Youdaoplaceholder0 1.1 Yakavanzika nhengo yemhuri yeshuga

Seyo musimboti wesimba rezvipenyu, hurongwa hwekugadzika kwemacarbohydrates hwagara hwakasimbiswa mumabhuku ezvinyorwa: monosaccharides (senge glucose uye fructose), oligosaccharides (senge lactose), uye polysaccharides (senge starch). Nekudaro, iyo chaiyo yemannose iri mu "dual identity" - haingori mutori wechikamu mune simba metabolism asiwo "password character" yekutaurirana kwesero. Mannose inowanikwa zvakanyanya munzvimbo yakasununguka mu pectin layer yemichero yecitrus uye sero madziro e-deep-sea algae. Mumuviri wemunhu, inova iyo mamolecular hwaro hweakakosha emuviri maitiro akadai sekuziva immune uye kunamatira masero kuburikidza neN-link glycosylation shanduko yeglycoproteins.

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Youdaoplaceholder0 1.2 Cognitive Iteration kubva kuUrinary Health kuenda kuCancer Pioneers

Kare kuma1980, nharaunda yezvekurapa yakaona kuti mannose yaigona kudzivirira hutachiona hweurinary turakiti nemakwikwi inhibiting adhesins epathogenic bacteria. Iyi nzira yakapa kukwira kwekutengesa kunopisa kwecranberry inobvisa hutano zvigadzirwa. Asi hazvina kusvika muna 2018 apo chidzidzo chakakosha chakaitwa neCancer Research UK (CRUK) mujenari Nature yakasimudza chidzitiro pakuedza kwayo kwekurwisa gomarara: Mumuenzaniso wembeva wegomarara repancreatic, kuwedzera makumi maviri muzana mannose kumvura yekunwa kwakaderedza kukura kwebundu ne40%, uye kana yasanganiswa nechemotherapy drug gemcitabine, nguva yekupona yakawedzera nguva ye3 mi2. Kuwanikwa uku kwakapidigura fungidziro yakajairika yekuti "shuga dzese dzinosimudzira gomarara".

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Youdaoplaceholder0 Chitsauko 2 Decoding iyo Anti-Cancer Mechanism: Matatu "shuga kukiya" Vhura nzira yehupenyu yeTumor.

Youdaoplaceholder0 2.1 Metabolic Hijacking: "Trojan bhiza" rakavanza seglucose

Iyo "Warburg Effect" yemamota maseru inoita kuti glucose yavo ikwire zvakapetwa kagumi kupfuura yemasero akajairwa. Chikwata cheCRUK chakawana kuburikidza nekabhoni-13 isotope yekuronda tekinoroji iyo mannose inogona kupinza maseru egomarara kuburikidza nemhando imwechete yeglucose transporter (GLUT1/3) ine chimiro chakafanana neicho glucose. Zvisinei, mushure mekupinda, inokurumidza phosphorylated nehexokinase kune mannose-6-phosphate (M6P). Iyi yepakati yemetabolism haigone kupinda munzira yeglycolytic asi pachinzvimbo ichiunganidza mukati mesero kuti iite "metabolic barriers", inotungamira mukuvharwa kweATP synthesis uye kuputika kweiyo reactive oxygen marudzi (ROS), pakupedzisira ichikonzera apoptosis yekenza maseru (Mufananidzo 1).

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Youdaoplaceholder0 2.2 Epigenetic regulation: Kunyorazve "memory code" yekenza maseru.

Muna 2023, timu yekutsvagisa kubva kuFudan University muCell Metabolism yakaratidza zvakare kuti mannose inogona kuita se "epigenome editor". Mune pancreatic ductal adenocarcinoma (PDAC) modhi, kurapwa kwemannose zvakanyanya kuderedza acetylation level yehistone H3K27 saiti, zvichikonzera kudziviswa kwemaitiro ezvinyorwa zveoncogenes MYC neKRAS. Zvinotonyanya kushamisa, izvi zvinoita senge reprogramming mhedzisiro inoenderera - kunyangwe kana kutonga kwezvinodhaka kwamiswa, maseru egomarara anoramba akadzikama, achipa mazano matsva ekurapa kwakanyanya.

