Vitamin B3, inozivikanwawo se niacin, ivhitamini inonyungudika mumvura inoita zvakasiyana siyana zvakakosha zvemuviri mabasa mumuviri. Zvidzidzo zvepakutanga zvakaratidza kuti vhitamini B3 inotora chikamu musimba remuviri metabolism, inosimudzira metabolism yemasero eganda, uye zvakare ine imwe antioxidant mhedzisiro.

Non-alcoholic fatty chiropa chirwere (NAFLD), ndicho chiitiko chepamusoro chechirwere chisingaperi chechiropa rudzi muChina, kune vanopfuura mamiriyoni e150 varwere muChina, iyo 10-20% ichawedzera kukura kuva isiri doro steatohepatitis (NASH), inonyanya kuratidzwa nekuputika uye kukuvara kwechiropa, kazhinji kunoperekedzwa nefibrosis. NASH inofambira mberi nekukurumidza uye ine njodzi huru yekubatwa nezvirwere zvakakomba zvechiropa senge cirrhosis negomarara rechiropa.

Munguva pfupi yapfuura, Vatsvakurudzi veChikoro cheHutano Hwevanhu paSun Yat-sen University vakabudisa pepa mumagazini yeJAMA Network Open ine musoro unoti "Dietary Niacin Intake and Mortality among Individuals With Nonalcoholic. Fatty Liver Disease" tsvakurudzo yepepa.

Chidzidzo chacho chakaratidza kuti kuwedzera kwevhitamini B3, kana kuderedzwa kwengozi yezvose-zvinokonzera rufu kune varwere vane chirwere chisingaiti chechiropa chechiropa, chakabatanidzwa nekuderedza 30% mungozi yekufa-kunokonzera rufu kune vatori vechikamu vane kudya kwakanyanya (≥26.7mg / zuva) zvichienzaniswa nevatori vechikamu vane zuva rakaderera 18 ≤.

Muchidzidzo ichi, vatsvakurudzi vakaongorora kushamwaridzana pakati pekudya kwevhitamini B3 kudya uye ngozi yezvose-zvinokonzera rufu kune varwere vane chirwere chisingaiti chiropa chechiropa nekuunganidza kudya kwevhitamini B3 kutora kubva kuNational Health and Nutrition Examination Survey (NHANES) dhatabhesi ye4,315 NAFLD varwere vane avhareji yemakore 53.

Vatori vechikamu vakakamurwa kuva mapoka matatu zvichienderana nevhitamini B3 kudya: kuderera kweboka (≤18.4mg / zuva), boka repakati rekudya (18.5-26.6mg / zuva) uye boka repamusoro rekudya (≥26.7mg / zuva).
Munguva yenguva yekutevera yekutevera yemakore 8.8, huwandu hwekufa kwe566 hwakanyorwa, 197 yavo yainzi yakakonzerwa nechirwere chemoyo.

Ongororo iyi yakawana kuti vatori vechikamu vane yakanyanya kudyiwa vaive ne30 muzana yakaderera njodzi yezvese-zvikonzero rufu zvichienzaniswa nevatori vechikamu vane yakaderera kudya.

Pamusoro pezvo, vatori vechikamu vane huwandu hwepamusoro vaive nekuderedzwa kwe35 muzana mungozi yekufa kwemoyo, asi izvi zvaive zvisina kukosha.

Kumwe kuongorora kwakawana kusangana kwakakosha pakati pekudya kwevhitamini B3 uye njodzi yechirwere cheshuga uye zvese-zvinokonzera rufu, nekuderera kukuru kwekufa kwevarwere vasina chirwere cheshuga kana vachienzaniswa nevaya vane chirwere cheshuga.

Maererano nevatsvakurudzi, niacin ndeimwe yevanotangira NAD synthesis uye yava chinangwa chakakosha chekudzivirira uye kurapwa kwechirwere chechiropa. Zvidzidzo zvekupindira kwevanhu zvakaratidzawo kuti niacin inogona kuvandudza chiropa chechiropa uye kuderedza mafuta echiropa. Muzvidzidzo zvepreclinical, niacin yakawanikwa ichidzivirira uye kudzorera chiropa steatosis uye kuzvimba, uye kudzivirira fibrosis. Iyi mhedzisiro inowanikwa nekudzikisa oxidative kusagadzikana, inhibiting diacylglyceryl acyltransferase 2 uye NADPH oxidase basa, uye dzimwe nzira dzinogona kuitika.

Zvakakodzera kutaura kuti munaGunyana 2023, Vatsvagiri kubva kuChikoro cheHutano Hwevanhu paSun Yat-sen University vakaburitsa bepa mupepanhau Nutrients rakanzi "Kubatana pakati peDietary Niacin Intake uye Nonalcoholic Fatty Liver Disease: NHANES 2003-2018 "bepa reongororo.

Chidzidzo chacho chakaratidza kuti vhitamini B3 yekuwedzera yaibatanidza nengozi yakaderera yeasina kudhakwa mafuta ane chiropa chirwere, nevaya vane yakanyanya niacin kudya (≥29.2mg/ zuva) vane 31% yakaderera yengozi ye-nonalcoholic fatty chiropa chirwere kana ichienzaniswa nevaya vane yakaderera niacin kudya (≤16.3mg/ zuva).

Kutorwa pamwe chete, mhedzisiro inoratidza kuti vhitamini B3 yekuwedzera inosanganiswa nenjodzi yakaderera yeasina kudhakwa mafuta echiropa chirwere uye kuderedzwa kwengozi yezvose-zvinokonzera rufu kune varwere vane nonalcoholic fatty chiropa chirwere. Imwezve tsvakurudzo inodiwa kusimbisa iyo yakakwana dose yevhitamini B3 kuderedza njodzi yezvose-zvinokonzera rufu kune varwere vane NAFLD.