Chirwere chedoro chechiropa (ALD), chinova chirwere chechiropa chinokonzerwa nekudhakwa kwenguva refu, chimwe chezvirwere zvechiropa zvakajairika muChina, zvinosanganisira doro rine mafuta echiropa, doro hepatitis, doro rinodhaka fibrosis uye doro cirrhosis. Mumakore achangopfuura, kuwanda kwechirwere chechiropa chedoro kwakaratidza kuwedzera kwemaitiro muChina.

Musi waChikunguru 2, 2024, Liu Zhihua weTsinghua University, Wang Hua weAnhui Medical University, Yin Shi weYunivhesiti yeSainzi neTekinoroji yekuChina nevamwe vaongorori vakaburitsa chinyorwa chine musoro unoti "Dietary fiber inoderedza kukuvadzwa kwechiropa nedoro kuburikidza" mujenari Cell Host & Microbe "Bacteroides acidifaciens and subspeciation ammonia".

Kudya kwakapfuma mu soluble dietary fiber kwakawanikwa kuwedzera kuwanda kweB accidifaciens uye kuderedza doro-induced chiropa kukuvara mumakonzo.

Pamashini, B.accifaciens inogadzirisa bile acid metabolism kuburikidza nebile saline hydrolysis enzyme (BSH). Kuwedzera kweunbinding bile acid kunoshandisa FXR-FGF15 nzira mumatumbo, inodzivirira intestinal barrier function, inokurudzira kutaura kwe ornithine aminotransferase (OAT) mu hepatocytes, uye nokudaro inokurudzira metabolism ye ornithine yakaunganidzwa muchiropa kuti iite glutamate. Ipa zvigadzirwa zvechiropa detoxification uye kuderedza kukuvara kwesero rechiropa.

chidzidzo ichi, vatsvakurudzi vakatanga kukonzera doro chirwere chechiropa mumuenzaniso wembeva uye vakaongorora migumisiro yezvokudya zvefiber pachirwere chechiropa chinodhaka mumakonzo nekuwedzera zvose zvinonyunguduka uye zvisingasviki fiber.

Mhedzisiro yacho yakawana kuti soluble dietary fiber supplementation yakanyanya kuvandudza doro rechiropa chirwere mumakonzo, kusanganisira kuderedza chiropa steatosis uye kuderedza chikamu uye huwandu hwese hwechiropa neutrophils, nepo insoluble dietary fiber haina kuita yakakosha.

Nekuti fiber yekudya inogona kukanganisa zvakanyanya gut microbiota, vaongorori vakaongororazve kana kuvandudzwa kwechirwere chechiropa chedoro kwakakonzerwa negut microbiota kuburikidza ne microbiota transplantation maitiro.

Mushure mekuisirwa, zvakaonekwa kuti kufambisa iyo microflora yemakonzo akadyiswa soluble dietary fiber yakaderedza serum alanine aminotransferase (ALT) uye aspartate aminotransferase (AST) mazinga, nekuderedza chiropa steatosis uye mazinga ekuzvimba, zvichiratidza kuti soluble dietary fiber inogona kukanganisa kukura kweALD nekugadzirisa zvakare kuumbwa kwemukati microflora.

Chidzidzo chacho chakaratidza kuti soluble dietary fiber yakavandudza chiropa cell necrosis, chiropa steatosis uye kuzvimba mumuenzaniso wembeva yedoro chirwere chechiropa, uye zvakare yakaderedza ropa reammonia uye oxidative kusagadzikana, zvichiratidza basa rinokosha re soluble dietary fiber mukudzivirira uye kurapwa kwechiropa chechiropa chirwere.

Zvakakosha kuziva kuti vanhu vakuru vanowanzokurudzirwa kushandisa 25-30 gramu kana kupfuura yefiber fiber pazuva, asi vanhu vazhinji havasangane nezvinokurudzirwa zvekudya. Mbeu dzakakwana, michero nemiriwo zvakapfuma zvefiber yekudya uye zvinogona kupa mamwe mamicronutrients akakosha.

Muchidimbu, zvigumisiro zvinoratidza kuti kudya kwakapfuma mu-soluble dietary fiber kunogona kuvandudza doro-induced chiropa kukuvara mumhando yemakonzo apo ichidzivirira kutendeseka kwemukati wemukati. Chidzidzo ichi chine humwe kukosha kwekiriniki uye kukosha kwemagariro.

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