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    2025-03-13

    2. ?????? (?? D-??????) ??? ??? ???? ???????, ????? ???????? ???? ???, ?????? ??????????? ??? ?????? ???????? ??????? ???? ???, ?????? ????? 90% ?? ?? ???????? ??? ???????? 30 ??? 60 ????? ???? ??? ??????? ???? ??????? ????? ????, ??????? ???????? ???? ???, ?????? ??????? ???? ??? ???????? ???, ????? ?????? ?? ???? ??? ?????????? ??. ?????? ???????? ?????????? ???????????? ???? ?? ?????, ??? ??????? ??? ???????, ?????? ??? ??????? ???? ?? ?????????????? ???????? ?????? ??. ??????? ??? ???? ????????? ???????? ?????? ?? ???????????????? ?????????? ?????? ?????? ???????? ??? ?????? ?????? ?????? ?????? ??????.
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      1980 ?????? ???, ??????? ???????? ????????? ????? ???? ??????????? ?????? ??????????? ?????? ??????? ?????? ?? ??. ??? ???????, ??????? ?? ???????? ?? ?????????? ?????? ???? ??? ???? ??????? ?????? ???, ??????? ???????? ????????? ???????? ??????? ?? ????????? ????????? ??????? ?????? ?????? ????????? ?????? ??????? ?? ??? ??.
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      ??????, ????????? ?? ??????? ?????? ???? ????? ??? ???, ?????? ??? ??? ??? ?????? ?????? ??? ???? ??? ??? ??? ?? ?????????? ????? ????, ?????? ?????????? ?????????? ?? ??????? ??? ??? ??? ??? ?????? ?????? ?? ???, ?????????? ??????? ?????? ????? ????, ?? ??????? ????? ??? ??? ??? ?????? ?????? ?????????? ???????? ??????? ?????? ??????? ????. ???? ??????? ????? ??? ????? ????????????? ??????????? ???? (UPEC) ?????. UPEC FimH ????????? ???? ?????????? ?????????? ??? ?????? ?????? ??? ?????? ?? ??? ??????? ????? ???????? ???? ????? ??????. ????? ????????? (M4284) ??? ????? ???? ?????? ????? ???. ??????? ????????? ??? ??? ??????????? ?????? ??? ??? 100,000 ???????? ???? ?, ????? ?? ?????????? ??????? ??? ??????? ??? ??????? ?? ?. ???? ??? ????? ?? ?????.
      2016 ?????????? ????????? ??, ??? 13 ?? ?????? ??? ??? ??????, ???????????? ????? ??????? ??? ?? ?????, ??? ????? ?????? ???? ??? ???????? ?? ??????? ???? ?????????? ?????? ???? ????????? ?????? ??. ?????????? ??????? ????? ????????? ????, ?????????? ?????? ???????? ????? ???? ??, ??????????? ??????? ?????? ????? ????? ????? ??? ???, ???? ???????? ??????? ????????. ?????? ???????? ?????????, ??? ???? ????? ???? ??????? ???????????? 4.5% ?? ????? ?? ???, ???? ???????? 33.3% ?? ???? ???. ?????? ????? ??????? ???????? ????????? ?????? ???? ??? ???? ???? ??????? ????? ???? ?????? ??????? ?????? ?? ???? ???? ????????? ?????? ???.