Sezvo zera repasi rose, zvirwere zvisingaperi zvine chekuita nezera seshuga, BP uye kufutisa zviri kuramba zvichiwedzera, uye zvirwere zvemetabolism izvi zvinoisa mutoro unorema kuvanhu vakwegura uye zvinowedzera njodzi yechirwere chemwoyo. Mwoyo unochinjawo zvakanyanya nezera, zvichizotungamira kune huwandu hwehurwere hwemoyo hunoenderana nezera.

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Chirwere chemoyo (CVD) chinotyisa kuhupenyu hwevanhu uye hutano hwezvirwere zvakajairika, zvinowanzoitika kune vanhu vanopfuura makore makumi mashanu, vane chiitiko chepamusoro, huwandu hwekuremara uye hukuru hwekufa. CVD inosanganiswa nemyocardial fibrosis, yakaderera autophagy, yakawedzera mitochondrial oxidative kusagadzikana uye kusaenzana kwemetabolism. Naizvozvo, kurapwa kwechikonzero chekutanga cheCVD ichiri dambudziko rekukurumidzira mune zvemazuva ano sainzi uye kurapwa.

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Mumakumi emakore achangopfuura, zvidzidzo zvakawanda zvakaratidza kushandiswa kwezvinhu zvakasikwa zvekudzivirira uye kurapwa kweCVD. Zvigadzirwa zvechisikigo ikirasi hombe yemakemikari masangano ane huwandu hwakawanda hwezvinhu zvipenyu, anowanikwa zvakanyanya kubva kune zvinodyiwa uye zvemishonga zvinomera. Zvidzidzo zvakaratidza kuti maitiro ekuita kwechigadzirwa chechigadzirwa chekurapa muCVD anosanganisira: kukurudzira autophagy, kunonoka kugadzirisa ventricular, kuderedza oxidative kushushikana uye mhinduro yekuputika, inhibiting apoptosis, uye kudzivirira musuru wemwoyo kurwisa ischemia kana ischemia / reperfusion (I / R) kukuvara.

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Zvigadzirwa zvechisikigo uye maitiro avo ekuita

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Enhanced autophagy

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Kuchembera cardiomyocytes vanovimba ne autophagy, lysosomal mediated degradation nzira, kubvisa zvingangoita chepfu mapuroteni aggregates uye akakuvadzwa organelles. Kurasikirwa kwe autophagy kunogona kukonzera kuderera kwekushanda kwemoyo. Chinangwa cheMammalian cherapamycin (mTOR), serine/threonine protein kinase, mutongi akakosha wekudya kwehomeostasis mumhuka dzinoyamwisa. Kushanda kwemTOR kunodzivisa autophagy, nepo AMP-activated protein kinase (AMPK) inoshanda seyakanaka regulator ye autophagy, kunyanya nekudzivisa mTOR yakaoma.

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Resveratrol ndeye yakasikwa polyphenol inowanikwa mune zvakawanda zvezvirimwa zvekudya, senge nzungu, cranberries, blueberries, uye mazambiringa. Iine hutano hwakasiyana-siyana hunogona kubatsira, kusanganisira anti-inflammatory, antioxidant, anti-kuchembera uye cardio-inodzivirira mhedzisiro yakadai sekuwedzera autophagy. Zvidzidzo zvakaratidza kuti resveratrol inogona kukurudzira autophagy nekuita AMPK kuburikidza nenzira dzakasiyana siyana. Uye zvakare, resveratrol inogona kukurudzira kupona kwesero nekuita iyo mTOR yakaoma 2 (mTORC2) nzira yekupona.

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Berberine inotorwa kubva kumidzi, rhizome uye bark yemiti yakawanda yemishonga uye ine zvakasiyana-siyana zvemishonga yemishonga, kusanganisira anti-inflammatory, antioxidant uye autophagy regulation. SeAMPK activator, berberine inogona kukurudzira autophagy nekuita AMPK uye inogonawo kuwedzera autophagy nekudzivisa mTOR.

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Curcumin inonhuwira yakabva kumhuri yeginger uye inowanzoshandiswa mumakiri. Curcumin inogona kukonzeresa autophagy nekuvharira PI3K-AKT-mTOR yekusaina nzira, pasi-inoronga phosphorylation mazinga eAKT uye mTOR, up-regulating LC3-II, inosimudzira kutaura kweBECN1, kuderedza kuwirirana pakati peBECN1 neBCL-2, uye kuwedzera kusimudzira kweFoxO.

