1, Core mechanism

Targeted bhakitiriya metabolite glyoxylate

Mabhakitiriya anodzivirira zvinodhaka anosimudzira kutaura kweglyoxylate munzvimbo dzisina kudya kunovaka muviri, izvo zvinogadziridza maitiro epigenetic, kuderedza mhinduro dzemuviri, uye kubatsira mabhakitiriya kurarama pasi pekumanikidzwa kwemishonga inorwisa mabhakitiriya nekudzivisa basa reDNA demethylase (TET2) mumasero anotambira.

Vitamin C inomutsa TET2 enzyme basa

Vitamin C, seyakasikwa activator yeTET2, inogona kurwisa inhibitory mhedzisiro ye glyoxylate pane inodzivirira immune, kudzoreredza DNA demethylation basa, uye kutangazve immune system.

Kuvhiringidza nzira ye "kufa kwenhema" kwebhakitiriya

Acetaldehyde panguva imwe chete inomisikidza nzira yekuzvidzivirira yebhakitiriya, ichigadzira vanoramba vachinzvenga kuuraya kwemishonga inorwisa mabhakitiriya. Vhitamini C yakasanganiswa nemishonga inorwisa mabhakitiriya inogona kutyora iyi metabolic adaptation uye kuderedza zvakanyanya kurongeka kwebhakitiriya.

2. Humbowo hwekuyedza

Kusimbiswa kwemhando yemhuka: Mumuenzaniso wehutachiona hwembeva, kusanganiswa kwevhitamini C nemishonga inorwisa mabhakitiriya yakawedzera chiyero chekurarama ne60%, yakaderedza bhakitiriya mumatishu ne80%, uye yakadzikira mazinga ezvimba ne50%.

Synergistic effect: Vitamin C inosimudzira nzira yekuratidzira yeinterferon (IFN), inosimbisa kugona kwesero redziviriro yekubvisa mabhakitiriya asingaurayiwi nemishonga, uye inhibits STAT1 dephosphorylation, ichirebesa anti-tumor immune reaction.

3, Clinical application inogona

Kukunda dambudziko rekuramba zvinodhaka: Iri zano rinopa kurapa kutsva kusingaenderane nemishonga inorwisa mabhakitiriya kune hutachiona husingarambike nemishonga seSalmonella neMycobacterium tuberculosis, kunyanya kuvarwere vane hutachiona hunoramba huchidzokororwa kana mishonga isingashande.

Urongwa hwekurapa hwakareruka: Vitamin C, semushonga wakachengeteka uye usingadhuri, unogona kushandiswa pamwe chete nemishonga inorwisa mabhakitiriya iripo kuderedza chiyero chemishonga uye kuderedza mhedzisiro.

Kudzivirirwa kwekuwedzera kukosha: Kudya kwakakwana kwemicronutrients (yakadai sevhitamini C) kunogona kuderedza zvisina kunanga njodzi yekutapurirwa kwejene remishonga nekuchengetedza gut microbiota chiyero.

4. Nhungamiro dzekutsvaga mune ramangwana

Ongorora iyo synergistic mhedzisiro uye yakakwana dosage musanganiswa wevhitamini C nemamwe maantibioti akadai se beta lactams uye quinolones.

Ongorora mhedzisiro yenguva refu yevhitamini C yekuwedzera pakushanduka kwehuwandu hwehutachiona husingarapike nemishonga.

Kugadzira novel antibacterial mishonga yakanangana neiyo glyoxylic acid-TET2 axis