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Youdaoplaceholder0 2.3 Kugadziridza hutachiona hwehutachiona: Kubvarura "tsvina-yakavharwa disguise" yePD-L1

Chikwata chimwe chete chakawanikwa muzvidzidzo zvinotevera kuti mannose inogona kutsemura immune system yekupukunyuka yemamota nekukanganisa glycosylation modification yeprogrammed death ligand 1 (PD-L1). Mass spectrometry analysis yakaratidza kuti mannose inhibited the N-glycosylation of asparagine at position 192 yePD-L1 protein, zvichikonzera kusakwanisa kwayo kupeta nemazvo uye kumisa pa membrane yesero. PD-L1, iyo inorasikirwa nekudzivirirwa kwe "shuga shield", yakanyorwa neE3 ubiquitin ligase FBXW41 uye yakasvibiswa neproteasome. Mune mbeva dzemelanoma, kusanganiswa kwemannose uye anti-PD-1 masoja ekudzivirira akawedzera huwandu hwakakwana hwekureruka kwebundu kubva ku28% kusvika 79% (Mufananidzo 2).

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Youdaoplaceholder0 Chitsauko 3 Kubva kuMhuka Models kuenda kuHuman Clinical miedzo: Iyo Minzwa Mugwagwa Wekushandura Mushonga

Youdaoplaceholder0 3.1 Mabhindauko uye Mamiriro ePreclinical research

Mune pancreatic cancer modhi yeCRUK, kunyangwe monotherapy ine mannose yakanonoka kukura bundu, yakatadza kuwana kuregererwa kwakakwana. Zvisinei, kana yakabatanidzwa neFOLFIRINOX chemotherapy regimen, nguva yepakati yekupona kwemakonzo yakawedzerwa kubva pamazuva 42 kusvika kumazuva 98, uye pakanga pasina kuwedzera kwehupfu. Mhedzisiro iyi yakaburitswa mumhando yegomarara rezamu rakapetwa katatu kuMD Anderson Cancer Center: Mannose yakawedzera bundu rekudzvinyirira repaclitaxel kubva pa45% kusvika 72%. Nekudaro, vaongorori vakawanawo kuti ingangoita 15% yemamota haana kupindura mannose. Kumwe kuongorora kwakaratidza kuti aya masero asingaurayiwi nemishonga akanyanya kuratidza mannose-phosphate isomerase (PMI), iyo inogona kushandura M6P kuita fructose-6-phosphate uye kubatanidza kune glycolytic nzira.

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Youdaoplaceholder0 3.2 Mambakwedza akangwarira emiedzo yevanhu

Yekutanga Phase I kiriniki kuyedzwa kwemannose kwakatangwa muna 2022 (NCT05220739) yaisanganisira varwere makumi matatu nevaviri vane mapundu akasimba epamberi. Muboka remazuva ose remazuva ose emuromo we5g mannose, iyo inotenderera bundu DNA (ctDNA) mazinga evarwere 8 yakaderera neanopfuura 50%, pakati peiyo vhoriyamu yematastases echiropa mune imwe pancreatic cancer murwere yakaderera ne31%. Nekudaro, iyo dosi payakakwira kusvika ku10g, manyoka egiredhi III akaitika muvarwere vatatu, zvichiratidza kuti chirongwa chekutonga chinoda kuvandudzwa. Parizvino, intravenous mannose kugadzirira uchishandisa nano-liposome encapsulation tekinoroji iri pasi pekuvandudzwa. Preclinical data inoratidza kuti yavo bundu-yakanangana nekuendesa kugona inosvika 78%, uye muchetura wavo wakadzikira zvakanyanya.

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Youdaoplaceholder0 Chitsauko 4 Shanduko Yemaindasitiri uye Makakatanwa: Iwo Matambudziko Echokwadi eSweet Revolution

Youdaoplaceholder0 4.1 Synthetic biology Inogadzirisa Misa Yekugadzira Puzzle

mannose inotorwa sezvakasikwa inodhura (inenge pakirogiramu)

1200

Zvakaoma kusangana neaponti-cancer dose zvinodiwa (zuva nezuva)

Iyo nzira ndeyekuwedzera kuburitsa kune

Mutengo wacho wakaderera kusvika ku1200), izvo zvakaoma kusangana nezvinodiwa zvekurwisa kenza (10-20g pazuva). Synthetic biology giant GinkgoBioworks yakawedzera goho kusvika pa30g/L ndokudzikisa mutengo kusvika pa50/kg nekugadzirisa mannose-1 - guanosine phosphate transferase (MPG) nzira yeEscherichia coli. Humwe tekinoroji yepamusoro senge CRISPR-Cas9-yakagadziriswa Saccharomyces cerevisiae mabhakitiriya akagadzirwa akakwanisa kuburitsa zvakadzikama-kuchena mannose panguva yekuvirisa kunoramba kuchiita.

