Ca HMB, zita rakazara β-hydroxy-β-methylbutyrate calcium, ndeimwe yeakajairika maitiro ekuwedzera eHMB (β-hydroxy-β-methylbutyrate). Beta-hydroxy-beta-methylbutyric acid (HMB) inowanikwa zvakanyanya mumichero yecitrus uye mimwe miriwo senge broccoli, nyemba dzakadai sealfa, uye dzimwe hove nehove. β-hydroxy-β-methylbutyrate calcium (Ca HMB) inonzi calcium salt ye β-hydroxy-β-methylbutyrate (HMB). Nekuda kwekushanda kweHMB, kuitira kufambisa kuchengetedza nekushandisa, kazhinji inoshandurwa kuita calcium munyu kana ichigadzirwa, uye chikamu chikuru cheHMB chemukati chinobva pa77-82%.

HMB ndeyepakati metabolite yemunhu yakakosha amino acid leucine, uye muviri wemunhu unogona kuburitsa shoma shoma yeHMB pachayo. Muzvokudya zvakajairika, muviri wemunhu unobereka anenge 300 kusvika 400 mg pazuva, iyo 90% inobva ku catabolism ye leucine. HMB inogona kushandiswa kukurudzira kukura kwemhasuru, kuwedzera kusadzivirirwa, kuderedza cholesterol uye yakaderera density lipoprotein mazinga mumuviri kuderedza kuitika kwechirwere chemoyo uye chirwere chemoyo, asiwo kuwedzera kugona kwemuviri kugadzirisa nitrogen, kuchengetedza mazinga eprotein mumuviri, uye kudzivirira kuparara kwemisumbu muvarwere vakarara kana vakaoma mitezo. Mumakore achangopfuura, nekuti inogona kuderedza kukuvadzwa kwetsandanyama mushure mekuita maekisesaizi, kugadzirisa tsandanyama fiber, kuwedzera mhasuru simba uye kupisa mafuta emuviri, yave chinhu chenyeredzi muzvigadzirwa zvemitambo zvinovaka muviri. Pamusoro pezvo, HMB yakaratidzirwa nekiriniki kuti ikurumidze kupora maronda uye kumisa kuzvimba. Zvidzidzo zvakaratidza kuti Ca HMB inogona kukurumidzira mapuroteni synthesis uye kunonoka kudyiwa kweprotein. Ca HMB yakasanganiswa ne glutamine uye arginine inogona kuvandudza yakashata nitrogen chiyero chevarwere uye kuita basa rakanaka mukupora kubva mukushungurudzika nekuvhiyiwa.

Muna 2011, yaimbova Ministry of Health yeChina yakazivisa kubvumidzwa kwe β-hydroxy-β-methylbutyrate calcium.Ca HMB) sechikafu chitsva chekushandisa, kushandiswa kwechikafu chekudya kwemitambo, chikafu chakakosha chekurapa chikafu, iyo yakakurudzirwa ≤3 magiramu / zuva. Muna 2017, National Health and Family Planning Commission yakazivisa kuwedzera kwechikamu chekushandisa cheCa HMB kubva pamanyorerwo maviri ekutanga kusvika papfumbamwe, uye yakaraira masangano ekuongorora njodzi kuti aite ongororo dzekuchengetedza. Kushandiswa kweCa HMB kwakawedzerwa kuti kusanganise zvinwiwa, mukaka uye zvigadzirwa zvemukaka, cocoa zvigadzirwa, chokoreti nechokoreti zvigadzirwa, zvihwitsi, zvakabikwa, uye chikafu chakakosha chekudya, uye huwandu hwakakurudzirwa hwaive huchiri ≤3 g / zuva, iyo isingapfuure chiyero chevanhu vanozvipira. Ca HMB yakazivikanwa seGRAS neUS Chikafu neDrug Administration muna 1995 uye inoshandiswa mukurapa chikafu chekudya uye chikafu chakakosha. Mumakore makumi maviri apfuura, Ca HMB yakashandiswa zvakanyanya muzvigadzirwa zvemukaka, zvigadzirwa zvechokoreti, zvinwiwa, mabhawa emagetsi uye zvimwe zvekudya mumusika weUS. Ca HMB chikafu chekudya chinobvumirwa nemirairo yeJapan, iyo inogona kuwedzerwa munzvimbo dzakawanda dzakadai sechikafu chekudya, chikafu chemitambo chekudya, kuderedza uremu, chikafu chekunaka, nezvimwewo. Inogonawo kushandiswa sechinhu chinoshanda muzvokudya zvinowedzera zvakadai se capsules, mapiritsi, zvinwiwa zvakasimba. Kune vagadziri uye ma pharmacy, Ca HMB parizvino ndeimwe yeanonyanya kufarirwa hutano zvigadzirwa pamusika weJapan.

