Uku ongororo ichangobva kuitika, yakabudiswa mupepanhau rine mukurumbira Nutrients muna Kukadzi 2024, naLigia J. Dominguez nevamwe vanobva kuYunivhesiti yePalermo uye University of Enna muItaly. Vakanyatsoongorora hukama pakati pemagesium uye zviratidzo zvekuchembera mumuviri wemunhu, uye vakaona kuti iyi mineral yakajairika inogona kudzikamisa kuchembera, izvo zvinotoshamisa!

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Mazano akakosha:

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1. Magnesium ndiyo yechina yakanyanya kuwanda yemamineral element mumuviri wemunhu uye yakanyatsoenderana nebasa reanopfuura 600 enzymes, inokanganisa zvakasiyana-siyana zvemuviri maitiro.

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2.Magnesium inoshaya zvakanyanya kune vakwegura, iyo inobatana nezvinhu zvakawanda zvakadai semajini, zvakatipoteredza uye mararamiro. Kusakwana magnesium mazinga mumuviri anogona kukurumidza kuchembera.

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3. Zvidzidzo zvakawana kuti magnesium inogona kukanganisa 12 zvinhu zvinokosha zvekukwegura, kusanganisira kusagadzikana kwegenomic, telomere shortening, uye epigenetic shanduko. Magnesium supplementation inotarisirwa kunonoka kuchembera uye kugadzirisa zvinotarisirwa zvehutano.

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Heino chidimbu chakadzama chechinyorwa chekutanga:

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Kushaikwa kweMagnesium kunowedzera 12 kuchembera maitiro

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Kusagadzikana kweGenomic: Magnesium inodzikamisa iyo DNA mbiri helix chimiro uye inobatanidzwa mune dzakasiyana siyana dzekugadzirisa DNA nzira. Kushaikwa kweMagnesium kunogona kukonzera kuunganidzwa kwekukuvara kweDNA, kuwedzera genetic mutations, uye kukurumidza kuchembera.

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Kupfupisa kweTelomere: Telomeres inodzokororwa kutevedzana kumagumo emakromosome anodzivirira genome kubva mukukuvadzwa. Magnesium inodzikamisa magumo.

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Epigenetic shanduko: Epigenetic shanduko mukutaura kwegene inoitika pasina kushandura kutevedzana kweDNA. Magnesium inodzora epigenetic nzira dzakadai seDNA methylation uye histone modification.

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Protein homeostasis imbalance: protein synthesis uye kuora mukati mesero inosvika pakusimba, inonzi protein homeostasis. Magnesium inobatanidzwa mukugadzirisa basa reproteasome uye lysosome, uye kushomeka kwemagnesium kunotungamira mukuunganidzwa kwemapuroteni asina kunyorwa.

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Kuvhiringidzika kwemaonero ehutano: Insulin / IGF-1 uye dzimwe nzira dzechiratidzo dzinoona masero ekudya kwekudya uye kugadzirisa metabolism. Magnesium ndeye cofactor ye insulin receptors uye yakadzika kinases, uye kushomeka kwe magnesium kunokonzera insulin kuramba.

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Mitochondrial dysfunction: Mitochondria mafekitori emagetsi emagetsi, uye DNA yavo nemaketani ekufema zviri panjodzi yekukuvadzwa. Magnesium ndiyo yechipiri yakanyanya kuwanda cation mumitochondria, iyo inobatanidzwa muATP synthesis uye antioxidant, uye kushomeka kwemagnesium kunowedzera kukuvara kwemitochondrial.

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Masero maseru: maseru maseru anomira kupatsanura, avhare zvinokonzeresa, uye anoparadza matishu microenvironment. Magnesium inogona kutadzisa sero kutenderera ichivharira mapuroteni p53 uye p21 uye kunonoka sero senescence.

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Stem cell depletion: Stem masero ane basa rekuvandudza matishu uye kugadzirisa, uye nhamba yavo nebasa zvinodzikira nezera. Magnesium inokanganisa hematopoietic stem cell kusiyanisa, uye kushomeka kwe magnesium kunogona kukurumidza kupera kwe stem cell.

