Youdaoplaceholder0 1.1 Iwo emuviri Mashiripiti e viscosity gradient: Katatu shanduko kubva mudumbu kuenda kukoloni .

Iyo molecular chimiro chepolyglucose inoumbwa neasina kurongeka-yakabatana glucose masara, uye iyi yakakosha conformation inoiisa yakasarudzika rheological properties. Mumudumbu mune acidic yakawanda (pH 1.5-3.5), cheni dzayo dzemamolecular dzinokurumidza kuumba matatu-dimensional network structure kuburikidza nehydrogen bond, uye viscosity inokurumidza kuwedzera kusvika 1200 mPa·s (inoda kuita kaviri iyo yeuchi), zvinobudirira kunonoka kupera kwedumbu nekusvika ku40% yekuzara uye kureba. Mushure mekupinda mudumbu mudiki, sezvo pH inokwira kusvika 6.0-7.5, mamwe mabhondi ehydrogen anotsemuka uye viscosity inodonha kusvika 300-500 mPa · s. Izvo hazvitadzise kunyura kwekudya kana kusanganisa ne bile acids kuderedza kunyura kwecholesterol. Kana ichisvika mucolon, pasi pekuita kwe microbial fermentation, viscosity inowedzera kuderera kusvika pasi pe50 mPa · s, ichibudisa pfupi-chain chain fatty acids (SCFAs) kupa simba kune probiotics (Mufananidzo 1).

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Youdaoplaceholder0 Tsigiro yedata:

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Gastric kuburitsa kunonoka mwero: 40% (Chikafu Hydrocolloids 2022, n=30)

Cholesterol absorption inhibition rate: 22% (GRAS certification data kubva kuUS FDA)

Kuwedzera kugadzirwa kweSCFAs: Colonic acetic acid concentration yakawedzera 3.8 nguva (Gut 2023, Animal Model)

Youdaoplaceholder0 1.2 "Precision feeding" zano reiyo microbiome

Iro viscosity regulation ye polydextrose haingogadziri maitiro ekudya kwemuviri, asiwo inoumba kushamwaridzana kwakasimba nemaruva emukati. Iyo yakakwirira viscosity state inoumba chipingamupinyi chemuviri muproximal colon, ichideredza kusangana pakati pepathogenic bacteria uye intestinal mucosa. Sezvo viscosity inoderera, zvishoma nezvishoma inoshandura kuita substrate inovirisa, inokurudzira kupararira kweBifidobacteria uye lactic acid mabhakitiriya. Chikwata kubva kuYunivhesiti yeCambridge chakawana kuburikidza nemetagenomic sequencing kuti kuenderera kunotora 12g / zuva repolydextrose kwemavhiki masere kunogona kukwidziridza F/B reshiyo yeThick-miliae/Bacteroidetes kusvika pa1.3 (ine hutano hwekutanga hwe1.5-2.0), uye kuwedzera kuwanda kweFaisy ne58% yebhakitiriya rebutcaliuch. Iyi mbiri-nhanho mhedzisiro ye "kudzivirira kutanga, ipapo chikafu" inonyatso kuzadzisa zvidikanwi zvezvakatipoteredza zvezvikamu zvakasiyana zvedumbu remukati.

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Youdaoplaceholder0 Chitsauko 2 Yechishandiso Scenario Revolution: Kuyambuka-muganho Kupinda kubva kune Shuga-inodzorwa Chikafu kuenda kuICU Nutrition

Youdaoplaceholder0 2.1 Indasitiri yeChikafu: Iyo "isingaoneki skeleton" yeLow GI zvigadzirwa

Mumunda wekubika, iyo yakakwira-inobata mvura (> 8g mvura / g) uye kugadzikana kwekupisa (kushivirira kusvika 200 ℃) yepolyglucose inoita kuti ive yakanaka inotsiva sucrose. Iyo "Zero Sugar Cookies" yakatangwa neMeiji Group yekuJapan inoshandisa polyglucose seyakakosha fiber, ichiwana chete 1.2g yemacarbohydrates ega pacookie, uye magadzirirwo uye crispness hazvina kusiyana neizvo zvezvigadzirwa zvine shuga. Zvinotonyanya kukosha, iyo viscosity regulation mudumbu diki inogona kunonoka kutora glucose uye kuderedza postprandial yeropa glucose peak ne34% (Clinical data kubva kuDiabetes Care 2021).

