Citicolineyakashandiswa zvakanyanya mumakiriniki ekudzidzira, kunyanya pakurapa kweurological sequelae inokonzerwa nekukuvara kwecraniocerebral kana njodzi yecerebrovascular, uye yakawana kushandiswa kutsva mumakiriniki maitiro. Kurapa kwayo mucerebral hemorrhage, chirwere cheParkinson, glaucoma, diabetic peripheral neuropathy uye tinnitus nezvimwe zvirwere zvakakwezvawo kuwedzera kutarisisa. Saka chii chinonzi citicoline, chii chinonzi pharmacological effects, zviratidzo zvayo (chaiyo kurapa kwezvirwere zvipi), kushanda uye kuchengeteka?

Citicoline is one nucleotide inoumbwa ne ribose, cytosine, pyrophosphate uye choline. Ndiyo endogenous nucleotide yemuviri wemunhu. Inobatanidzwa munzira dzakawanda dzakakosha dzemetabolism mumuviri. Icho chigadziro chechisikigo che phospholipid synthesis ye neuron cell membrane chimiro uye precursor ye biosynthesis ye neurotransmitter acetylcholine.

Citicoline inonzi neuroprotective agent iyo inogona kuchengetedza tsinga dzetsinga, nekudaro kuderedza kana kudzivirira kufambira mberi kwechirwere. Parizvino, neuroprotective agents zvinowanzoshandiswa mukiriniki yekudzidzira zvinosanganisira calcium channel blockers, glutamate antagonists, free radical scavengers, uye cell membrane stabilizers, pakati peiyo citicoline ndeye cell membrane stabilizers.

Citicolineine-multi-target pharmacological effects, uye idzi nzira dzekuita dzinoita kuti ive nehukuru hunogona mukudzivirira neuroprotection uye kugadzirisa tsinga. Iine neuroprotection mhedzisiro yekuvharira kuitika kwekukuvara kweuronal uye tsinga yekugadzirisa mhedzisiro mushure mekuitika kwekukuvadzwa neuronal, iyo inowedzera iyo nguva yekurapa hwindo re citicoline.

Zvichienderana nemaitiro ayo emishonga, citicoline inoshandiswa zvakanyanya mukurapa sitiroko, kukanganiswa kwekuziva, kukuvadzwa kwehuropi, chirwere cheParkinson, glaucoma, chirwere cheshuga peripheral neuropathy, tinnitus nezvimwe zvirwere, uye kushanda kwayo uye kuchengetedzwa kwakasimbiswa mune dzakawanda zvidzidzo zvekiriniki, zvine humbowo hwakakwana-hwakavakirwa pakurapa. Stroke: sitiroko imhando yecerebral vascular blockage kana kuputika, zvichikonzera kukuvara kwehuropi kwekirasi yezvirwere, kusanganisira ischemic uye hemorrhagic sitiroko, iyo ischemic sitiroko ndiyo huru mhando yesitiroko, inoverengera 75% kusvika 90% yesitiroko ese. Njodzi yehupenyu hwesitiroko muhuwandu hwedu ndeye 35% -40.9%, chinzvimbo chekutanga munyika, kwete izvozvo chete, sitiroko ndiyowo chikonzero chekutanga chekufa nekuremara muvagari vedu.

Clinical research evidence:

1. Muna 2002, American Journal Stroke yakabudisa meta-analysis yemakiriniki ekuedzwa kune varwere vane acute ischemic sitiroko, iyo yakaratidza kuti oral citicoline yakawedzera mukana wevarwere vesitiroko kupora mushure memwedzi ye3 [1].

2. Muna 2009, tsvakurudzo yekuongorora zvinodhaka yakaitwa muSouth Korea kune varwere ve4191 vane acute ischemic sitiroko, uye zvigumisiro zvakaratidza kuti citicoline yakavandudza NIHSS mamakisi uye BI chikamu chevarwere vane zvikomborero mukutanga uye kunonoka kurapwa, uye kwenguva refu kushandiswa kwekushandisa kwaive kwakakura, uye maitiro ekurapa akanga akabatanidzwa zvakanaka nedosi. Kuvandudzwa kwacho kwainyanya kukosha muboka repamusoro-dose (≧2000mg / zuva), uye kushandiswa kwenguva refu kwakanga kwakachengeteka uye kwakabvumirwa [2].

3. Migumisiro ye-multicenter, randomized, double-blind, placebo-controlled controlled pilot study pamusoro pecerebral hemorrhage inoratidza kuti citicoline mishonga yakachengeteka yekurapa cerebral hemorrhage ine hutano hwakanaka hwekurapa [3].

4. Kuvhura-label, randomized, parallel study yakaongorora kuitika kwe citicoline pakukanganiswa kwekuziva kwepashure-stroke, uye zvigumisiro zvakaratidza kuti kushandiswa kwenguva refu kwe citicoline kwakagadzirisa zvakanyanya kukanganiswa kwekuziva kwepashure [4].