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Kuchinja mukukurukurirana kwe intercellular: cytokines, mahomoni, etc. mediate intercellular signal exchange. Kuchembera kunowedzera kuvharirwa kwezvinhu zvinoputika. Magnesium inodzivisa kuzvimba uye inovandudza kutaurirana kwesero.

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Impaired Autophagy: Autophagy inzira yakakosha yekuti maseru aderedze mapuroteni akakuvadzwa uye organelles. Magnesium inochengetedza autophagy basa nekugadzirisa basa re autophagy rine hukama majini uye kinases.

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Intestinal flora disorder: intestinal flora inobatanidzwa mune zvinovaka muviri metabolism uye mutemo wekudzivirira zvirwere, uye kusaenzana kwehutachiona hunoenderana nekukwegura. Magnesium inodzora gut flora uye inovandudza hutano hwevaenzi.

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Kuzvimba kusingaperi: Kuchembera kunoperekedzwa nekuzvimba kwakaderera-giredhi mumuviri wese, ndiko kuti, "kuchembera kuchembera". Kushaikwa kweMagnesium kunokonzera kuwandisa kwekuita kweanopisa kusaina nzira dzakadai seNF-κB uye kunowedzera mhinduro yekuzvimba.

Maererano nenhamba yakawanda yezvidzidzo zvepidemiological uye miedzo yakarongeka yakarongeka, kuwedzera kwekudya kwe magnesium kudya uye kuwedzera magesium kugadzirira kunogona kuderedza zera-ane hukama kusingaperi kuputika, insulin kudzivisa, chirwere chemwoyo, nezvimwewo.

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Kunyange zvazvo magnesium isina ngozi, vanhu vane renal insuffience vanofanira kungwarira, uye mishonga yakawanda yemishonga inogona kukonzera manyoka. Vakuru vakwegura vanofanira kuisa mberi kuwana magnesium yakakwana kubva pakudya kwavo, zvakadai semashizha emashizha emashizha, zviyo zvakakwana, nzungu, etc. Kana zvichidiwa, tevera mazano echiremba kuti uwedzere magnesium, uye ugare uchicherechedza ropa re magnesium concentration.

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Humbowo hwakadzama hwekuyedza uye data yekiriniki:

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Humbowo hwekuyedza magnesium uye genomic kugadzikana DNA ndiyo genetic zvinhu zvehupenyu, uye kugadzikana kwayo ndiyo hwaro hwekuita kwese kushanda kwemasero. Chidzidzo ichi chakawana kuti kune ma magnesium ions pakati pe50% yema base pairs muDNA double helix chimiro, iyo inoita basa mukudzikamisa chimiro. Mune modhi zvipenyu zvakaita seEscherichia coli uye mbiriso, yakaderera magnesium nharaunda inokonzeresa kuwedzera kukuru kweDNA kudzokorodza kukanganisa mitengo. Hunhu fibroblast yetsika kuyedza yakasimbisawo kuti yakaderera magnesium inogona kukonzera kukurumidza kupfupisa telomere uye kumusoro-mutemo weDNA kukuvadza mhinduro gene kutaura. Kuedza kwemhuka kwakaratidza kuti iyo antioxidant system yekudzivirira yakakuvadzwa munyama yechiropa ye magnesium isina makonzo, uye nhanho ye8-hydroxy-deoxyguanosine, chiratidzo cheDNA oxidative kukuvara, yakawedzera. Chidzidzo mumakonzo chakawana kuti kunwa mvura ine magnesium-yakawanda kunorebesa telomere kureba uye kwakaderedza kukuvara kweDNA. Mhedzisiro iyi inoratidza kuti magnesium yakakosha pakuchengetedza genomic kugadzikana.