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Youdaoplaceholder0 Innovative kesi:

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Youdaoplaceholder0 Nestle : Iyo "Smart inononoka-kuburitsa simba bar" yakagadziriswa nekubatanidza polydextrose ine resistant dextrin inoratidzira viscosity gradient dhizaini inowedzera kunyura kabhohaidhiretsi kusvika kumaawa matanhatu, ichisangana nekuenderera kwesimba rekupa zvinodiwa nevamhanyi vemarathon.

Youdaoplaceholder0 Nongfu Chitubu : Yakatangwa "Intestinal Vitality Sparkling Water" ine polyglucose yakawedzerwa, inoshandisa yakaderera-viscosity fermentation midziyo kugadzira gasi rakapfava mukoloni kukurudzira intestinal peristalsis. Yakatengesa mabhodhoro emamiriyoni zana mumwedzi mitatu.

Youdaoplaceholder0 2.2 Zvokudya zvinovaka muviri: Iyo "intestinal barrier Guard" yevarwere veICU.

Intestinal mucosal barrier failure muvarwere vanorwara zvakanyanya kazhinji inotungamirira kuhutachiona hwehutachiona. Muedzo wakasarudzika (n = 158) wakaitwa neFirst Affiliated Hospital yeZhejiang University wakaratidza kuti varwere veICU vakawedzerwa ne15g yepolyglucose zuva nezuva vaive ne42% kuderera kwechiitiko cheendotoxemia uye kuderedzwa kwe29% muintestinal permeability index (plasma ligonin). Iyo nzira iri pakuti iyo yakakwirira-viscosity state inoumba firimu rinodzivirira mudumbu, kuderedza dambudziko rekushungurudzika-induced ulcers. Iyo butyric acid inoburitswa nechikamu checolonic inosimudzira kukora kwemucus layer (inowedzera huwandu hwemasero egoblet ne37%), kuwana kusimbiswa kwemuviri uye kemikari mbiri mbiri.

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Youdaoplaceholder0 Chitsauko 3 Technological Breakthrough: The Upgrade kubva 'Empirical Formulas' kuenda ku' Computational Nutrition '

Youdaoplaceholder0 3.1 Kunyatso kudzora kwema molecular modification

Iyo viscosity yekupindura huwandu hwechinyakare polydextrose ishoma, zvichiita kuti zviome kunyatso kuenzanisa zvinodiwa nemunhu. Muna Chikumi 2023, DSM yekuNetherlands yakazivisa tekinoroji yayo ine patent "PolySmart?", iyo yakagadzira matatu eviscosity curve akasiyana nekudzora dhigirii repolymerization (DP kukosha) kweglucose uye sorbitol:

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Youdaoplaceholder0 G type ? (kuwedzera kwemudumbu) : Viscosity inosvika 1500 mPa·s pa pH

Youdaoplaceholder0 C type ? (colon-targeted) : Viscosity inodonha zvakanyanya kusvika pa30 mPa·s papH > 6.5, inosarirwa kune vanhu vane constipation;

Youdaoplaceholder0 Rudzi B (yakaenzana modhi): Shanduko yakapfava yehutumbu huzere viscosity, inokodzera kutonga kweglucose yeropa muvarwere vane chirwere cheshuga.

Youdaoplaceholder0 3.2 AI-Inobatsirwa Kugadzira dhizaini

Iyo "FiberEngine" papuratifomu yakagadziridzwa nekambani yeIsrael NutriAI inobatanidza 2 miriyoni gut microbiota data uye fluid dynamics modhi, iyo inogona kufanotaura iyo yakakwana yekuwedzera huwandu hwepolydextrose pasi pemakore akasiyana uye mamiriro echirwere. Semuenzaniso, kune varwere vane IBS (Irritable Bowel syndrome), iyo system inokurudzira kusanganiswa kwezuva nezuva kwe8-10g yepolyglucose uye 2g yefructooligosaccharides, iyo inoderedza kuitika kwechirwere chedumbu ne 65% (2023 user tracking data).

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Youdaoplaceholder0 Chitsauko 4 Indasitiri Kuvhiringidzika: Iyo "Fiber Blue Ocean" iyo Giants iri kurwira.

