1. Zvakanakira zvemagetsi maitiro uye kutonga kweglucose yeropa

1. Zero macalorie uye hapana metabolic residu
Mushure mekunge mamolecular chimiro che sucralose chagadziriswa neklorini, hurongwa hwekugaya kwevanhu hwakatadza kuibvisa kuita shuga inonwika. Data yekiriniki inoratidza kuti inenge 85% inobudiswa zvakananga kuburikidza nemudumbu mushure mekudya, uye iyo yakasara 15% inogadziriswa nechiropa mumishonga isiri-chepfu uye inobudiswa muweti 13. Ichi chivakwa chinoita kuti ive yechokwadi "zero calorie" inotapira, isina yakawedzera mutoro wesimba kune vane chirwere cheshuga padosi yezuva nezuva inosvika 9mg/kg uremu hwemuviri 28.

2. Ropa glucose kugadzikana nzira
No insulin stimulation : Chidzidzo che 2024 chakaitwa neInternational Diabetes Federation (IDF) chakaratidza kuti sucralose haina kuita kuti inotapira kuravira receptor T1R2/T1R3 mupancreatic beta masero uye haina kukonzera insulin secretion 57.
Dzivisa kunyura kweglucose ?: Kusiyana nesucrose, sucralose haikanganise basa reSGLT1 glucose transporter mudumbu diki, uye mudumbu glucose absorption inochengetedzwa pamwero wakajairika 36. Semuyenzaniso, vanhu makumi mashanu vane Type 2 chirwere cheshuga vakadya zvinwiwa zvine sucralose kwemazuva makumi matatu akateedzana vaive nekuchinja kusingasviki 0.3% mumazinga avo eA1c (HbA1c) 5.
Chechipiri, kukosha kunoshanda kwekutonga kwekudya

1. Kugona kutsiva zvechivanhu shuga
Iko kutapira kwe sucralose kwakapetwa ka600 kweiyo sucrose, uye ishoma chete inogona kugutsa kuravira zvinodiwa. Semuyenzaniso:

Kuwedzera 30mg sucralose kune 300ml chinwiwa chisina shuga chinogona kuwana kutapira kwakaenzana ne10% sucrose solution 16;
Kuwedzera 15mg pa100g yega yega yeupfu muzvinhu zvakabikwa kunoderedza kudyiwa kwe sucrose neanenge 45g 48.

2. Dietary structure optimization effect
Deredzai kutsamira pamakabhohaidhiretsi : Nekutsiva macarbohydrates echinyakare, vane chirwere cheshuga vanogona kuderedza kudya kwemazuva ose kwemacarbohydrates ne50-80g, zvakaenzana nekucheka 200-320kcal macalorie 27;
Kuvandudzwa kwekudya kwakasiyana-siyana : Kuwedzera kugamuchirwa kwekudya kwechirwere cheshuga neinopfuura 40% nekubvumira kunwiwa kwakachengeteka kwezvokudya zvinotapira zvakanyanya seaizikirimu nekeke 38.
Chechitatu, kudzivirira kukanganisa kwehutano hwehutano

1. Dzivirira matambudziko echirwere cheshuga
Inoderedza njodzi yemeno caries : Mabhakitiriya emumuromo haagone kuputsa sucralose, uye maitiro ayo anorwisa-caries anoderedza huwandu hwehutachiona hwemukanwa ne27% muvanhu vane chirwere cheshuga 46;
Kuchengetedza hurongwa hwemwoyo : Mushure mekutsiva sucrose, mazinga evarwere etriglyceride akadzikira neavhareji ye0.4mmol/L uye low-density lipoprotein (LDL) yakadzikira ne12% 78.

2. Kuchinjika kune akakosha mascenario
kugadzikana kwekushisa kwakanyanya : kana uchibika pasi pe120 ℃, sucralose haiburitse zvinhu zvine chepfu senge chloropropanol, iyo yakakodzera kugadzira shuga yakaderera-38;
Kupindirana kwemishonga : haina kudyidzana neanowanzo shandiswa zvinodhaka zve hypoglycemic senge metformin uye insulin, asi zvinofanirwa kutorwa nemishonga inorwisa macoagulant yakadai sewarfarin 27 paawa ye2.
Chechina, zvepfungwa uye zvemagariro zvinobatsira

1. Kuvandudzwa kwehupenyu
Varwere vane chirwere cheshuga vane 62% kuderedzwa kwekunetseka kwepfungwa nekuda kwekushaiwa kutapira uye avhareji 3.2 point kuderedzwa muDepression Scale (PHQ-9) chikamu 68. Ongororo ye2024 yeVatengi yakaratidza kuti kugutsikana kwechikafu pakati pevaneshuga vakashandisa sucralose sechinzvimbo cheshuga kwakawedzera kubva pa43% kuenda pa79%3.

2. Economic cost optimization
Kuderedza mari yekurapa: inogona kuderedza mutengo wepagore wekurapwa kwechirwere cheshuga, retinopathy uye mamwe matambudziko anosvika 3200 yuan/munhu 78;
indasitiri yechikafu innovation : Kurudzira musika wekudya usina shuga kuti ukure ne18% pagore uye unotarisirwa kusvika 120 bhiriyoni yuan 14 muna 2025.

5. Tsanangudzo yekushandiswa uye tarisiro yeramangwana

1. Nheyo dzekushandiswa kwesainzi
Dose control : Tevedzera iyo WHO yakakurudzirwa yepamusoro muganho we9mg/kg uremu hwezuva nezuva hwemuviri (inenge 540mg ye60kg vakuru) ?28;
Kusarudzwa kwemaitiro : Zvigadzirwa zve tekinoroji zve microencapsulation zvaisarudzirwa kuderedza kukanganiswa kwemaruva emudumbu (kuderera kwekuita kwebifidobacterium kwakaderedzwa kubva pa30% kusvika pa8%) 18.

2. Tekinoroji yekuvandudza nzira
Kunyatso kudzora tekinoroji : Iyo "directed chlorination" maitiro akagadzirwa neJinhe Indasitiri muna 2025 inoderedza huwandu hwasara hwechloropropanol kusvika 0.01ppm 8;
Tsvagiridzo yezvekurapa yakavakirwa nehumbowo : International Diabetes Association inotangisa 100,000-munhu cohort kudzidza kuongorora kwenguva refu mhedzisiro ye sucralose pane islet function 56.
mhedziso
Sucralose inopa varwere vane chirwere cheshuga mhinduro inoenzanisa kuravira zvinodiwa nehutano hwehutano. Hunhu hwayo hwakakosha hwakaiswa mune metabolic inertia, kugadzikana kweglucose yeropa uye kudzivirira kunetsa. Nemaitiro akavandudzwa ekugadzira (senge microencapsulation tekinoroji) uye akagadziridzwa masisitimu ekutonga (sekudzokororwa kweChina Nutrition Labeling Guidelines yePre-Packaged Foods muna 2025), sucralose ichava chishandiso chakachengeteka uye chinoshanda chekudya kwechirwere cheshuga. Nekudaro, zvinofanirwa kusimbiswa kuti chinotsiva shuga hachigone kutsiva chinzvimbo chepakati chekudya kwakaringana uye kurapa kwekurovedza muviri, uye kushandiswa kwesainzi kunofanirwa kunge kwakavakirwa pagwaro rekurapa rega rega.