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Muzvidzidzo zvehuwandu, serum kana erythrocyte magnesium mazinga akave akabatana zvisina kunaka neakasiyana zviratidzo zvekusagadzikana kwegenomic, senge micronucleus frequency, mazinga eDNA kukanganisa zvigadzirwa 8-hydroxy-deoxyguanosine, uye telomere kureba. Chidzidzo chemuchinjika chevanhu vakuru vane hutano vanosvika mazana maviri vakawana kuti avo vane masero matsvuku eropa magesium mazinga aive neperipheral blood lymphocyte telomere urefu hwaive, paavhareji, 11.5% ipfupi pane avo vane mazinga epamusoro emagnesium. Imwezve cohort yekuongorora ye1800 yepakati-yepakati nevarume vakuru vane makore 45-74 makore akateedzerwa kwemakore 5 akawana kuti kudya kwemagesium kudya kwakabatana zvakanyanya nehuwandu hwekukuvadzwa kweDNA mumaperipheral blood lymphocytes pakutanga, uye kuti kuwedzera kwega kwega mukutora magnesium ye100mg / zuva kwakaderedza dhigirii re5% kukuvara kweDNA mushure me5%. Izvi zvinoratidza kuti magnesium supplementation muvanhu inogona kubatsirawo kuchengetedza genomic kugadzikana.

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Chechipiri, hukama pakati pe magnesium uye telomerase chiitiko uye kuchembera kwesero Telomeres zvimiro zvakakosha pamagumo ekromosomes, anoumbwa neTTAGGG inodzokorora uye telomere-inosunga mapuroteni, anodzivirira makromosomes kubva mukuora panguva yekuparadzaniswa kwesero. Asi mumasero emunhu, kureba kwetelomere kunopfupisa ne50 kusvika ku100 base pairs pachikamu, uye kana kupfupika kwasvika paukoshi hwakakosha, sero rinopinda muchimiro chesenescence. Telomerase iri ribonucleoprotease inorebesa kutevedzana kwetelomere, asi kazhinji isingataurwi zvakanaka kana kusaratidzwa mumasero evakuru.

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Mu mouse embryonic fibroblasts (MEF), yakaderera magnesium yepakati yakaderera telomerase chiitiko neinopfuura 50% uye yakaratidza cellular senescence maficha, akadai sekuwedzera β-galactosidase chiitiko uye up-regulated kutaura kwe cell cycle inhibitors p16 uye p21. Aya phenotypes ekuchembera anogona kudzoserwa shure mushure mekurapa nemagnesium kana telomerase activators. Migumisiro yakafanana yakaonekwa mumasero evanhu endothelial uye fibroblasts. Molecular mechanism zvidzidzo zvakawana kuti magnesium inogona kudzora urefu hwetelomere nekukanganisa kutaura uye kuiswa kwemamwe mapuroteni anokosha mu telomere yakaoma, yakadai seTRF1 uye TRF2. Pamusoro pezvo, magnesium inogona zvakare kumisa nzira dzekusaina dzakadai seAKT neERK, uye inhibit cell cycle inhibitors senge p53 neRb, nekudaro kunonoka kuchembera kwesero.

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Zvidzidzo zvekiriniki zvakare zvinotsigira kubatana pakati pe magnesium uye cellular senescence. Muvanhu vanopfuura zana vane hutano vakwegura, serum magnesium mazinga akabatanidzwa zvakanaka neT lymphocyte kuwedzera uye zvakashata zvakabatanidzwa ne plasma p16 mazinga. Imwe ongororo yaisanganisira 250 vanhu vakura munharaunda, uye yakawana kuti baseline serum magnesium mazinga aienderana zvakanyanya nekuchinja kwemaitiro ekuchembera zviratidzo zvakadai sekunzwa chikumbaridzo, simba rekubata, uye kukurumidza kufamba, zvichiratidza kuti chimiro chemagnesium chinogona kukanganisa kuchembera kwese kwemuviri. Chidzidzo cheboka chevanhu vanopfuura 2,000 vane makore anopfuura makumi manomwe vakaenzanisa mazinga akasiyana-siyana e serum magnesium ane ngozi yemakore gumi yekufa uye akawana kuti boka rine mazinga akaderera e magnesium aiva ne 2.2 nguva huru yekufa kupfuura boka rine mazinga akakwirira. Kunyangwe izvi zvidzidzo zvekutarisa zvisingakwanisi kuratidza zvakananga chikonzero nemhedzisiro, zvinotsigira hukama hwakasimba pakati pemagnesium nekuchembera kubva pamaonero ehuwandu.