Youdaoplaceholder0 4.1 Mujaho wekugona unopisa

Saizi yemusika wepasi rose wepolydextrose inotarisirwa kukura kubva pa870 miriyoni emadhora ekuAmerica muna 2023 kusvika pamabhiriyoni 2.1 emadhora muna 2030 (CAGR 12.3%). China yave nhandare huru yehondo.

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Youdaoplaceholder0 Baolingbao Bio : Isai 500 miriyoni yuan kuwedzera zviuru makumi matatu zvematani pagore mutsetse wekugadzira, uchishandisa enzymatic synthesis process kuti uwane 99.5% kuchena;

Youdaoplaceholder0 Rogate : Probiotic-polyglucose microcapsules yakagadzirwa nekubatana neCHR. Hansen yakawedzera chiyero chekupona kweasidhi kusvika ku90%;

Youdaoplaceholder0 Matsuya Chemie, Japan : Yakaunzwa "nano-fibrotic polyglucose," iyo ine kunzwisiswa kweviscosity regulation zvakapetwa katatu uye yakapihwa zita remishonga yenherera neFDA yechirwere chebowel syndrome.

Youdaoplaceholder0 4.2 Zvinetso zviviri zvekutonga uye kuziva

Kunyange zvazvo polydextrose yakagamuchirwa sezvokudya zvekudya neEuropean Union, China nedzimwe nyika, vatengi vachiri kusanzwisisa. Ongororo yakaitwa neFMCG muUnited States inoratidza kuti 28% chete yevatengi vanogona kunyatsosiyanisa mutsauko unoshanda pakati pepolydextrose neresitorendi starch. Zvakanyanya kuoma, kunwa zvakanyanya (> 50g / zuva) kunogona kukonzera dumbu redumbu kana kukanganisa kunyura kwemaminerari. Iyo indasitiri inoda nekuchimbidza kumisa yakamisikidzwa dosage nhungamiro.

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Youdaoplaceholder0 Chitsauko 5 Kutarisa kumberi: Iyo "fiber Network" kubva kuGUT kuenda kuBody Health

Youdaoplaceholder0 5.1 Humbowo hutsva hwekutonga kwebrain-gut axis

Mukutanga kwa2024, California Institute of Technology yakawana mukuyedza mbeva kuti butyric acid inogadzirwa nekuviriswa kwepolydextrose inogona kumutsa hypothalamic neurons kuburikidza ne vagus nerve, ichidzikisa hunhu hwekushushikana ne43%. Izvi zvinopa tsananguro yemolecular-level yekutaura kuti "kudya kwepamusoro-fiber kunovandudza hutano hwepfungwa".

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Youdaoplaceholder0 5.2 Zvinokanganisa Zvitsva muSynthetic biology

Iyo US yekutanga Zymergen yakashandisa CRISPR tekinoroji kugadzirisa Trichia pastoris, ichiita kuti ikwanise kuburitsa zvakananga "gene-edited polyglucose" ine yakagadziridzwa viscosity curve. Ichi chigadzirwa chakaratidza 80% kuvandudzwa kwepH mhinduro yechokwadi muyedzero yekuyedza digestion uye inotarisirwa kupinda mukiriniki yekuyedza nhanho muna 2025.

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Youdaoplaceholder0 Mhedziso: Kutsanangura patsva "yakangwara miganhu" yeFiber

Iyo viscosity gradient mhedzisiro yepolydextrose inoratidza nguva nyowani yekudya fiber, ichibva pa "passive supplementation" kuenda ku "active regulation". Kana chikamu chefaibha chichikwanisa kuzvimiririra kuita basa rayo mukupindura nharaunda yekugaya, tinogona kunge tiri kuona shanduko yeparadigm musaenzi yehutano - kupindira mune remangwana rehutano hakuchave kuri kwega kuedza kwemorekuru, asi dhanzi rekubatana rezvinhu zvakangwara, microbiome, uye hungwaru hwekugadzira. Semunhu akahwina Mubairo weNobel muChemistry, Frances Arnold, akamboti, "Mamorekuru ari muchisikigo anotova nezvinobvira zvisingaperi. Chatinofanira kuita kudzidza kuteerera 'mutauro wavo wenguva nenzvimbo'."