Kare sekutanga kwema1930s, masayendisiti akawana kuti kuvhenekerwa nezuva kana kushandiswa kwemafuta emuorivhi, flaxseed mafuta, uye zvimwe zvikafu zveUV zvine irradiated zvinogona kurwisa osteoporosis. Kumwe kutsvagurudza kwakaitwa nemasayendisiti kwakaratidza uye akatumidza vhitamini D sechinhu chinoshanda mumuviri wemunhu kurwisa osteoporosis.

Vitamin D (VD kwenguva pfupi) ivhitamini yakanyungudika ine mafuta, inova boka rema steroid derivatives ane anti rickets mhedzisiro uye zvakafanana zvimiro. Iyo inonyanya kukosha ndeye vitamini D3 (cholecalciferol, cholecalciferol) uye vhitamini D2 (calciferol). Vhitamini D muzvokudya zvinonyanya kubva kumhuka dzakagadzirwa nemhuka dzakadai sechiropa chehove, zai yolk, bhotela, etc. Mushure mekudya, inotorwa kubva mudumbu duku muhupo hwe bile uye inotakurwa muropa nenzira ye chylomicrons. Inoshandurwa kuva 1,25-dihydroxyvitamin D3 nechiropa, itsvo, uye mitochondrial hydroxylase, iyo ine biological activity uye inogona kukurudzira kuumbwa kwe calcium binding protein (CaBP) mu intestinal mucosa, kukurudzira kunwa kwe calcium, uye kukurudzira bone calcification. 7-dehydrocholesterol, cholesterol inotorwa mumuviri wemunhu, inochengetwa pasi peganda uye inogona kushandurwa kuita cholecalciferol pasi pezuva kana ultraviolet mwaranzi. Iyo isingaperi vhitamini D inokurudzira kutorwa kwecalcium uye phosphorus.

VD inotorwa kubva kune steroids. Ikristaro chena, inonyungudika mumafuta, ine zvinhu zvakagadzikana, kupisa kwekushisa kwepamusoro, antioxidant, isingagadziriswi neasidhi uye alkali, uye inogona kuparadzwa nekuora kwemafuta. Chiropa chemhuka, mafuta echiropa chehove, uye zai yolk zvakapfuma mune zvemukati. Chinodiwa chezuva nezuva chevacheche, vana, vechidiki, vakadzi vane pamuviri, uye vanaamai vanoyamwisa i400 IU (international units). Kana ichishayikwa, vanhu vakuru vanowanzoita osteomalacia, uye vana vanowanzoita rickets. Kana ropa re calcium richiderera, panogona kuva nemaoko netsoka kuputika, kuzununguka, nezvimwewo, izvo zvine chokuitawo nekukura kwemazino. Kunyanya kudya kwevhitamini D kunogona kukonzera yakakwira calcium muropa, kurasikirwa nechido, kurutsa, manyoka, uye kunyange ectopic ossification yezvinyoro zvinyoro.