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Basa re magnesium mune insulin kusaina nzira Insulin ndiyo musimboti wekudzora mahormone eropa remunhu glucose homeostasis. Mushure mokunge insulini inosunga kune receptor yayo, inokonzera self-phosphorylation ye receptor, uye inoshandisa mutsara wepasi pasi protein kinases yakadai sePI3K uye AKT, uye pakupedzisira inogadzirisa kutaura kwemajini ane chokuita neglucose metabolism. Kuedza kwakawanda kwakaratidza kuti magnesium inoita basa rakakosha munenge nhanho imwe neimwe yekusaina insulin. 1. Mumasero e-islet beta, magnesium inoumba MgATP yakaoma neATP kuti iite chikamu muhutano hwese hwe insulin synthesis, kugadzirisa uye kuvhara. Mune mbeva uye rat beta cell mitsara, yakaderera-magnesium yepakati yakaderedza glucose-inosimudzira insulin secretion neinopfuura 70%. 2. Mune insulini inotarirwa masero, tyrosine kinase basa re insulin receptors rinoenderana ne magnesium ions, uye kushayikwa kwe magnesium kunotungamirira ku insulin receptor phosphorylation uye kudzika kwechiratidzo chekudzivirira kwechiratidzo chekudzivirira, zvichiita kuti insulini irambe. Mu 3T3-L1 adipocytes uye L6 skeletal muscle masero, pasi-magnesium medium yakaderedza insulini-inosimudzira glucose kutora ne 40% kusvika 60%. 3. Magnesium inobatanidzwawo mukugadzirisa insulin senitivity kuburikidza nekudzivisa mapuroteni phosphatase, kugadzirisa mazwi e integrins, kukanganisa GLUT4 basa rekutakura uye mamwe maitiro. Zvimwe zviedzo zvemhuka zvakaratidza kuti chiyero chekudya chekuwedzera che magnesium chinovandudza insulin kuramba mukufutisa uye mhando 2 chirwere cheshuga.

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Zvidzidzo zveEpidemiological zvakare zvinotsigira hukama hwepedyo pakati pemagnesium uye glucose metabolism. The US Nurses 'Health Study, iyo yaisanganisira vakadzi vangangosvika zviuru makumi manomwe vezera remakumi mana neshanu yakateverwa kwemakore anopfuura makumi maviri, yakawana kuti avo vari padanho repamusoro rekudya magnesium vane njodzi yakaderera ye27% yekuva nechirwere cheshuga cherudzi rwechipiri pane avo vari pasi quintile. Meta-analysis ye25 cohort zvidzidzo zvinosanganisira vangangosvika miriyoni vatori vechikamu yakaratidza kuti yega yega 100mg / zuva kuwedzera kwekudya magnesium kudya kwakabatana ne8% kusvika 13% kuderedzwa kwenjodzi yerudzi rwechipiri chirwere cheshuga. Mune vanhu vane chirwere cheshuga chiripo, yakaderedzwa serum magnesium mazinga zvakare ane hukama nekukura kwechirwere uye matambudziko. Chidzidzo chevarwere vanopfuura mazana matatu vane chirwere cheshuga chechipiri chakawana kuti serum magnesium mazinga aive akaderera zvakanyanya kune avo vane chirwere chemoyo chemoyo pane avo vane chirwere cheshuga chete. Mukupedzisa, nhamba huru yezvidzidzo zvakaratidza kuti magnesium supplementation inogona kunonoka kukwegura nekuvandudza insulin kuramba.

