Sucralose inotsiva shuga. Icho chinoshandiswa nevakawanda chinotapira chinotapira. Vanhu vanowanzokwevera kune zvinotsiva shuga nekuti zvinopa kutapira asi hazvina macalorie anowanikwa mushuga yepatafura. Sucralose inowanzoshandiswa sechinhu chinogadzirwa muzvokudya uye zvinwiwa, kazhinji inotengeswa se "isina shuga" kana "kuderedza uremu" kuderedza huwandu hwekoriori.

Chii chinonzi sucralose?

Sucralose inoshandiswa zvakanyanya isiri-inovaka muviri, zero-calorie artificial sweetener. Sucralose inogadzirwa zvine hunyanzvi kubva pashuga yepatafura (shuga yepatafura) kuburikidza nematanho akawanda anotsiva mapoka matatu ehydroxyl mumamorekuru eshuga nemaatomu matatu echlorine. Zvadaro, yakacheneswa kusvika pa98%. Aya magadzirirwo emakemikari anovimbisa kuti sucralose inotapira kanokwana ka600 kupfuura shuga yepatafura. Chigadzirwa chekupedzisira chichena, checrystalline, chinotapira chekugadzira chinotapira chinonyungudika zvakanyanya mumvura. Sucralose yakanyanya kunyungudika mumvura inoita kuti ive yakakodzera kuisirwa mumhando dzakasiyana dzezvikafu zvakabikwa: zvakabikwa, zvinwiwa, chewing gum, gelatin, uye chando chemukaka dhizeti. Vanhu vanotsvaga zvimwe zvinotapira vanowanzofarira sucralose kune zvimwe zvekugadzira zvinotapira seaspartame uye saccharin. Sezvinobva patafura yeshuga, sucralose inochengeta yakawanda yakajairika "shuga-yakafanana" kuravira, nepo ichishayikwa inovava aftertaste inowanikwa kune mamwe mashuga anotsiva. Iko kutapira kwakasimba kwe sucralose kunobvumira zvishoma zvishoma kuenda kure, zvichiita kuti ive sarudzo yakakurumbira yezvokudya zvakaderera-calori. Kutorwa kwe sucralose mudumbu remudumbu kudiki, uye nzira huru yekuburitsa haina kuchinjika sucralose muchituru. Naizvozvo, hapana catabolic (kuputsika) maitiro, achisimbisa kuti sucralose haisi sosi yesimba uye / kana macalorie. Status of Approval and regulation sucralose yakatanga kubvumidzwa kuti ishandiswe muCanada muna 1991, ichiteverwa neAustralia muna 1993 neNew Zealand muna 1996. Muna 1998, US Food and Drug Administration (FDA) yakabvumira sucralose kuti ishandiswe muzvikamu gumi nezvishanu zvechikafu nezvinwiwa, uye yakawedzera kushandiswa kwayo sechinhu chikuru-chinangwa chekushandisa seswerokera99 yechikafu yakabvumidzwa. kuwedzera muEuropean Union muna 2004. Iyo FDA inoronga sucralose sechikafu chinowedzera. Pasi peFederal Food, Drug, and Cosmetic Act, zvinotapira zvinofanirwa kuve zvakachengeteka kudya. Sarudzo yekuchengetedzwa kweFDA yakavakirwa pazvidzidzo zvemhuka zvakakura uye miedzo yekiriniki inoongorora toxicology, teratogenicity (kugona kukonzera kukanganisa kwe fetal panguva yekuzvitakura), uye carcinogenicity. Zvinoenderana neFDA kurudziro, iyo inogamuchirwa zuva nezuva yekudya (ADI) mwero we sucralose muUnited States wakaiswa pa5 mg/kg uremu hwemuviri pazuva (mg/kg/ zuva). Zvinogona kubatsira zvekushandisa sucralose kune calorie-isina uremu manejimendi

Kusiyana neshuga yepatafura, sucralose haina kugayiwa kana kuputsika mudumbu remukati uye haiite semafuta ekoriori mumiviri yedu. Saka sucralose isarudzo yakakurumbira kune vanhu vari kutsvaga kutsiva shuga yepatafura (1 teaspoon kana 4.2 magiramu eshuga yepatafura ine 16 macalorie) uye kuderedza kudyiwa kwekoriori. Nekusanganisira sucralose mukudya kwavo, vanhu vanogona kuzadzisa zvavanoda zvinotapira pasina kunetseka nezve mamwe macalories, ayo akakosha pakutonga uremu.

Inokodzera kugadzirisa chirwere cheshuga

Sucralose haina kugadzirwa nemiviri yedu kuti iwane simba uye haikonzeri kuwedzera kwemazinga ehuga yeropa (6). Kubva pane zvidzidzo zvekiriniki zve sucralose muvanhu vane chirwere cheshuga, FDA yakagumisa kuti sucralose haina kukanganisa kutonga kwenguva pfupi shuga yeropa muvanhu vane chirwere cheshuga chechipiri. Pamusoro pezvo, nhevedzano yezvidzidzo zvekiriniki zvakaratidza kuti sucralose haikanganisi kwenguva refu glucose homeostasis (sekuyerwa neHbA1c glycosylation) muvarwere vane Type 2 chirwere cheshuga. Naizvozvo, sucralose yakachengeteka inotapira sarudzo kune vane chirwere cheshuga vanochengeta yakaderera-carb chikafu. Nekudaro, sekunge chero sarudzo yekudya, vanhu vane chirwere cheshuga vanofanirwa kubvunza mushandirapamwe wavo unobatanidza kana unoshanda kune chirongwa chekudya chakasarudzika uku vachitarisa njodzi ye hypoglycemia kubva mukunwa sucralose. Zvinetso zvehutano zvinogona kuitika uye mhedzisiro Kunyange zvazvo sucralose yakaongororwa kuti ichengetedzeke nevatongi, kuchengetedzwa kwe sucralose uye zvingangoitika zvehutano zvinowanzoita nharo. Kunyanya, toxicological zvidzidzo zvinoongorora mhedzisiro yeglucose regulation, neurotoxicity, uye carcinogenicity mumhuka kazhinji inomutsa fungidziro.