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Youdaoplaceholder0 4.2 Mutambo pakati pebhizinesi Hype netsika dzesainzi

Nepfungwa ye "anti-cancer shuga" ichive yakakurumbira, mazana ezvigadzirwa zvehutano zvemannose zvinoti "inobatsira kurapwa kwemamota" zvakabuda papuratifomu yeAmazon, nemibhadharo yemitengo yakakwira zvakapetwa kagumi. Muna 2023, iyo US FDA yakapa tsamba yambiro kumabhizinesi makumi maviri nematatu, ichisimbisa kuti "zvekudya hazvifanirwe kutaura zvine mhedzisiro yekurapa pazvirwere." Masayendisiti anonetsekana kuti kutora madosi akanyanya emannose nekusaona kunogona kukanganisa maruva emukati - kuyedza kwemhuka kwakaratidza kuti kutora kwenguva refu kunotungamirira kukudzikira kwe80% mukuwanda kweFaecalibacterium prausnitzii uye kuwedzera kashanu kweFusobacterium nucleatum. Iyo yekupedzisira inowirirana zvakanyanya nekufambira mberi kwegomarara remukati.

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Youdaoplaceholder0 Chitsauko shanu Remangwana Tarisiro: Iyo yakakura Gungwa reGlyco-based Drugs

Youdaoplaceholder0 5.1 Iyo Glycolic Revolution muPrecision Medicine

Maitiro ekurapa ega ega anobva pane bundu metabolic heterogeneity ari kubuda. Iyo "Mannose Sensitivity Score" (MSS) modhi yakagadziridzwa neBroad Institute muUnited States inogona kufanotaura mhinduro yemukana wevarwere kune mannose nekuona danho rekutaura reGLUT1, chiitiko chehexokinase uye chimiro chePMI mutation mumatumbu. Mukugadzirwa kweChikamu II miedzo yemakiriniki, varwere vepancreatic cancer vane MSS mamakisi ≥75% vachapihwa pekutanga kuti vabatanidzwe kuvandudza mwero wekupindura kurapwa.

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Youdaoplaceholder0 5.2 Muchinjikwa-muganho musanganiswa weshuga Injiniya mishonga

Frontier research haichagutsikane nekushandiswa kumwe chete kwemannose chaiwo. Chikwata cheMIT chakagadzira "mannose-paclitaxel" conjugate, iyo inotora mukana wekutora kwakakwirira kwemannose nemaseru emamota kuti vakwanise kupihwa kwakanangwa kwemishonga yechemotherapy. Mune mhando dzegomarara rezamu, kuuraya bundu kweiyi conjugate kwakapeta katatu kune yechinyakare paclitaxel, uye cardiotoxicity yayo yakaderedzwa ne60%. Kumwe kubudirira kunobva kuShanghai Jiao Tong University: nekubatanidza mannose ne photosensitizer Ce6, "shuga-based photodynamic therapy" iyo inogona kuitwa nepedyo-infrared mwenje yakagadziridzwa, ichiratidza mukana mukudzika bundu ablation.

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Youdaoplaceholder0 Mhedziso: Iyo "inotapira molecule" kunyora zvakare iyo anti-gomarara mitemo.

Rwendo rwekurwisa gomarara remannose ipfunde inopenya inomutswa nekudhumhana kwesainzi yakakosha uye zvinodiwa zvekiriniki. Kubva pakupindira kwemetabolism kusvika kune immune regulation, kubva kumonotherapy kuenda kune yakasanganiswa regimens, iyi shuga morekuru iri kuputsa mutsara wekudzivirira bundu neakawanda-dimensional kurwisa maitiro. Kunyange zvazvo nzira yekutengeserana ichiri kutarisana nematambudziko akadai sekugadzirisa dose, nzira dzekudzivisa zvinodhaka, uye mitemo yemitemo, nharaunda yesainzi ine tariro huru pamusoro payo - sekutaura kwakaita Nobel laureate James Watson, "Chinhu chegomarara is genomic disorder, uye mannoglucose inotidzidzisa kuti kupindira kwemetabolism kunogona kudzoreredza kurongeka." Ichifambiswa nemavhiri maviri emushonga chaiwo uye biology yekugadzira, iyi "shanduko inotapira" inogona kuunza nguva itsva yekurapa cancer.