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4. Magnesium inoshaya uye mitochondrial dysfunction Mitochondria ndiyo nzvimbo huru dzemagetsi emagetsi emagetsi uye reactive oxygen marudzi (ROS) kugadzirwa. Munguva yekuchembera, kushanda zvakanaka kwemitochondrial electron cheni yekutakura kunodzikira uye kugadzirwa kweROS kunowedzera, zvichikonzera mtDNA mutation, membrane lipid peroxidation uye kumwe kukuvadza, kugadzira kutenderera kwakashata uye kukurumidza kuchembera kwesero. Zvidzidzo zvakawana kuti chikamu chimwe muzvitatu che magnesium mumuviri chakachengetwa mumitochondria, iyo yakakosha pakuchengetedza mitochondrial chimiro uye basa. Mumbeva yechiropa mitochondria, mapfumbamwe egumi nematatu eadenosine triphosphatase anoda magnesium se cofactor. Mune mbeva myocardial mitochondria, yakaderera magnesium inogona kuderedza zvakanyanya zviitiko zvema enzymes mu tricarboxylic acid kutenderera, senge isocitrate dehydrogenase uye α-ketoglutarate dehydrogenase. Mune rat chiropa mitochondria, kushomeka kwemagnesium kunogona kuderedza ATP synthesis rate neanopfuura makumi matanhatu muzana, kuderedza kufema kudzora mwero, uye kuwedzera ROS kugadzirwa, zvichikonzera kuwedzera mtDNA kukuvara uye mutation rate. Magnesium supplementation inogona kudzosera iyi mitochondrial dysfunction. Mune skeletal tsandanyama maseru uye cardiomyocytes, yakaderera magnesium inogona depolarize mitochondrial membrane kugona, kuitisa kuvhurwa kwemitochondrial permeability transition pore (mPTP), kukonzeresa kuburitswa kwe cytochrome C, uye pakupedzisira kutungamirira kuapoptosis. Mumaseru emuumbilical vein endothelial masero, yakaderera magnesium inokonzera nhamba huru yemitochondrial ROS ne activating protein kinase C, zvichiita kuti endothelial dysfunction. Ongororo yevarwere vanopfuura zana vane metabolic syndrome yakawana kuti serum magnesium mazinga aive akanaka akabatana nemitochondrial kufema basa uye yakabatana zvisina kunaka nemitochondrial ROS mazinga. Muchidimbu, humbowo huri pamusoro hunoratidza kuti magnesium chinhu chakakosha pakuchengetedza mitochondrial homeostasis, uye kusagadzikana kwemitochondrial ndeimwe yenzira dzakakosha dzekuchembera.

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Chechishanu, basa rekutonga remagesium pakuzvimba kusingaperi uye kuchembera kwedziviriro Kuzvimba kwakaderera-giredhi chimwe chinhu chakakosha chekuchembera. Zvidzidzo zvakawana kuti mazinga ezvipembenene zvakadai seIL-6 uye TNF-α muvanhu vakwegura inowedzera zvakanyanya, nepo mazinga e-anti-inflammatory cytokines akadai seIL-10 anoderera, uye izvi zvisingaperi zvinopisa zvinokonzerwa nekukwegura zvinozivikanwa se "inflammaging". Kuzvimba kuchembera kunogona kukonzera kukuvadzwa kwematishu uye kusaenzana kwemuviri, inova iyo pathological hwaro hwezvirwere zvakawanda zvisingaperi. Zvidzidzo zvekuyedza zvakaratidza kuti kushomeka kwe magnesium kunogona kukonzera kuzvimba kupindura uye kusagadzikana kwe immune. Mune mbeva macrophage tsika, yakaderera magnesium inogona kusimudza-kutonga NF-κB basa uye kukurudzira kuburitswa kwezvinhu zvakasiyana-siyana zvinopisa. Mubronchial epithelial masero emakonzo, secretion yeIL-6 uye IL-8 inogona kuwedzerwa ne2 kusvika ku3 nguva neLPS kukurudzira pasi peyakaderera magnesium nharaunda. Mumasero emunhu endothelial, yakaderera magnesium inogona kumisa iyo p38 MAPK yekusaina nzira, inoita kuti kutaura kwe intercellular adhesion molecules kuve kumusoro-kudzorwa, uye kuwedzera mhinduro yekuzvimba. Mune makonzo asina kukwana magnesium, mazinga eTNF-α, CRP uye interleukin mukutenderera uye matishu akawedzera zvakanyanya, mitezo yemuviri yaive atrophy, nhamba uye basa reT uye B lymphocytes zvakaderedzwa, uye immunosuppression yakawedzera. Magnesium supplementation inogona kunyatsogadzirisa izvi zvinoputika uye zvirwere zvekudzivirira zvirwere. Zvidzidzo zvekiriniki zvakawanawo kuti yakaderera magnesium ine hukama nekusingaperi kuzvimba. Chidzidzo chemuchinjiko chevanhu vakuru vanopfuura zviuru zvishanu muUnited States chakawana kuti serum magnesium concentration yakabatana zvakanyanya neCRP uye chena masero eropa, uye CRP neIL-6 mazinga muyakaderera quartile yemazinga emagnesium aive makumi matanhatu% uye 40% akakwira kupfuura ayo ari muquartile yepamusoro. Hukama hwakatosimba muvanhu vakafutisa. Imwe ongororo ye3,200 vanhu vanopfuura makore makumi matanhatu neshanu yakawana kuti serum magnesium mazinga aive akanaka akabatana newhite blood cell telomere kureba uye yakabatana zvisina kunaka neCRP uye D-dimer mazinga. Meta-analysis ye25 randomized controlled trials ine saizi yese yemuenzaniso yevanhu vanopfuura 2,000 yakaratidza kuti oral magnesium supplementation yakaderedza serum CRP mazinga neavhareji ye22%, TNF-α ne15%, uye IL-6 ne18%. Naizvozvo, magnesium supplementation inogona kunonoka kukwegura kwemuviri kuburikidza ne-anti-inflammatory effects.

