0102030405
Nei mannitol inoshanda kune urinary tract infections
2025-03-13
- Mannose (kana D-Mannose) ishuga yakapfava, asi kusiyana neglucose, mannose haisi nyore kubatwa nemuviri mushure mekudya, uye 90% yemannose inobudiswa zvakananga kuburikidza neweti mushure memaminitsi makumi matatu kusvika makumi matanhatu mushure mekutora, saka kusiyana neglucose, mannose haikanganisi shuga yeropa, asi yakanyanyisa muweti. Mannose inogona kukanganisa glucose metabolism, inhibit mafuta, kugadzirisa maruva emukati uye kutora chikamu mukugadzirisa zvirwere. Kunzwisisa kwakadzama kwemaitiro echiito chemannose mukurapa kwezvirwere zvinoenderana ndiyo kiyi yekuwedzera kuchipatara kushandiswa kwayo.Mumakore achangopfuura, pane zvidzidzo zvakawanda pamusoro pemannose. Nhasi, tichakurukura kana mannose ine chero mhedzisiro pakurapa kweurinary tract infection. Urinary tract infection chirwere chinokonzerwa nehutachiona hwehutachiona mune chero nhengo yemuviri mumugwagwa weti, kusanganisira itsvo, ureter, dundira, urethra, nezvimwewo, asi chirwere chetachiona cheti chinowanzotungamirirwa nedundira uye urethra. Nekuda kwekusiyana kwemuviri pakati pevarume nevakadzi, vakadzi vane mukana wakakura wekubatwa nezvirwere zveweti kupfuura varume. Ongororo dzinoratidza kuti vakadzi vane mukana we50 kubva muzana wekubatwa nechirwere cheweti mukati meupenyu hwavo, uye pakati pechikamu chimwe chete muzvitatu nechidimbu cheavo vanotapukirwa vachabatwa mukati megore.Kubva kuma1980s, mannose yakashandiswa nevarapi vemishonga inoshanda kurapa zvirwere zveweti. Mumakore achangopfuura, nehumbowo hwakawanda hwekutsvagisa hunoratidza kurapa nekudzivirira kwemannose, basa remannose mukurapa urinary tract infection rakakwezva zvishoma nezvishoma kutariswa kwemishonga yemazuva ese.
Mannose inoshanda sei?Kana yaburitswa kuburikidza neitsvo, dundira, uye urethra, mannose inovhara masero ematishu uye mabhakitiriya anoedza kunamatira kumaseru, zvichiita kuti utachiona hutadze kunamatira dundira uye weti duct masero, ichivharira nzira yehutachiona hwehutachiona, uye mabhakitiriya asingakwanise kunamatira kune weti turakiti tishu anoteera weti kunze kwemuviri. Zvizhinji zvezvirwere zveurinary tract zvinokonzerwa neuropathogenic Escherichia coli (UPEC). UPEC inosunga kune mannose pamusoro pedundira epithelial masero kuburikidza neFimH protein uye haisi nyore kugezwa neweti. Vakashandura mannose kuti vawane mannoside (M4284). Kubatana kwayo neFimH protein yakakwira ka100,000 pane yemannose, asi hainamati nepamusoro pedundira uye inogona kubuda neE. coli muweti.Muchidzidzo chepasi rose che2016, varwere vakatora mannose kwemazuva gumi nematatu vakawana kuderera kukuru kwezviratidzo uye nekunatsiridza kukuru kwehupenyu hwavo sekuongororwa nemibvunzo. Kuti udzivise zvirwere zvinowanzoitika zvehutachiwana, vatsvakurudzi vakaparadzanisa varwere mumapoka maviri, boka rekupindira rakaramba richitora mannose, boka rekutonga rakanga risina chinhu. Mhedzisiro yeboka remannose, chete 4.5 muzana yekudzokorora mukati memwedzi mitanhatu, zvichienzaniswa ne33,3 muzana yeboka rinodzora. Vatsvakurudzi vakagumisa kuti mannose inogona kubatsira mukurapa acute urinary tract infections uye inogona kubudirira kudzivirira kudzoka kwehutachiona hwehutachiwana.