HMB inoshandiswa zvakanyanya muzvinwiwa zvakasimba, uye zvigadzirwa zvakadaro zvakare zvakawanda mumusika wepasirese. Semuyenzaniso, Juven yakatangwa naAbbott kusimudzira mapuroteni synthesis, Myoplex Muscle Armor yakatangwa neEAS muUnited States, Fracora yezera repakati nepakati uye chembere mhasuru hutano hwakagadzirwa neConcord muJapan, nezvimwewo, zvese zvinoenderana neHMB seyakanyanya mbishi zvinhu. Kune HMB zvinwiwa zvemvura, chikumbiro chemumba chiri padanho rekutanga, asi makambani ekunze akazvishandisa uye ari mushishi rekuvandudza zvishoma nezvishoma. Semuenzaniso, chinwiwa chemitambo SUISPO chakatangwa nekambani yeJapan ISDG, uye runako rwemuromo wemvura Flowage yakatangwa neJapan Concord. Sechikafu chitsva chekudya chinogona kuwedzerwa kune zvinwiwa, HMB inogona kusanganiswa nemapuroteni akasiyana-siyana, senge whey protein concentrate, mukaka protein concentrate, whey protein isolate, uye yemiriwo protein, uye inogona zvakare kushandiswa nevhitamini nemamineral magadzirirwo ekuwedzera chigadzirwa. Mvura yemukaka nehupfu hwemukaka neHMB inogona kushandiswa kune vezera repakati uye vanhu vakwegura kubatsira kudzivirira kuora kwemhasuru, uye inogonawo kushandiswa kune vemitambo uye kugwinya vanhu kupa mhasuru hutano hutano hwekuwedzera. Pamusoro pezvo, imwe yogati inoshanda pamusika, kuwedzera HMB inogona kukwidziridza iyo yekutanga chigadzirwa pfungwa uye kupa pfungwa yekudzikisa mafuta uye kuumbwa kwechimiro, uye kuwedzera inoshanda mbishi zvinhu kune ice cream zvakare inzira yekuvandudza yevakawanda vagadziri ve ice cream. Kuwedzera zvinongedzo zveHMB zvinogona kusimbisa kushanda kweaizi cream pachigadziro chekuona kunaka uye kuravira. Pamusoro pezvo, HMB inogona zvakare kushandiswa mumabhawa ezvekudya uye zvihwitsi, senge yakakurumbira chikafu chekudya bar chigadzirwa chinonzi Maximuscle, iyo inowedzera 20 magiramu eprotein, 3.4 magiramu e creatine monohydrate uye 1.6 magiramu eHMB, iyo inoshambadzirwa kuderedza kuparara kweprotein, kuvaka tsandanyama uku ichikurudzira kupora mushure mekurovedza muviri. Vagadziri vezvekudya zvekurasikirwa nemafuta vagara vachishandisa HMB kune zvihwitsi, senge kambani yeJapan ISDG inogadzirwaHMBcandy, inova siwiti yevanhu vanovaka tsandanyama uye vanorasikirwa nemafuta.

Sekupindira kunobatsira kwekudya kwekudzivirira uye kurapwa kwemuscular decay syndrome,HMByakasimbiswa nehuwandu hwezvidzidzo zvekiriniki, uye HMB yakave yakaratidzwa nekiriniki kuti ikurumidze kuporesa maronda uye kudzivisa kuzvimba. Parizvino, kusimudzira uye kushandiswa kweHMB mumunda wekudya kwemumba kuchangotanga, asi nekubviswa kwezvipingamupinyi zvemumba, pamwe nekusimuka nekusimudzirwa kwezvakasiyana HMB zvinoshanda zvekudya mumusika wepasi rose, zvinotendwa kuti munguva pfupi iri kutevera, HMB ichava netarisiro yakakura yebudiriro mumunda wekushandiswa kwechikafu.