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Hukama hwekutonga pakati pe magnesium uye autophagy Autophagy inzira yakakosha yekushatisa sero uye kubviswa kweakakuvadzwa mapuroteni uye organelles, uye yakakosha pakuchengetedza iyo homeostasis yenharaunda cellular. Zvidzidzo zvakaratidza kuti autophagy basa rinodzikira zvishoma nezvishoma panguva yekuchembera, uye kukanganisa mu autophagy kunogona kukonzera protein aggregation, mitochondrial dysfunction, nezvimwewo, uye kukurumidza kuchembera kwesero. Magnesium, semutumwa wechipiri, inobatanidzwa mukugadzirisa kutangwa uye maitiro e autophagy. Mune mbiriso, kushomeka kwe magnesium kunodzivirira kutaura kweautophagy ane hukama majini Atg1 uye Atg13 nekuita TORC1 nzira yekusaina. Mumasero emammalian, nzvimbo yakaderera ye magnesium inogona kudzivisa basa reULK1, Beclin1 uye mamwe mapuroteni ekutanga autophagy, uye kuvhara kuumbwa kwe autophagosomes. Mune embryonic masero eitsvo, magnesium ion chelating agent EDTA inogona kutadzisa autophagy kuyerera. In vitro zviedzo zvakaratidza kuti physiological concentrations ye magnesium ion inogona kusunga zvakananga uye kumisa Atg4, proteolytic enzyme inodiwa kuti autophagosome maturation. Zvidzidzo zvemhuka zvakawanawo kuti mwero wekudya wekuwedzera we magnesium unogona kuderedza autophagy kusagadzikana mueuroni uye cardiomyocytes, kunatsiridza cognitive basa uye yemwoyo systolic basa. Kunyangwe paine kushomeka kwehumbowo hwekiriniki hwakananga, zvimwe zvidzidzo zvekutarisa zvinoratidza kuwirirana pakati pemagnesium uye autophagy. Magnesium mazinga ainyatsoenderana nekutaura kweautophagy mamaki Atg5 uye Beclin1 muuropi tishu uye peripheral ropa mononuclear masero evarwere vane chirwere cheAlzheimer. Mune varwere vane Type 2 chirwere cheshuga, serum magnesium concentration inowirirana zvakanyanya nekutaura mazinga e autophagy ane hukama genes LC3 uye p62. Mukupedzisa, magnesium inogona kuita basa rakakosha mukuramba kuchembera nekudzora autophagy. Asi maitiro ayo chaiwo anoda kuramba achidzidza.

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7. Kudyidzana pakati peMagnesium uye intestinal flora Intestinal flora inokosha "nhengo" mumuviri wemunhu, iyo inobata basa risingagoneki muhutano hwemetabolism, mutemo wekudzivirira zvirwere, neuroendocrine nezvimwe zvinhu. Tsvagiridzo ichangoburwa yakawana kuti shanduko mukuumbwa uye kushanda kwegut microbiota zvine hukama zvakanyanya nekuchembera. Semuenzaniso, chikamu che firmicutes uye Bacteroides mumatumbo evanhu vakwegura yakaderera zvikuru, asi chikamu chezvirwere zvinokonzerwa nehutachiona zvakadai se enterococcus uye Staphylococcus chakawedzera. Uku kusaenzana kwemaruva kunogona kukonzera kukuvadzwa kwechivharo chemukati, kukurudzira kuburitswa kwezvinhu zvinoputika, uye kuwedzera kuzvimba kusingaperi mumuviri wese.

