Kuchembera idanho rakaomarara, rakawanda, zvishoma nezvishoma rinoitika muhupenyu hwose. Nekufamba kwenguva, nhengo uye tsandanyama dzemuviri wemunhu zvichakura zvishoma nezvishoma, uye zvimwe zvirwere zvichaitikawo nekukura kwezera, kusanganisira cancer, chirwere cheshuga, chirwere chemoyo uye zvichingodaro.

Ongororo dzakawanda dzakaratidza kuti phytochemicals, kusanganisira polyphenols, flavonoids, terpenoids, nezvimwewo, inogona kurebesa hupenyu hune hutano kuburikidza ne-anti-oxidation, activation ye mitochondrial autophagy uye mamwe maitiro, uye ane anti-aging properties.

Pakutanga, vaongorori vakawana kuti sage inobvisa inogona kunonoka kuchembera mu vitro kuyedza, uye mune mbeva uye mumunhu in vitro modhi, sage inobvisa zvakanyanya kudzikisa huwandu hwakanaka-ane hukama nezera beta-galactose sidase masero, achiratidza anti-kuchembera zvivakwa.

Munguva ichangopfuura, Vatsvakurudzi vepaYunivhesiti yePadova muItaly vakabudisa pepa mumagazini Nature Aging rine musoro unoti "Targeting senescence inokonzerwa nezera kana chemotherapy ine polyphenol-rich.

Zvidzidzo zvakaratidza kuti kudya kwezuva nezuva kwesage kunotora kunogona kuwedzera hupenyu uye hupenyu hune hutano hwemakonzo, inhibisa zera-induced kuzvimba, fibrosis uye kuchembera mamaki mumhando dzakasiyana siyana, uye kuvandudza kuchembera phenotypes.

Muchidzidzo ichi, vatsvakurudzi vakaongorora simba rekurwisa kuchembera rekubvisa sage (HK) mu vivo kuburikidza nemhando yemakonzo, nekuwedzera madhasi akaderera eHK kumvura yekunwa yemazuva ese, uye akaongorora senescent cell kuunganidza mumakonzo, pamwe neakati wandei-ane zera paramita, kusanganisira hupenyu hurefu, hutano hwemuviri, fibrosis, bone mineralization, uye kuzvimba.

Vatsvakurudzi vakapa mbeva dzine mwedzi makumi maviri mvura yekunwa ine HK kusvikira dzafa.

Zvigumisiro zvakaratidza kuti mararamiro ehupenyu hwemakonzo muboka rekurapa kweHK aiva mwedzi 32.25, asi mararamiro ehupenyu hwemakonzo muboka rekutonga aingova mwedzi 28 chete. HK kurapwa kwakawedzera hupenyu nemwedzi 4.25, uye hupenyu hwemakonzo echikadzi nerume hwakawedzera zvakanyanya.

Histopathological analysis yeganda, chiropa, itsvo, uye mapapu emakonzo akawana kuti kurapwa kweHK hakuna kukonzera kuchinja kwehematopoietic parameters kana chepfu yenhengo, zvichiratidza kuti kurapwa kweHK kwakachengeteka.

Uye zvakare, kurapwa kweHK kwakavandudza kuchembera phenotypes mumakonzo zvichienzaniswa nekudzora, kusanganisira zvikamu zvehunchback, kukura kwebundu, uye chimiro chemvere dzemhuka.

Mhedzisiro iyi inoratidza kuti kurapwa kweHK kunogona kurebesa hupenyu hune hutano uye hupenyu hurefu hwemakonzo, uye hapana chepfu inoonekwa.

Kumwe kuongorora kwakawana kuti kurapwa kweHK kwakavandudza kuchembera phenotypes mumhando dzakasiyana dzematishu, kusanganisira kuvandudzwa kwebvudzi, pfupa, hutano hwetsandanyama, uye kushanda kweitsvo.

Ongororo yeMechanism yakaratidza kuti kurapwa kweHK zvakanyanya pasi-kwakadzora kuchembera gene set SAUL_SEN_MAYO, nepo up-regulated kuchembera gene set yakabatana nekuwedzeredza kwekuzvimba, immune activation, uye nzira dzine chekuita nezera, zvichiratidza kuti HK kurapwa kwakagadziridzwa transcriptome zvinhu zvine chekuita nekuzvimba nekuchembera. Uye zvakare, kuongororwa kwemhasuru, ganda, itsvo, uye mapapu zvakaona kuti kurapwa kweHK kwakaderedza mazinga ekuchembera mamaki mumhando dzakasiyana dzemuviri.

Pamusoro pekuchembera kwechisikigo, vaongorori vakawanawo kuti kurapwa kweHK kunogona kudzivirira kuchembera uye cardiotoxicity inokonzerwa nechemotherapy drug doxorubicin, ichiramba ichirapa.

Pakupedzisira, nokuti HK inotorwa ine zvakasiyana-siyana zvemiti yemiti, vatsvakurudzi vakaongorora zvinhu zvakananga izvo zvinoita basa rekudzivirira kukwegura, uye zvigumisiro zvakaratidza kuti flavonoid chikamu, luteolin (Lut), ndiyo inoshandiswa yeHK anti-kuchembera, iyo inovandudza kukwegura nekushandura kuwirirana pakati pe p16 neCDK6.

Kutorwa pamwe chete, chidzidzo chacho chakawana chidimbu chechisikigo chine anti-kuchembera mhedzisiro iyo yakavandudza sero uye kuchembera kwematishu, yakagadziridzwa zviratidzo zvine chekuita nezera senge fur, humpback, kuunganidzwa kwemakaki ekuchembera uye kukuvara kweDNA mumatishu, uye zvakanyanya kuwedzera hupenyu hwemhuka.