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Inhibits oxidative kusagadzikana uye kusingaperi kuzvimba

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Oxidative kusagadzikana uye kusingaperi kuzvimba ndiko kukuru kwemolecular shanduko inoitika mupathophysiology yeCVD. Kuzvimba kunogara kuchishanda kune vakwegura uye injodzi yeCVD. Kugadziriswa kwekutanga kwekuzvimba kunogona kudzivirira kana kunonoka kuitika uye kufambira mberi kweCVD.

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Sesamin ndiyo yakawandisa mafuta-soluble lignin musesame nemafuta uye ine akasiyana emishonga yemishonga, kusanganisira antioxidant uye anti-kuzvimba zviitiko. Sesamine inogona kusimudza-kutonga kutaura kwePPARγ, LXRα uye ABCG1, inokurudzira cholesterol kubuda mu macrophages, uye inodzivirira zvinobudirira kuunganidza cholesterol inokonzerwa neoxidized LDL, nokudaro ichidzivirira kuumbwa kwemasero efuro mumacrophages.

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Lycopene inowanzoitika acyclic carotenoid inowanikwa mumakloroplasts uye chromosomes yemiti, uyewo mu cytoplasm yemamwe eukaryotes akadai seeubacteria uye algae. Epidemiological uchapupu hunoratidza kuti serum lycopene concentration inopesana neCVD ngozi. Lycopene neutralizes reactive oxygen species (ROS), inoderedza macrophage secretion ye-pro-inflammatory cytokines uye metalloproteinases, inhibits smooth muscle cell proliferation, uye inoderedza monocytes. Lycopene inogona kudzivisa mhinduro dzekuvhiringidza nekudzivisa NF-κB activation, uye inogonawo kukanganisa heterobiotic metabolism nekuita nzira yeNrf2 / ARE transcriptional.

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Ginger chirimwa chine monocotyledonous chiri cherudzi Zingiberaceae. Ginger ine zvinhu zvakakosha zvinojekesa ROS, kusanganisira peroxides. Zvese zvinoshandiswa muginger, senge curcumin, gingerol, uye gingerone, zvakaratidza antioxidant basa. [6] - Gingerol inogona kuwedzera superoxide dismutase (SOD) basa nekuita PI3K / AKT nzira yekucherechedza uye kuderedza kugadzirwa kweROS uye kuumbwa kwemalondialdehyde muineonatal rat cardiomyocytes. Uye zvakare, ginger inobvisa yakapfuma mu6-curcumin Inogona kushandisa antioxidant mhedzisiro nekukwevera Nrf2. Zvinonyanya kukosha, iyo vascular protective effects ye ginger inopindirana nenzira dzakasiyana-siyana, kusanganisira kuderedza oxidative kusagadzikana uye kuzvimba, kuwedzera nitric oxide (NO) synthesis, inhibiting vascular smooth muscle cell proliferation, uye kukurudzira autophagy.

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Kuvharidzirwa kwekugadzirisa myocardial

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Kuchinja kwemaitiro kunoitika panguva yekuchembera kwemoyo, kusanganisira kufambira mberi kwepathological myocardial remodeling, inozivikanwa kufanotaura kweCVD. Iyo myocardial remodeling process inoratidzwa nekuchinja kwemuviri uye mamorekuru kunotungamirira ku cardiomyocyte hypertrophy, fibrosis, uye myocardium kuzvimba, pakupedzisira zvichiita kuti kuwedzere kuoma kwe ventricular, kukanganisa kushanda kwemwoyo, uye pakupedzisira mwoyo kusakundikana. Angiotensin II inosimudzira cardiomyocyte hypertrophy uye inokurudzira fibroblast kuwanda uye extracellular matrix protein expression. AMPK inobata basa rinokosha mukugadzirwa kweCVD, uye kushayikwa kwe AMPK kunowedzera hypertrophy yemwoyo uye inoita kuti mwoyo uwedzere kukanganiswa nemoyo.

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Cytokine inoshandura kukura factor β1(TGF-β1) inoita basa rakakosha mukupinza cardiac fibroblasts kuti isiyanise kuita cardiac fibroblasts. FoxO1 chinhu chekunyora chinobatanidzwa muapoptosis, oxidative kusagadzikana uye kusiyanisa masero. TGF-β1 inokurudzira FoxO1 kutaura, uye mu cardiac fibroblasts, TGF-β1 inoderedza FoxO1 phosphorylation, inowedzera FoxO1 nyukireya nzvimbo, inowedzera FoxO1 mapuroteni, uye inokurudzira kusiyanisa kwefibroblasts yemwoyo mufibroblasts yemwoyo.

