??????????? ?????? (XLMTM) ??? ????????? ????? ?????? ?? ?????????? ???????? ??????? ??? ??? ?? ??????? ??????? ?????? ???????.

??? ?????????? ???????? ??????? ???? ??? ????? ?????? ???????? ???? ??? ??? ??????? ???????????????? ??????????? ???? ????? ??????? ????? ??? ???? ????????? ????? ???? ?? ?????? ??.

??????? RapidCaP ?? ???????? ??????? K ???? ????????? ????????????? ?? ????????? ??????? ???????? (MSB) ??? ?????-????????? ????????? ??? ????????? ????. ????? ???? ?????? MSB ????????? ?????? ???????? ??????? ???????? ???????? ???????? ?????? ?? ???? ???? ??? ????? ???????? ??????? ??? ?? ???? ???? ????? ???? ????.

???????? ??????, Science ?? ????????? ??? ??? ?? ??????????? ????? ??????, MSB ??????? ???? ???? ???? ?????-????????? ?????? ???? ???????? ??????? ?????? ??? ???????? ?????? ??? ??????? ?? ???? ????. ???? ????? MSB ????? PI3K kinase VPS34 ?? ??????????????? ?????? ??????, PI3P ????????? ??? ?????? ?? ????????? ????? ???? ?????? ???? ?? ??? ?????? ??????? ?????? ??? ??? ???? ???? ??. ?? ?????, X-????????? myotubular myopathy (XLMTM) ??, MSB ????? VPS34 ?? kinase ??????????????? ??????, PI3P ???? ???? ?????? ???? ?????? ?? ???? ????????? ????????????? ?? ?????.