Vanhu vanopfuura mamiriyoni mazana mashanu pasi rose vane chirwere cheshuga, 90% avo vane Type 2 chirwere cheshuga. Varwere vanofanirwa kudzora kushanduka kweshuga kwehupenyu hwese, uye shuga dzechinyakare (senge sucrose uye fructose) dzakanyorwa sechikafu contraindication nekuti dzinokonzeresa zvakananga kuti shuga yeropa ikwire. Zvisinei, kudiwa kwenyama kwemunhu kwekuravira kutapira kwakaoma kubvisa, uye zvigadzirwa zvinotsiva shuga zvakavapo. Sucralose, sechizvarwa chechina inotapira, yakwezva kutarisisa kune yayo "zero macalorie uye yakanyanya kutapira" zvivakwa 13.

2. Metabolic maitiro uye kuchengetedzwa kwe sucralose
1. Metabolic kubatsirwa
Iyo molecular chimiro che sucralose inogadziriswa neklorini, iyo isina kuodzwa nema enzymes ekudya kwevanhu. Inenge 85% ye sucralose inobudiswa zvakananga kuburikidza nemukati mushure mekudya, uye 15% yakasara inogadziriswa mumakemikari asina chepfu nechiropa uye anobudiswa muweti. Zvidzidzo zvekiriniki zvakasimbisa kuti glycemic index yayo ndeye 0, uye hapana kuwirirana kwakananga ne insulin secretion 12. Semuyenzaniso, 2024 inodzorwa muyedzo neInternational Diabetes Federation (IDF) yakaratidza kusachinja kukuru mukutsanya kweglucose yeropa uye A1C mazinga muvarwere makumi mashanu vane Type 2 chirwere cheshuga vakanwa zvinwiwa zve sucralose kwemazuva makumi matatu akateedzana.

2. Dialectical kuongororwa kwemakakatanwa ekuchengetedza
Kunyangwe tsvagiridzo huru ichitsigira kuchengetedzwa kwayo, kuchine kunetsekana nezve njodzi dzinogona kuitika:

gut microbiota impact : Chidzidzo chemuna 2024 chakabudiswa muNature Microbiology chakaratidza kuti kudyiwa kwezuva nezuva kweinopfuura 15g yesucralose kwakadzivisa kuita kwemaprobiotics akadai sebifidobacterium, zvichikonzera kudzikira kwe20% -30% mugut microbiota siyana 37;
Kudyidzana kwezvinodhaka: Kana yasanganiswa neanticoagulant warfarin, sucralose inogona kuderedza zvinodhaka bioavailability ne12% -15%. 27 inofanira kutorwa maawa maviri akasiyana;
,
kugadzirisa ne-chigadzirwa njodzi ?: kupisa kwekushisa kwepamusoro (> 150 ℃) kunogona kuburitsa huwandu hwechloropropanol ( Chechitatu, zano resainzi rekutsiva shuga
1. Dosage control inogadziriswa kune chiitiko
World Health Organization (WHO) inokurudzira kuti vanhu vane chirwere cheshuga vasadye zvinopfuura 9mg/kg ye sucralose zuva nezuva (inenge 540mg kumunhu mukuru ane 60kg). Mamiriro ezvinhu anofanirwa kusiyaniswa mune zvinoshanda zvekushandisa:

Chinwiwa chekunwa : 300ml yekudya chinwiwa chine 30mg sucralose, inova 5.5% chete yeyakachengeteka muganho 16;
zvakabikwa zvinhu : Sarudza keke inogadzirwa neyakadzikira tembiricha process (2. Integrated diet management
Shuga inotsiva haisi inotsiva iyo yakazara shuga kutonga:

kudya kwakaringana : Sanganisa zviyo (GI iri pasi pe55) uye fiber yekudya (25-30g zuva nezuva) kunonoka kunyura glucose 46;
Kutariswa kweglucose yeropa : Glucose yeropa yakaonekwa maawa maviri mushure mekudya chikafu chinotsiva shuga, uye chengetedzo yega yega mhinduro 58 yakasimbiswa.
4. Maindasitiri maitiro uye dzidzo yevatengi
1. Kugadziriswa kwekunyora kwezvokudya
Iyo yakadzokororwa yeChina's General Rules for Nutrition Labeling yePrepackaged Foods muna 2025 inoda kuti zvikafu zvine sucralose zvimakwe neyambiro "Varwere vane chirwere cheshuga vanofanirwa kudzora huwandu hwekabhohaidhiretsi kudya" uye kuratidza izvo zvinowedzera (mg/100g) 24.

2. Market chaos mhinduro
Muna 2024, General Administration yeMarket Supervision yakawana kuti 18.7% ye "isina shuga" inochengetedza yakawedzera glucose, ichiita se sucralose. Vatengi vanofanirwa kusarudza zvigadzirwa zvine SC certification uye yakazara bvunzo mishumo 78.

5. Future Development Direction
1. Tekinoroji innovation
Muna 2025, Jinhe Industrial yakatanga chirongwa che "directed chlorination" kudzikisa huwandu hwasara hwe sucralose chloropropanol kusvika pa 0.01ppm, uye yakawedzera nguva yekuburitsa intestinal kuburikidza ne microcapsule tekinoroji kuderedza kukanganiswa kwebhakitiriya.

2. Tsvakurudzo yezvokurapa yakavakirwa pauchapupu
Sangano reInternational Diabetes Association rakatanga chirongwa chemakore mashanu che "sugar replacement and metabolic syndrome" yekuongorora kuchengetedzwa kwenguva refu kwe sucralose muvanhu zviuru zana vane chirwere cheshuga.