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Sechikamu chakakosha chemuviri mudumbu, magnesium inogona kukanganisa kuumbwa kwemaruva kuburikidza nemhando dzakasiyana-siyana. Mune mbeva dzisina utachiona, mvura yekunwa yakapfuma mu magnesium inogona kuwedzera zvakanyanya huwandu hwehutachiona hunobatsira senge bifidobacterium uye Bacteroides, uye kuderedza intestinal pH kukosha. Mumuenzaniso wembeva wecolitis, magnesium supplementation yakaderedza kukanganiswa kwemaruva emudumbu uye yakavharira NF-κB activation munzira yekuzvimba chiratidzo. Mukuedza kwevanhu vane hutano, chikamu chebifidobacteria mutsvina chakawedzera mushure memavhiki masere ekugadzirisa magnesium, uye mazinga e lipopolysaccharide, D-lactic acid uye mamwe mabhakitiriya metabolites akaderera. Zvimwe zvidzidzo zvepreclinical zvakawanawo kuti kushomeka kwemagnesium kunogona kukanganisa matumbu akasimba, kuwedzera permeability, uye kugadzira mamiriro ekuchinjisa enterogenic endotoxins.

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Magnesium inogonawo kukanganisa kuchembera kwemuenzi nekugadzirisa bhakitiriya metabolism. Semuenzaniso, magnesium inokurudzira kugadzirwa kwepfupi-chain mafuta acids akadai seBifidobacterium, iyo inomutsa G-protein-coupled receptor GPR43, iyo inhibisa kuneta kunoenderana nekuzvimba uye insulin kuramba. Uye zvakare, magnesium inogona zvakare kukanganisa bile acid uye tryptophan metabolism, uye kusagadzikana kweidzi nzira mbiri kune hukama zvakanyanya nekuchembera uye neurodegenerative chirwere. Mukupedzisa, magnesium inotarisirwa kuve nzira nyowani yekunonotsa kuchembera nekugadzirisa maruva emudumbu uye kudzora bhakitiriya-gut-brain axis, asi mhedzisiro yaro yenguva refu inoda kusimbiswa nevanotarisirwa zvidzidzo zveboka.

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Muchidimbu, huwandu hukuru hwekuyedza uye epidemiological humbowo hunoratidza kuti magnesium chinhu chakakosha kurwisa kuchembera uye kukurudzira hutano uye hupenyu hurefu. Inobatanidzwa mukugadzirisa kukwegura kuburikidza nenzira dzinotevera:

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Kunyange zvazvo migumisiro ye magnesium supplementation pahupenyu hwevanhu ikozvino isinganzwisisiki, humbowo husina kunanga hunoratidza kuti magnesium inogona kubatsira kunonoka kukwegura kwakawanda phenotypes uye kuvandudza tarisiro yehutano. Mune ramangwana, zvidzidzo zveboka revanhu pamwe nemiedzo inodzorwa zvisina kurongwa inodiwa kuti iwedzere kujekesa mhedzisiro yekurwisa kuchembera kwemagnesium uye hukama hwayo hwedoro-effect, kuitira kupa humbowo-hwakavakirwa humbowo hwekugadzira nzira dzekuwedzera magnesium. Uye zvakare, iyo magnesium yekudya kwekudya uye kudiwa kwevanhu vakasiyana hakuna kufanana, saka kuumbwa kwega yega magnesium yekuwedzera chirongwa idambudziko rekukurumidzira kugadziriswa. Zvinotendwa kuti nekuvandudzwa kwemushonga wekuchembera uye kudya kunovaka muviri, tinozopedzisira tafumura zvese zvakavanzika zveiyi mashiripiti element magnesium, uye toishandisa kurwisa kuchembera uye kuona kurota kwehupenyu hurefu.

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