Kenza yeprostate (PC), imwe yekenza yakajairika muvarume, yakafanana nemhondi isina chinyararire, nevarwere vazhinji vachiona zvishoma nezvishoma zviratidzo zvechirwere izvo zvinogona kupedzisira zvaita kenza inouraya. Panguva iyoyo, kenza yeprostate inogona kuita isingagoneki zvekuti nzira dzese dzekurapa dziripo hadzisi kuzvipindura.

Sezvo chirevo chichienda, kurapwa kunoenderana ne "matatu mapoinzi emushonga, manomwe mapoinzi ekuchengetedza", iyi "kuchengetedza" kazhinji yenguva inoreva chikafu chekudya. Gomarara reprostate chirwere chinoramba chiripo kwenguva refu. Kana nzira dzakakodzera dzekupindira, dzakadai semararamiro anonzwisisika uye kudya, zvinogona kugamuchirwa mukutanga kwechirwere, zvinogona kunyatsononoka kufambira mberi kwekenza yeprostate uye kuvandudza kufungidzira kwevarwere.

Musi wa25 Gumiguru, 2024, timu yaMuzvinafundo Lloyd Trotman weCold Spring Harbour Laboratory yakaburitswa mupepanhau repamusoro redzidzo reScience rine musoro unoti: Dietary pro-oxidant therapy nevhitamini K precursor inotarisira PI 3-kinase VPS34 basa Retsvagiridzo bepa.

Zvidzidzo zvakawana kuti pro-oxidant supplement, menadione (vitamin K3), inogona kunonoka kufambira mberi kwegomarara reprostate. Menadione inonyungudika mumvura yevhitamini K, iyo inowanzowanikwa mumiriwo yemashizha egirinhi, uye basa rayo remuviri rinonyanya kusimudzira kugwamba kweropa uye kutora chikamu mumapfupa emasabolism.

Zvidzidzo zveMechanism zvakaratidza kuti VPS34 ndiyo yakakosha chinangwa che phosphatidylinositol 3-kinase (PI3K), menadione inogona kuvharidzira basa reVPS34, kuderedza kugadzirwa kwePI3P, uye kuwedzera oxidative kusagadzikana kunotungamirira kurufu rwemasero ekenza yeprostate. Kusiyana neizvi, maseru akajairwa anokura zvishoma nezvishoma uye saka ane simba rakakwana rekuchengetedza kukuvara uku. Pamusoro pezvo, timu yekutsvagisa yakaratidza kuti menadione inewo mushonga wekurapa mune inouraya genetic disorder inonzi X-yakabatana myotubulin myopathy (XLMTM).

Izvi zvakawanikwa zvinoratidza nzira iri nyore asi inoshanda yekupindira mugomarara uye ine mitsva mitsva yekurapa kwemamwe genetic zvirwere zvinokonzerwa ne dysregulation ye kinase chiitiko.

Dare racho rakabata RapidCaP mouse mienzaniso ne-pro-oxidant supplement, menadione sodium sulfite (MSB), musanganiswa uri mammalian precursor kune vitamin K. Vakaona kuti kuwedzera kwezuva nezuva kweMSB mumvura yekunwa kunogona kudzivisa kufambira mberi kwekenza yeprostate uye kubereka kusingaperi inhibitory effect.

Pakazara, chidzidzo, chakabudiswa muSainzi, chinoratidza kuti kuwedzera pro-oxidant supplements kune chikafu kuti uwedzere MSB kunogona kunonoka kuenderera kwechirwere cheprostate cancer. Izvi zvinodaro nekuti MSB inogona kutadzisa kuita kwePI3K kinase VPS34, kuderedza kugadzirwa kwePI3P, uye kuwedzera oxidative kusagadzikana, izvo zvinotungamira kurufu rwekenza yeprostate. Mukuwedzera, mu X-linked myotubular myopathy (XLMTM), MSB inogona kudzivisa kinase basa reVPS34, kudzorera PI3P kumazinga anogona kuvandudza kukura kwemisumbu.