HMB ndeyepakati metabolite yemunhu yakakosha amino acid leucine, uye muviri wemunhu unogona kuburitsa shoma shoma yeHMB pachayo. Muzvokudya zvakajairika, muviri wemunhu unobereka anenge 300 kusvika 400 mg pazuva, iyo 90% inobva ku catabolism ye leucine. HMB inogona kushandiswa kukurudzira kukura kwemhasuru, kuwedzera kusadzivirirwa, kuderedza cholesterol uye yakaderera density lipoprotein mazinga mumuviri kuderedza kuitika kwechirwere chemoyo uye chirwere chemoyo, asiwo kuwedzera kugona kwemuviri kugadzirisa nitrogen, kuchengetedza mazinga eprotein mumuviri, uye kudzivirira kuparara kwemisumbu muvarwere vakarara kana vakaoma mitezo. Mumakore achangopfuura, nekuti inogona kuderedza kukuvadzwa kwetsandanyama mushure mekuita maekisesaizi, kugadzirisa tsandanyama fiber, kuwedzera mhasuru simba uye kupisa mafuta emuviri, yave chinhu chenyeredzi muzvigadzirwa zvemitambo zvinovaka muviri. Pamusoro pezvo, HMB yakaratidzirwa nekiriniki kuti ikurumidze kupora maronda uye kumisa kuzvimba. Zvidzidzo zvakaratidza kuti Ca HMB inogona kukurumidzira mapuroteni synthesis uye kunonoka kudyiwa kweprotein. Ca HMB yakasanganiswa ne glutamine uye arginine inogona kuvandudza yakashata nitrogen chiyero chevarwere uye kuita basa rakanaka mukupora kubva mukushungurudzika nekuvhiyiwa.

Muna 2011, yaimbova Ministry of Health yeChina yakazivisa kubvumirwa kwe β-hydroxy-β-methylbutyrate calcium (Ca HMB) sechikafu chitsva chekushandisa, kushandiswa kwekudya kwemitambo yekudya, chikafu chakakosha chekurapa chikafu, iyo yakakurudzirwa mari ndeye ≤3 gramu / zuva. Muna 2017, National Health and Family Planning Commission yakazivisa kuwedzera kwechikamu chekushandisa cheCa HMB kubva pamanyorerwo maviri ekutanga kusvika papfumbamwe, uye yakaraira masangano ekuongorora njodzi kuti aite ongororo dzekuchengetedza. Kushandiswa kweCa HMB kwakawedzerwa kuti kusanganise zvinwiwa, mukaka uye zvigadzirwa zvemukaka, cocoa zvigadzirwa, chokoreti nechokoreti zvigadzirwa, zvihwitsi, zvakabikwa, uye chikafu chakakosha chekudya, uye huwandu hwakakurudzirwa hwaive huchiri ≤3 g / zuva, iyo isingapfuure chiyero chevanhu vanozvipira. Ca HMB yakazivikanwa seGRAS neUS Chikafu neDrug Administration muna 1995 uye inoshandiswa mukurapa chikafu chekudya uye chikafu chakakosha. Mumakore makumi maviri apfuura, Ca HMB yakashandiswa zvakanyanya muzvigadzirwa zvemukaka, zvigadzirwa zvechokoreti, zvinwiwa, mabhawa emagetsi uye zvimwe zvekudya mumusika weUS. Ca HMB chikafu chekudya chinobvumirwa nemirairo yeJapan, iyo inogona kuwedzerwa munzvimbo dzakawanda dzakadai sechikafu chekudya, chikafu chemitambo chekudya, kuderedza uremu, chikafu chekunaka, nezvimwewo. Inogonawo kushandiswa sechinhu chinoshanda muzvokudya zvinowedzera zvakadai se capsules, mapiritsi, zvinwiwa zvakasimba. Kune vagadziri uye ma pharmacy, Ca HMB parizvino ndeimwe yeanonyanya kufarirwa hutano zvigadzirwa pamusika weJapan.