Zvidzidzo zvepakutanga zvakaratidza kuti vhitamini C ine hutano hwakasiyana-siyana, kusanganisira immune system, antioxidant mhedzisiro, uye hutano hwemoyo. Kunyange zvazvo vhitamini C iri chikafu chakakosha chekuchengetedza hutano, yakawandisa kana zvishoma inogona kuva nemigumisiro yakaipa pahutano.

Melanoma (MM) ibundu rakashata rinotangira mumasero ane pigmented eganda uye imhando ine njodzi zvakanyanya yegomarara reganda, kunyangwe ine chiitiko chakaderera uye ine hukasha uye metastatic. Kuwanda kwe melanoma kwave kuchiwedzera mumakumi mashoma emakore apfuura.

Munguva pfupi yapfuura, Vatsvagiri kubva kuYunivhesiti yeSouth Florida kuUnited States neYunivhesiti yeLeicester kuUnited Kingdom vakaburitsa bepa rine musoro unoti "Redox modulation of oxidatively-induced DNA kukuvadzwa neascorbate inowedzera" mupepanhau Free Radical Biology uye Medicine zvose mu vitro uye ex-vivo DNA kukuvara kuumbwa uye kufa kwesero mumaseru e melanoma ".

Zvidzidzo zvakaratidza kuti kurapa melanoma cancer maseru nevhitamini C kunogona kuwedzera oxidant-induced DNA kukuvadzwa kumasero egomarara uye kukurudzira cancer cell kufa, uye kukuvara uku kunoenderana nehuwandu hwe melanin mumaseru. Uye kumasero eganda akajairika, anoita basa rekudzivirira.

Muchidzidzo ichi, vaongorori vakagadzira boka reMM cell mitsara ine pigmentation yakasiyana, yakashandisa hydrogen peroxide semuenzaniso weoxidant, uye yakaongorora vhitamini C kuti iwedzere mukana wekuuraya sero melanoma nekuwedzera kukuvadzwa kweDNA oxidation.

Vatsvakurudzi vakaedza huwandu hwevhitamini C-induced DNA kukuvara mumasero mashanu uye vakawana kuti kana ichienzaniswa neyakajairwa masero eganda, keratinocytes (HaCaT), mazinga ekupedzisira DNA kukuvadzwa aiwanzo kukwirira mumasero ese eMM, kuitira kukuvadza kuoma: SK23 masero ane pigmentation yakakura, SK28 masero ane mwero pigmentation, A37M masero asina pigmentation, A37M masero A37M. yaive nedhigirii yakaderera yekukuvara kweDNA.

Pamusoro pezvo, vaongorori vakaongorora kunzwisiswa kwemitsara mishanu yesero kukuvadzwa kunokonzerwa neoxidant (hydrogen peroxide) uye vakawana kuti kukuvadza kwekunzwa kuhydrogen peroxide kwaienderana nezviri pamusoro.

Kumwe kuongorora kwe intracellular oxidative marudzi kwakaratidza kuti MM masero airatidza zvakanyanya endogenous mazinga e intracellular oxidative marudzi kupfuura masero eHaCaT, uye kutevedzana kwemasero mashanu mitsara kwaienderana nekukuvara kweDNA, kukuvara kwekunzwa, uye cytopigmentation.

Tevere, vaongorori vakabata maseru aine kana asina vhitamini C uye vakaongorora zvingangoita mhedzisiro yevhitamini C pane oxidation-induced DNA kukuvara kuumbwa uye kuuraya masero.

Mhedzisiro yakaratidza kuti kune ese maMM maseru, nhanho yekukuvadza kweDNA kunokonzerwa nevhitamini C kurapwa kwakawedzera zvakanyanya, nepo iyo yeHaCaT masero yakanga isingakoshi, uye iyo induced endogenous DNA kukuvara kwaienderana nezviri pamusoro.

Mukuwedzera, chiyero chevhitamini C-induced nucleobase kukuvara chaive chepamusoro mumasero ane pigmented SK23 (18.5%) uye akaderera mune asina-pigmented A375P masero (14.2%).

Zvichienderana nekuti vhitamini C inogona kukwidziridza peroxide inokonzeresa kukuvara kweDNA uye kukuvara kwenucleobase mumaseru eMM, vaongorori vakaongororawo mabatiro evhitamini C paDNA akaputsika tambo mbiri ndokuona kuti kune ese maMM maseru, mwero weDNA kaviri tambo breaks inokonzerwa nevhitamini C kurapwa yakawedzera zvakanyanya, asi kwete yeHaCaT masero. Kutevedzana kwemitsara yesero mishanu kuchiri kuenderana nezviri pamusoro.

Zvakakosha, vatsvakurudzi vakaongorora kana vhitamini C yakawedzera peroxid-induced MM cell death, uye vakaona kuti vhitamini C yakasimudzira peroxid-induced kuuraya kwese MM masero, ichiita basa rekudzivirira mumasero eHaCaT, uye kutevedzana kwekuuraya kwaienderana nezviri pamusoro.

Chekupedzisira, chidzidzo ichi chakawanawo kuti vhitamini C inogona kuwedzera kushanda kweiyo iripo melanoma drug Elesclomol, ichiwedzera zvakanyanya kukuvadzwa kweDNA kwemasero egomarara akakonzerwa neElesclomol.

Vatsvagiri vakati kushandisa vhitamini C, iyo inogona kuwedzera kukuvara kweDNA mumaseru egomarara uye kukonzeresa kufa kwegomarara, inogona kunge iri nzira inoshanda yekurapa melanoma, iyo ichiri kuda zvimwe zvidzidzo zvekiriniki uye miedzo kuti ione.

Tichifunga kuti vhitamini C yakanyatso dzidza uye inozivikanwa kuva inoshivirirwa zvakanaka, vaongorori vanotenda kuti varapi vanogona kushandisa vhitamini C sekuwedzera kwekuwedzera marapirwo aripo.

Kutorwa pamwechete, iyi in vitro kudzidza inoratidza izvozvovitamini Cinogona kuwedzera oxidation-induced endo native DNA kukuvara, kukurudzira cancer cell kufa, uku ichitamba basa rekudzivirira mumasero eganda akajairwa, uye kuwedzera kushanda kwemishonga iripo yemelanoma, iyo inofanirwa kuenderera mberi nekudzidza.