Lycopene (LYC), carotenoid, i-fat-soluble pigment, inonyanya kuwanikwa mumadomasi, watermelon, grapefruit nemimwe michero, ndiyo pigment huru mumadomasi akaibva. Lycopene ine hutano hwakasiyana-siyana hunobatsira, kusanganisira kuchenesa mahara radicals, kurerutsa kuzvimba, kudzora glucose uye lipid metabolism, uye neuroprotective mhedzisiro.

Munguva ichangopfuura, Vatsvakurudzi vanobva kuShanxi Medical University vakabudisa pepa mumagazini Redox Biology rine musoro unoti "Lycopene inoderedza kukanganisa kwekuziva kwezera kuburikidza nekuita chiropa-brain. Pepa rekutsvakurudza re fibroblast growth factor-21 signing ".

Zvidzidzo zvakaratidza kuti kuwedzera ne lycopene kwemwedzi ye3 kunogona kunonoka kuchembera kwehuropi mumakonzo uye kuderedza kukuvara kwekuziva kwezera, uye lycopene inovandudza neuronal degeneration, mitochondrial dysfunction, synaptic damage, uye inosimudzira synaptic vesicle fusion mukuchembera makonzo.

Mukuwedzera, lycopene yakagadziriswa chiropa-brain axis FGF21 inoratidzira mumakonzo akwegura, nokudaro ichikurudzira kusunungurwa kwemaurotransmitters nekuwedzera mitochondrial ATP mazinga uye kuwedzera synaptic vesicular fusion. Izvi zvinoratidza kuti FGF21 inogona kunge iri chinangwa chekurapa muhutano hwekupindira mazano kunonoka kuchembera kwehuropi nekuvandudza kukanganiswa kwekuziva kwezera.

Mukuchembera, kuchembera kwehuropi, kusagadzikana kwemitochondrial chimwe chezvinhu zvinonyanya kukosha, vatsvakurudzi vakawana kuti lycopene supplementation inogona kuvandudza mitochondrial morphological damage, uye kudzorera chiyero chemitochondrial electron transport chain complex inokonzerwa nekukwegura, kukurudzira kugadzirwa kweATP, zvichiratidza kuti lycopene ine simba rekudzivirira pane mito.

Pakupedzisira, vatsvakurudzi vakaitawo zviedzo zve vitro uye vakawana kuti lycopene yakasimbisa kukwanisa kwemasero echiropa kutsigira neuroni, kusanganisira kuvandudza kukwegura kwesero, kuwedzera mitochondrial basa, uye kuwedzera neuron axon kureba.

Kutorwa pamwe chete, zvigumisiro zvinoratidza kuti lycopene supplementation inogona kunonoka kukwegura kwehuropi uye kudzivirira kukanganisa kwehutano hwezera mumakonzo, muchidimbu nokuti lycopene inoshandisa hepato-brain axis FGF21 kuisa chiratidzo, zvichiratidza kuti FGF21 inogona kunge iri chinangwa chekurapa muhutano hwehutano hwekuvandudza zera rekugadzirisa zvirwere zvinokonzerwa neurogenerative cognitive neurogeneration.