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Baicalin musanganiswa wechisikigo wakatorwa kubva pamidzi yakaomeswa ye scutellaria baicalensis. Baicalin inhibits pressure overload-induced cardiac fibrosis nekugadzirisa AMPK/TGF-β/Smads nzira dzokuratidza. Izvo zvakanaka zvinokonzerwa nebaicalin zvinosanganisira kurongeka kwe cardiac fibrosis in vivo uye in vitro nekuita AMPK/TGF-β/Smads nzira yekuratidzira. Baicalin inorambidzawo Smad3 uye kutamiswa kwenyukireya kweSmad3 ine transcription co-activator p300, nokudaro ichidzivirira kuvandudzwa kweangiotensin II-mediated cardiac fibrosis.

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Epicatechin ndiyo huru bioactive polyphenol mugirini tii uye ine simba antioxidant. Epicatechin inoderedza angiotensin II uye kushushikana kwakanyanya-mediated cardiac hypertrophy. Epicatechin inhibisa kutaura kweangiotensin II-induced c-Fos uye c-Jun mapuroteni, nokudaro inhibiting AP-1 basa. Mukuwedzera, epicatechin inogona kuvharidzira basa reNF-κB nekuvhara ROS-inotenderera p38 uye JNK nzira dzechiratidzo, uye kuvharidzirwa kweAP-1 kushandiswa kunokonzerwa epicatechin inodzivisa kufambira mberi kwemoyo hypertrophy nekuvhara EGFR transactivation uye zviitiko zvayo zvepasi pasi ERK/PI00mTOR/Ap atrial natriuretic peptide uye B-type sodium Reactivation ye urinary peptides uye inhibition ye cardiac hypertrophy progression. Epicatechin inodzivisawo angiotensin II-induced ROS kugadzirwa uye NADPH oxidase kutaura, nokudaro inhibiting cardiac hypertrophy uye kugadzirisa mwoyo.

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Ongororo iyi inodonongodza mukana wezvigadzirwa zvechisikigo zvekudzivirira uye kurapwa kwechirwere chemoyo. Sezvo huwandu hwehuwandu hwepasi rose zera, zvirwere zvemoyo zvine chekuita nekuchembera zviri kuita dambudziko rakakura rehutano hweveruzhinji. Zvigadzirwa zvechisikigo zvinoshandiswa zvakanyanya mukudzivirira uye kurapwa kwezvirwere zvakasiyana nekuda kwekuita kwavo kwakakosha uye kuchengetedzwa kwakanyanya.

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Zvidzidzo zvakaratidza kuti zvakasiyana-siyana zvezvigadzirwa zvechisikigo zvakadai se resveratrol, berberine, curcumin, lycopene, ginger, baicalein, epicatechin, ellagic acid, honokiol, poria, tanshinone IIA uye marigonin E vane nzira dzakawanda dzekuita mukusimudzira autophagy, inhibiting oxidative inhibiting inhibiting inhibiting kusagadzikana, myocardial inhibiting, kuputika kwemoyo uye kuputika. apoptosis, uye inhibiting ischemia/reperfusion kukuvara. Izvi zvisikwa zvechisikigo zvinotamba basa rekudzivirira kwemoyo nekugadzirisa nzira dzakasiyana-siyana dzechiratidzo, dzakadai semTOR, AMPK, NF-κB, Nrf2, nezvimwewo.

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Mukuwedzera, tsika dzekudya dzine musoro, dzakadai sekuwedzera kudyiwa kwemichero nemiriwo, kunwa zvine mwero yegreen tea, nezvimwewo, zvinogona kubatsira kuderedza njodzi yechirwere chemwoyo. Zvidzidzo zvakawanda zve epidemiological uye miedzo yekiriniki inotsigira maonero aya. Kunyanya, maumbirwo echisikigo akadai semakatekini mugirini tii, lycopene mumadomasi, uye gingerol muginger zvakaratidza zvakakosha kudzivirira kwemoyo.

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Nekudaro, kunyangwe zvigadzirwa zvechisikigo zvine vimbiso yakakura mumunda wekudzivirira uye kutonga kwechirwere chemoyo, kuchine zvimwe zvinonetsa uye zvisingakwanisi. Semuenzaniso, bioavailability yezvimwe zvigadzirwa zvechisikigo yakaderera, maitiro echiito haanzwisisike zvizere, uye kushanda kwekiriniki kunoda kusimbiswa zvakare. Pamusoro pezvo, panogona kunge paine kudyidzana pakati pezvakasiyana zvigadzirwa zvechisikigo, uye optimization yedosi uye nguva yekurapa inodawo kumwe kutsvagisa.