Zvidzidzo zvakaratidza kuti zvinotapira zvekugadzira, zvinosanganisira sucralose, zvinokurudzira kugadzirwa kwe insulini nezvinotapira zvinogamuchirwa zvinoratidzwa pamasero e beta ari pancreas, kunyanya kana pasina glucose. Sucralose yakaratidzwawo kuti inokurudzira GLP-1 secretion. GLP-1 yakakosha kune glucose homeostasis uye kazhinji inowedzera glucose-mediated insulin secretion. Nokufamba kwenguva, kuwedzera kwe insulin muropa mushure mekusangana ne sucralose kunogona kupedzisira kutungamirira ku insulini kuramba nekuda kwekuderedzwa kwekugamuchira basa. Kukanganiswa kweglucose homeostasis (mutemo wemazinga eshuga yeropa) uye kuderedzwa kwe insulin senitivity zvinhu zvakakosha zvine chekuita nekusagadzikana kwemetabolism. Kusakwanisa kuenderera mberi kwekugadzirisa glucose kunokanganisa kurongeka kweshuga yeropa uye kunotungamirira kukukura kunotevera kwezvirwere zvemagetsi zvakadai sechirwere cheshuga chechipiri, kufutisa, uye dyslipidemia. Mukuwedzera, njodzi yekuvandudza chirwere chemwoyo inowedzera zvakanyanya. Mhedzisiro pahutano hwematumbo uye microbiome Sucralose inoonekwa se "metabolically inert" nekuti haina kunyudzwa asi inoburitswa isina kusimba muchituru. Izvi zvinoita kuti ive shoma kuve substrate yegut microbiome. Nekudaro, pane humbowo hwekuti sucralose kuratidzwa kunogona kusandura gut microbiota yedu kuburikidza nekukanganiswa kutonga kweshuga yeropa kana mhinduro inogona kudzivirirwa. Zvidzidzo zvemhuka zvakawanda zvakaratidza kuti kushandiswa kwezvisina-nutritive sweeteners (NNS) zvinogona kukonzera intestinal microbiome disorders; Yakaratidza kuwedzera kuwanda kwepathogenic bacteria uye kuderera kwakawanda kweanobatsira gut bacteria. Nekudaro, kuwedzeredza data yemhuka kuvanhu kunofanirwa kuitwa nekungwarira, sezvo kushanda kwavo kune hutano hwevanhu uye chirwere kungave kushoma. Muedzo wekiriniki wakagadzirirwa kuongorora migumisiro yenguva pfupi (14-zuva yakaoma kutarisira) kudya kwe sucralose paglucose metabolism yakaongororawo migumisiro yekudzokorora kwezuva nezuva kweNNS pagut microbiota. Chidzidzo ichi chakagumisa kuti sucralose haina kukonzera shanduko dzakakura mugut microbiota kupfuma kana kuenzana. Sezvineiwo, imwe yenguva pfupi-yakarongeka yakarongedzwa muyedzo yakaratidza kuti kudya kwekuwedzera neNNS kunogona kukanganisa kugona kweiyo microbiome yemunhu, ine sucralose ine yakanyanya kukosha. Nekudaro, zvakakosha kuziva kuti ese ari maviri ekiriniki miedzo yakaongorora mhedzisiro yenguva pfupi yeNNS yekuwedzera (kusanganisira sucralose), uye nguva yakareba yekuratidzwa inodiwa kuti unzwisise zvizere hutano hweNNS yekuwedzera pane yemunhu gut microbiome. Iyo yakareba-yakareba mhedzisiro ye sucralose uye imwe NNS pamunhu gut microbiome inzvimbo yekuenderera mberi nekutsvaga.

Neurological aspects uye appetite regulation Kunyange zvazvo sucralose ichionekwa se-calorie-isina, inomutsa zvinotapira zvinogamuchirwa, inokonzera insulin secretion mupancreas, uye inotanga metabolic cascade inotevedzera mamiriro ekudya. Mukushaikwa kweglucose, iyo inogara yakavanzika ye insulin inodzoreredza yedu metabolic chiyero uye uropi chemistry. Kudavira kwedu kunonyengerwa kuti tifunge kuti tiri kudya tsvigiri chaiyo. Muchiyedzo chisina kujairika checrossover, vatori vechikamu vechikadzi vakafutisa vakaratidza chiitiko chakawedzera munzvimbo dzehuropi dzakabatana nemhinduro yekudya cue uye kugadzirisa mubairo, zvichikonzera kuwedzera caloric kudya zvichitevera sucralose kushandiswa. Ichi chidzidzo chinopa humbowo hwakasimba hwekuti kudyiwa kwe sucralose nezvimwe zvinotapira zvekugadzira zvine chekuita nekuwedzera kuda kudya uye kushuva, kudyisa, uye kunotevera uremu uye kufutisa.